A SPECT study of Parkinsonism in Alzheimer's disease

The authors examined the presence of significant regional cerebral blood flow (rCBF) differences between Alzheimer's disease (AD) patients with and without extrapyramidal signs (EPS). Nine patients with probable AD and EPS (resting tremor or rigidity and bradykinesia) and 9 AD patients without...

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Detalles Bibliográficos
Publicado: 1995
Materias:
hexamethylpropylene amine oxime technetium tc 99m
aged
Alzheimer disease
article
bradykinesia
brain blood flow
clinical article
cognitive defect
extrapyramidal symptom
female
frontal lobe
human
left hemisphere
male
parietal lobe
parkinsonism
priority journal
rigidity
single photon emission computer tomography
temporal lobe
tremor
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08950172_v7_n3_p308_Starkstein
http://hdl.handle.net/20.500.12110/paper_08950172_v7_n3_p308_Starkstein
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_08950172_v7_n3_p308_Starkstein
record_format dspace
spelling paper:paper_08950172_v7_n3_p308_Starkstein2023-06-08T15:48:00Z A SPECT study of Parkinsonism in Alzheimer's disease hexamethylpropylene amine oxime technetium tc 99m aged Alzheimer disease article bradykinesia brain blood flow clinical article cognitive defect extrapyramidal symptom female frontal lobe human left hemisphere male parietal lobe parkinsonism priority journal rigidity single photon emission computer tomography temporal lobe tremor The authors examined the presence of significant regional cerebral blood flow (rCBF) differences between Alzheimer's disease (AD) patients with and without extrapyramidal signs (EPS). Nine patients with probable AD and EPS (resting tremor or rigidity and bradykinesia) and 9 AD patients without EPS, comparable in age, duration of illness, and global cognitive decline, were studied with [99mTc]HMPAO SPECT. Patients with AD and EPS showed significantly lower rCBF in the superior frontal, superior temporal, and parietal regions of the left hemisphere than AD patients without EPS. Rigidity and bradykinesia independently accounted for the decreased rCBF in these areas. These findings suggest that the presence of EPS in AD may result from dysfunction in specific brain regions. 1995 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08950172_v7_n3_p308_Starkstein http://hdl.handle.net/20.500.12110/paper_08950172_v7_n3_p308_Starkstein
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic hexamethylpropylene amine oxime technetium tc 99m
aged
Alzheimer disease
article
bradykinesia
brain blood flow
clinical article
cognitive defect
extrapyramidal symptom
female
frontal lobe
human
left hemisphere
male
parietal lobe
parkinsonism
priority journal
rigidity
single photon emission computer tomography
temporal lobe
tremor
spellingShingle hexamethylpropylene amine oxime technetium tc 99m
aged
Alzheimer disease
article
bradykinesia
brain blood flow
clinical article
cognitive defect
extrapyramidal symptom
female
frontal lobe
human
left hemisphere
male
parietal lobe
parkinsonism
priority journal
rigidity
single photon emission computer tomography
temporal lobe
tremor
A SPECT study of Parkinsonism in Alzheimer's disease
topic_facet hexamethylpropylene amine oxime technetium tc 99m
aged
Alzheimer disease
article
bradykinesia
brain blood flow
clinical article
cognitive defect
extrapyramidal symptom
female
frontal lobe
human
left hemisphere
male
parietal lobe
parkinsonism
priority journal
rigidity
single photon emission computer tomography
temporal lobe
tremor
description The authors examined the presence of significant regional cerebral blood flow (rCBF) differences between Alzheimer's disease (AD) patients with and without extrapyramidal signs (EPS). Nine patients with probable AD and EPS (resting tremor or rigidity and bradykinesia) and 9 AD patients without EPS, comparable in age, duration of illness, and global cognitive decline, were studied with [99mTc]HMPAO SPECT. Patients with AD and EPS showed significantly lower rCBF in the superior frontal, superior temporal, and parietal regions of the left hemisphere than AD patients without EPS. Rigidity and bradykinesia independently accounted for the decreased rCBF in these areas. These findings suggest that the presence of EPS in AD may result from dysfunction in specific brain regions.
title A SPECT study of Parkinsonism in Alzheimer's disease
title_short A SPECT study of Parkinsonism in Alzheimer's disease
title_full A SPECT study of Parkinsonism in Alzheimer's disease
title_fullStr A SPECT study of Parkinsonism in Alzheimer's disease
title_full_unstemmed A SPECT study of Parkinsonism in Alzheimer's disease
title_sort spect study of parkinsonism in alzheimer's disease
publishDate 1995
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08950172_v7_n3_p308_Starkstein
http://hdl.handle.net/20.500.12110/paper_08950172_v7_n3_p308_Starkstein
_version_ 1768542894668382208

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