Protein synthesis subserves reconsolidation or extinction depending on reminder duration
When learned associations are recalled from long-term memory stores by presentation of an unreinforced conditioned stimulus (CS), two processes are initiated. One, termed reconsolidation, re-activates the association between the conditioned and unconditioned stimuli and transfers it from a stable pr...
Guardado en:
| Autor principal: | |
|---|---|
| Publicado: |
2003
|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08966273_v38_n6_p863_Pedreira http://hdl.handle.net/20.500.12110/paper_08966273_v38_n6_p863_Pedreira |
| Aporte de: |
| id |
paper:paper_08966273_v38_n6_p863_Pedreira |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_08966273_v38_n6_p863_Pedreira2023-06-08T15:49:12Z Protein synthesis subserves reconsolidation or extinction depending on reminder duration Pedreira, Maria Eugenia animal experiment article controlled study crab invertebrate learning memory nonhuman priority journal protein synthesis reinforcement reminder system stimulus visual system When learned associations are recalled from long-term memory stores by presentation of an unreinforced conditioned stimulus (CS), two processes are initiated. One, termed reconsolidation, re-activates the association between the conditioned and unconditioned stimuli and transfers it from a stable protein synthesis-independent form of storage to a more labile protein-dependent state. The other is an extinction process in which presentation of the CS alone degrades the association between CS and US. To address the mechanistic relationship between reconsolidation and extinction, we have used an invertebrate model of contextual memory, which involves an association between the learning context and a visual danger stimulus. Here, we show that re-exposure duration to the learning context acts as a switch guiding the memory course toward reconsolidation or extinction, each depending on protein synthesis. Manipulation of this variable allows findings of impaired extinction to be discriminated from those of disrupted reconsolidation. Fil:Pedreira, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08966273_v38_n6_p863_Pedreira http://hdl.handle.net/20.500.12110/paper_08966273_v38_n6_p863_Pedreira |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
animal experiment article controlled study crab invertebrate learning memory nonhuman priority journal protein synthesis reinforcement reminder system stimulus visual system |
| spellingShingle |
animal experiment article controlled study crab invertebrate learning memory nonhuman priority journal protein synthesis reinforcement reminder system stimulus visual system Pedreira, Maria Eugenia Protein synthesis subserves reconsolidation or extinction depending on reminder duration |
| topic_facet |
animal experiment article controlled study crab invertebrate learning memory nonhuman priority journal protein synthesis reinforcement reminder system stimulus visual system |
| description |
When learned associations are recalled from long-term memory stores by presentation of an unreinforced conditioned stimulus (CS), two processes are initiated. One, termed reconsolidation, re-activates the association between the conditioned and unconditioned stimuli and transfers it from a stable protein synthesis-independent form of storage to a more labile protein-dependent state. The other is an extinction process in which presentation of the CS alone degrades the association between CS and US. To address the mechanistic relationship between reconsolidation and extinction, we have used an invertebrate model of contextual memory, which involves an association between the learning context and a visual danger stimulus. Here, we show that re-exposure duration to the learning context acts as a switch guiding the memory course toward reconsolidation or extinction, each depending on protein synthesis. Manipulation of this variable allows findings of impaired extinction to be discriminated from those of disrupted reconsolidation. |
| author |
Pedreira, Maria Eugenia |
| author_facet |
Pedreira, Maria Eugenia |
| author_sort |
Pedreira, Maria Eugenia |
| title |
Protein synthesis subserves reconsolidation or extinction depending on reminder duration |
| title_short |
Protein synthesis subserves reconsolidation or extinction depending on reminder duration |
| title_full |
Protein synthesis subserves reconsolidation or extinction depending on reminder duration |
| title_fullStr |
Protein synthesis subserves reconsolidation or extinction depending on reminder duration |
| title_full_unstemmed |
Protein synthesis subserves reconsolidation or extinction depending on reminder duration |
| title_sort |
protein synthesis subserves reconsolidation or extinction depending on reminder duration |
| publishDate |
2003 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08966273_v38_n6_p863_Pedreira http://hdl.handle.net/20.500.12110/paper_08966273_v38_n6_p863_Pedreira |
| work_keys_str_mv |
AT pedreiramariaeugenia proteinsynthesissubservesreconsolidationorextinctiondependingonreminderduration |
| _version_ |
1768543187644710912 |