Thionitrous Acid/Thionitrite and Perthionitrite Intermediates in the “Crosstalk” of NO and H 2 S

The chemistry of aqueous NO and H 2 S as redox regulators of cellular and physiological responses in cardiovascular, immune or neurological tissues has raised the question of the overlapping pathophysiological functions often involving similar molecular targets. The interactions of NO with H 2 S may...

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Detalles Bibliográficos
Autores principales:	Marcolongo, Juan Pablo, Slep, Leonardo Daniel, Olabe Iparraguirre, Jose Antonio
Publicado:	2017
Materias:	Hydrodisulfides Nitric oxide Nitrous oxide Nitroxyl Perthionitrite Polysulfides Thionitrite Thionitrous acid
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08988838_v70_n_p277_Marcolongo http://hdl.handle.net/20.500.12110/paper_08988838_v70_n_p277_Marcolongo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_08988838_v70_n_p277_Marcolongo
record_format	dspace
spelling	paper:paper_08988838_v70_n_p277_Marcolongo2023-06-08T15:49:29Z Thionitrous Acid/Thionitrite and Perthionitrite Intermediates in the “Crosstalk” of NO and H 2 S Marcolongo, Juan Pablo Slep, Leonardo Daniel Olabe Iparraguirre, Jose Antonio Hydrodisulfides Nitric oxide Nitrous oxide Nitroxyl Perthionitrite Polysulfides Thionitrite Thionitrous acid The chemistry of aqueous NO and H 2 S as redox regulators of cellular and physiological responses in cardiovascular, immune or neurological tissues has raised the question of the overlapping pathophysiological functions often involving similar molecular targets. The interactions of NO with H 2 S may functionally influence each other and focus has been directed to new N/S hybrid species eventually determining signaling capabilities. Besides the well-studied nitrosothiols, RSNOs, the eruption of H 2 S in the mechanistic scene has stimulated increased interest in thionitrous acid, HSNO, and thionitrite, NOS − , as well as in perthionitrite (nitrosopersulfide), S 2 NO − . We discuss the elusive chemistry of the latter molecules as intermediates in selected reactions in aqueous solution, either as free species or as bound to iron metal centers. The coordination chemistry involves mainly an updating on the “Gmelin” reaction proceeding upon mixing nitroprusside [Fe(CN) 5 (NO)] 2 − and H 2 S, with controversial and still unsolved mechanistic issues related to the onset of NO, HNO/N 2 O, polysulfides HS n − (n = 2–7), together with bound thionitrous acid/thionitrite/perthionitrite and other intermediates and products. © 2017 Elsevier Inc. Fil:Marcolongo, J.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Slep, L.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Olabe, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08988838_v70_n_p277_Marcolongo http://hdl.handle.net/20.500.12110/paper_08988838_v70_n_p277_Marcolongo
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Hydrodisulfides Nitric oxide Nitrous oxide Nitroxyl Perthionitrite Polysulfides Thionitrite Thionitrous acid
spellingShingle	Hydrodisulfides Nitric oxide Nitrous oxide Nitroxyl Perthionitrite Polysulfides Thionitrite Thionitrous acid Marcolongo, Juan Pablo Slep, Leonardo Daniel Olabe Iparraguirre, Jose Antonio Thionitrous Acid/Thionitrite and Perthionitrite Intermediates in the “Crosstalk” of NO and H 2 S
topic_facet	Hydrodisulfides Nitric oxide Nitrous oxide Nitroxyl Perthionitrite Polysulfides Thionitrite Thionitrous acid
description	The chemistry of aqueous NO and H 2 S as redox regulators of cellular and physiological responses in cardiovascular, immune or neurological tissues has raised the question of the overlapping pathophysiological functions often involving similar molecular targets. The interactions of NO with H 2 S may functionally influence each other and focus has been directed to new N/S hybrid species eventually determining signaling capabilities. Besides the well-studied nitrosothiols, RSNOs, the eruption of H 2 S in the mechanistic scene has stimulated increased interest in thionitrous acid, HSNO, and thionitrite, NOS − , as well as in perthionitrite (nitrosopersulfide), S 2 NO − . We discuss the elusive chemistry of the latter molecules as intermediates in selected reactions in aqueous solution, either as free species or as bound to iron metal centers. The coordination chemistry involves mainly an updating on the “Gmelin” reaction proceeding upon mixing nitroprusside [Fe(CN) 5 (NO)] 2 − and H 2 S, with controversial and still unsolved mechanistic issues related to the onset of NO, HNO/N 2 O, polysulfides HS n − (n = 2–7), together with bound thionitrous acid/thionitrite/perthionitrite and other intermediates and products. © 2017 Elsevier Inc.
author	Marcolongo, Juan Pablo Slep, Leonardo Daniel Olabe Iparraguirre, Jose Antonio
author_facet	Marcolongo, Juan Pablo Slep, Leonardo Daniel Olabe Iparraguirre, Jose Antonio
author_sort	Marcolongo, Juan Pablo
title	Thionitrous Acid/Thionitrite and Perthionitrite Intermediates in the “Crosstalk” of NO and H 2 S
title_short	Thionitrous Acid/Thionitrite and Perthionitrite Intermediates in the “Crosstalk” of NO and H 2 S
title_full	Thionitrous Acid/Thionitrite and Perthionitrite Intermediates in the “Crosstalk” of NO and H 2 S
title_fullStr	Thionitrous Acid/Thionitrite and Perthionitrite Intermediates in the “Crosstalk” of NO and H 2 S
title_full_unstemmed	Thionitrous Acid/Thionitrite and Perthionitrite Intermediates in the “Crosstalk” of NO and H 2 S
title_sort	thionitrous acid/thionitrite and perthionitrite intermediates in the “crosstalk” of no and h 2 s
publishDate	2017
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08988838_v70_n_p277_Marcolongo http://hdl.handle.net/20.500.12110/paper_08988838_v70_n_p277_Marcolongo
work_keys_str_mv	AT marcolongojuanpablo thionitrousacidthionitriteandperthionitriteintermediatesinthecrosstalkofnoandh2s AT slepleonardodaniel thionitrousacidthionitriteandperthionitriteintermediatesinthecrosstalkofnoandh2s AT olabeiparraguirrejoseantonio thionitrousacidthionitriteandperthionitriteintermediatesinthecrosstalkofnoandh2s
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Thionitrous Acid/Thionitrite and Perthionitrite Intermediates in the “Crosstalk” of NO and H 2 S

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