Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration
It is well known that, under certain boundary conditions, the retrieval of a stable consolidated memory results into a labile one. During this unstable phase, memory can be vulnerable to interference by a number of pharmacological agents, including benzodiazepines. One of the goals of this study was...
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2010
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paper:paper_0893133X_v35_n5_p1097_Bustos2023-06-08T15:47:29Z Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration D-cyloserine Fear memory Midazolam Reactivation-reconsolidation Stress cycloserine midazolam n methyl dextro aspartic acid sodium chloride animal experiment animal model article clinical research controlled study drug effect drug sensitivity fear information retrieval learning male memory memory disorder mental instability nonhuman priority journal rat stress training Animals Conditioning, Classical Cycloserine Dose-Response Relationship, Drug Fear GABA Modulators Male Memory Midazolam Neurotransmitter Agents Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate Stress, Psychological Time Factors It is well known that, under certain boundary conditions, the retrieval of a stable consolidated memory results into a labile one. During this unstable phase, memory can be vulnerable to interference by a number of pharmacological agents, including benzodiazepines. One of the goals of this study was to evaluate the vulnerability to midazolam (MDZ) after reactivation of recent and remote contextual fear memories in animals that experienced a stressful situation before learning. Animals were subjected to a restraint session and trained in a contextual fear paradigm the following day; consolidated memories were reactivated at different times after learning and different MDZ doses (1.5, 3.0 mg/kg) were administered to rats after reactivation. Our results show that MDZ did not affect memory reconsolidation in older-than-one-day memories of stressed animals, even after the administration of a higher MDZ dose and a longer reactivation session (5 min). In contrast, MDZ was effective in blocking reconsolidation at all memory ages in unstressed animals. In addition, the current research investigated whether activating NMDA sites before reactivation promotes the destabilization of resistant memories such as those of stressed animals. We tested the influence of pre-reactivation D-cycloserine (DCS), a partial NMDA agonist, on MDZ's effect on fear memory reconsolidation in stressed animals. Our findings indicate that DCS before reactivation promotes retrieval-induced lability in resistant memory traces, as MDZ-induced memory impairment in stressed rats became evident with pre-reactivation DCS but not after pre-reactivation sterile isotonic saline. © 2010 Nature Publishing Group All rights reserved. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0893133X_v35_n5_p1097_Bustos http://hdl.handle.net/20.500.12110/paper_0893133X_v35_n5_p1097_Bustos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
D-cyloserine Fear memory Midazolam Reactivation-reconsolidation Stress cycloserine midazolam n methyl dextro aspartic acid sodium chloride animal experiment animal model article clinical research controlled study drug effect drug sensitivity fear information retrieval learning male memory memory disorder mental instability nonhuman priority journal rat stress training Animals Conditioning, Classical Cycloserine Dose-Response Relationship, Drug Fear GABA Modulators Male Memory Midazolam Neurotransmitter Agents Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate Stress, Psychological Time Factors |
| spellingShingle |
D-cyloserine Fear memory Midazolam Reactivation-reconsolidation Stress cycloserine midazolam n methyl dextro aspartic acid sodium chloride animal experiment animal model article clinical research controlled study drug effect drug sensitivity fear information retrieval learning male memory memory disorder mental instability nonhuman priority journal rat stress training Animals Conditioning, Classical Cycloserine Dose-Response Relationship, Drug Fear GABA Modulators Male Memory Midazolam Neurotransmitter Agents Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate Stress, Psychological Time Factors Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration |
| topic_facet |
D-cyloserine Fear memory Midazolam Reactivation-reconsolidation Stress cycloserine midazolam n methyl dextro aspartic acid sodium chloride animal experiment animal model article clinical research controlled study drug effect drug sensitivity fear information retrieval learning male memory memory disorder mental instability nonhuman priority journal rat stress training Animals Conditioning, Classical Cycloserine Dose-Response Relationship, Drug Fear GABA Modulators Male Memory Midazolam Neurotransmitter Agents Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate Stress, Psychological Time Factors |
| description |
It is well known that, under certain boundary conditions, the retrieval of a stable consolidated memory results into a labile one. During this unstable phase, memory can be vulnerable to interference by a number of pharmacological agents, including benzodiazepines. One of the goals of this study was to evaluate the vulnerability to midazolam (MDZ) after reactivation of recent and remote contextual fear memories in animals that experienced a stressful situation before learning. Animals were subjected to a restraint session and trained in a contextual fear paradigm the following day; consolidated memories were reactivated at different times after learning and different MDZ doses (1.5, 3.0 mg/kg) were administered to rats after reactivation. Our results show that MDZ did not affect memory reconsolidation in older-than-one-day memories of stressed animals, even after the administration of a higher MDZ dose and a longer reactivation session (5 min). In contrast, MDZ was effective in blocking reconsolidation at all memory ages in unstressed animals. In addition, the current research investigated whether activating NMDA sites before reactivation promotes the destabilization of resistant memories such as those of stressed animals. We tested the influence of pre-reactivation D-cycloserine (DCS), a partial NMDA agonist, on MDZ's effect on fear memory reconsolidation in stressed animals. Our findings indicate that DCS before reactivation promotes retrieval-induced lability in resistant memory traces, as MDZ-induced memory impairment in stressed rats became evident with pre-reactivation DCS but not after pre-reactivation sterile isotonic saline. © 2010 Nature Publishing Group All rights reserved. |
| title |
Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration |
| title_short |
Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration |
| title_full |
Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration |
| title_fullStr |
Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration |
| title_full_unstemmed |
Previous stress Attenuates the Susceptibility to Midazolam's Disruptive Effect on Fear Memory Reconsolidation: Influence of Pre-Reactivation D-Cycloserine Administration |
| title_sort |
previous stress attenuates the susceptibility to midazolam's disruptive effect on fear memory reconsolidation: influence of pre-reactivation d-cycloserine administration |
| publishDate |
2010 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0893133X_v35_n5_p1097_Bustos http://hdl.handle.net/20.500.12110/paper_0893133X_v35_n5_p1097_Bustos |
| _version_ |
1768546306607808512 |