Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction

Long-lasting changes in dendritic spines provide a physical correlate for memory formation and persistence. LIM kinase (LIMK) plays a critical role in orchestrating dendritic actin dynamics during memory processing, since it is the convergent downstream target of both the Rac1/PAK and RhoA/ROCK path...

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Autores principales:	De La Fuente, Veronica, Romano, Arturo Gabriel
Publicado:	2018
Materias:	BMS-5 Dorsal hippocampus Memory Rats bms 5 LIM kinase protein serine threonine kinase inhibitor unclassified drug enzyme inhibitor animal experiment Article dorsal hippocampus enzyme activity enzyme inhibition fear conditioning test male memory memory acquisition memory consolidation memory extinction memory reconsolidation memory retrieval nonhuman rat animal antagonists and inhibitors conditioning drug effect fear hippocampus pain threshold reinforcement Wistar rat Animals Conditioning (Psychology) Enzyme Inhibitors Extinction, Psychological Fear Hippocampus Lim Kinases Male Memory Consolidation Pain Threshold Rats, Wistar
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08937648_v55_n2_p958_Lunardi http://hdl.handle.net/20.500.12110/paper_08937648_v55_n2_p958_Lunardi
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_08937648_v55_n2_p958_Lunardi
record_format	dspace
spelling	paper:paper_08937648_v55_n2_p958_Lunardi2023-06-08T15:47:34Z Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction De La Fuente, Veronica Romano, Arturo Gabriel BMS-5 Dorsal hippocampus Memory Rats bms 5 LIM kinase protein serine threonine kinase inhibitor unclassified drug enzyme inhibitor LIM kinase animal experiment Article dorsal hippocampus enzyme activity enzyme inhibition fear conditioning test male memory memory acquisition memory consolidation memory extinction memory reconsolidation memory retrieval nonhuman rat animal antagonists and inhibitors conditioning drug effect fear hippocampus memory pain threshold reinforcement Wistar rat Animals Conditioning (Psychology) Enzyme Inhibitors Extinction, Psychological Fear Hippocampus Lim Kinases Male Memory Memory Consolidation Pain Threshold Rats Rats, Wistar Long-lasting changes in dendritic spines provide a physical correlate for memory formation and persistence. LIM kinase (LIMK) plays a critical role in orchestrating dendritic actin dynamics during memory processing, since it is the convergent downstream target of both the Rac1/PAK and RhoA/ROCK pathways that in turn induce cofilin phosphorylation and prevent depolymerization of actin filaments. Here, using a potent LIMK inhibitor (BMS-5), we investigated the role of LIMK activity in the dorsal hippocampus during contextual fear memory in rats. We first found that post-training administration of BMS-5 impaired memory consolidation in a dose-dependent manner. Inhibiting LIMK before training also disrupted memory acquisition. We then demonstrated that hippocampal LIMK activity seems to be critical for memory retrieval and reconsolidation, since both processes were impaired by BMS-5 treatment. Contextual fear memory extinction, however, was not sensitive to the same treatment. In conclusion, our findings demonstrate that hippocampal LIMK activity plays an important role in memory acquisition, consolidation, retrieval, and reconsolidation during contextual fear conditioning. © 2017, Springer Science+Business Media New York. Fil:de la Fuente, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08937648_v55_n2_p958_Lunardi http://hdl.handle.net/20.500.12110/paper_08937648_v55_n2_p958_Lunardi
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	BMS-5 Dorsal hippocampus Memory Rats bms 5 LIM kinase protein serine threonine kinase inhibitor unclassified drug enzyme inhibitor LIM kinase animal experiment Article dorsal hippocampus enzyme activity enzyme inhibition fear conditioning test male memory memory acquisition memory consolidation memory extinction memory reconsolidation memory retrieval nonhuman rat animal antagonists and inhibitors conditioning drug effect fear hippocampus memory pain threshold reinforcement Wistar rat Animals Conditioning (Psychology) Enzyme Inhibitors Extinction, Psychological Fear Hippocampus Lim Kinases Male Memory Memory Consolidation Pain Threshold Rats Rats, Wistar
spellingShingle	BMS-5 Dorsal hippocampus Memory Rats bms 5 LIM kinase protein serine threonine kinase inhibitor unclassified drug enzyme inhibitor LIM kinase animal experiment Article dorsal hippocampus enzyme activity enzyme inhibition fear conditioning test male memory memory acquisition memory consolidation memory extinction memory reconsolidation memory retrieval nonhuman rat animal antagonists and inhibitors conditioning drug effect fear hippocampus memory pain threshold reinforcement Wistar rat Animals Conditioning (Psychology) Enzyme Inhibitors Extinction, Psychological Fear Hippocampus Lim Kinases Male Memory Memory Consolidation Pain Threshold Rats Rats, Wistar De La Fuente, Veronica Romano, Arturo Gabriel Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction
topic_facet	BMS-5 Dorsal hippocampus Memory Rats bms 5 LIM kinase protein serine threonine kinase inhibitor unclassified drug enzyme inhibitor LIM kinase animal experiment Article dorsal hippocampus enzyme activity enzyme inhibition fear conditioning test male memory memory acquisition memory consolidation memory extinction memory reconsolidation memory retrieval nonhuman rat animal antagonists and inhibitors conditioning drug effect fear hippocampus memory pain threshold reinforcement Wistar rat Animals Conditioning (Psychology) Enzyme Inhibitors Extinction, Psychological Fear Hippocampus Lim Kinases Male Memory Memory Consolidation Pain Threshold Rats Rats, Wistar
description	Long-lasting changes in dendritic spines provide a physical correlate for memory formation and persistence. LIM kinase (LIMK) plays a critical role in orchestrating dendritic actin dynamics during memory processing, since it is the convergent downstream target of both the Rac1/PAK and RhoA/ROCK pathways that in turn induce cofilin phosphorylation and prevent depolymerization of actin filaments. Here, using a potent LIMK inhibitor (BMS-5), we investigated the role of LIMK activity in the dorsal hippocampus during contextual fear memory in rats. We first found that post-training administration of BMS-5 impaired memory consolidation in a dose-dependent manner. Inhibiting LIMK before training also disrupted memory acquisition. We then demonstrated that hippocampal LIMK activity seems to be critical for memory retrieval and reconsolidation, since both processes were impaired by BMS-5 treatment. Contextual fear memory extinction, however, was not sensitive to the same treatment. In conclusion, our findings demonstrate that hippocampal LIMK activity plays an important role in memory acquisition, consolidation, retrieval, and reconsolidation during contextual fear conditioning. © 2017, Springer Science+Business Media New York.
author	De La Fuente, Veronica Romano, Arturo Gabriel
author_facet	De La Fuente, Veronica Romano, Arturo Gabriel
author_sort	De La Fuente, Veronica
title	Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction
title_short	Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction
title_full	Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction
title_fullStr	Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction
title_full_unstemmed	Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction
title_sort	effects of hippocampal limk inhibition on memory acquisition, consolidation, retrieval, reconsolidation, and extinction
publishDate	2018
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08937648_v55_n2_p958_Lunardi http://hdl.handle.net/20.500.12110/paper_08937648_v55_n2_p958_Lunardi
work_keys_str_mv	AT delafuenteveronica effectsofhippocampallimkinhibitiononmemoryacquisitionconsolidationretrievalreconsolidationandextinction AT romanoarturogabriel effectsofhippocampallimkinhibitiononmemoryacquisitionconsolidationretrievalreconsolidationandextinction
_version_	1768542650149896192

Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction

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