Control of dendritic cell maturation and function by triiodothyronine

Accumulating evidence indicates a functional crosstalk between immune and endocrine mechanisms in the modulation of innate and adaptive immunity. However, the impact of thyroid hormones (THs) in the initiation of adaptive immune responses has not yet been examined. Here we investigated the presence...

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Autor principal:	Ilarregui, Juan Martín
Publicado:	2008
Materias:	Adaptive immunity Antigen presentation Thyroid hormones B7 antigen CD40 antigen CD86 antigen cell marker gamma interferon immunoglobulin enhancer binding protein interleukin 12 liothyronine lipopolysaccharide major histocompatibility antigen class 2 messenger RNA protein thyroid hormone receptor adaptive immunity animal cell animal experiment antigen presenting cell article autoimmune disease bone marrow cell culture cell function cell maturation cytokine release cytoplasm dendritic cell endocrine system female immune system immunopathology interferon production lymphocyte proliferation mouse neoplasm nonhuman priority journal T lymphocyte activation thyroid gland Animals Bone Marrow Cells Cell Differentiation Cercopithecus aethiops COS Cells Cytosol Dendritic Cells Female Flow Cytometry Interleukin-12 Mice Receptors, Thyroid Hormone T-Lymphocytes Transfection Triiodothyronine
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v22_n4_p1032_Mascanfroni http://hdl.handle.net/20.500.12110/paper_08926638_v22_n4_p1032_Mascanfroni
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_08926638_v22_n4_p1032_Mascanfroni
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spelling	paper:paper_08926638_v22_n4_p1032_Mascanfroni2023-06-08T15:47:22Z Control of dendritic cell maturation and function by triiodothyronine Ilarregui, Juan Martín Adaptive immunity Antigen presentation Thyroid hormones B7 antigen CD40 antigen CD86 antigen cell marker gamma interferon immunoglobulin enhancer binding protein interleukin 12 liothyronine lipopolysaccharide major histocompatibility antigen class 2 messenger RNA protein thyroid hormone receptor adaptive immunity animal cell animal experiment antigen presenting cell article autoimmune disease bone marrow cell culture cell function cell maturation cytokine release cytoplasm dendritic cell endocrine system female immune system immunopathology interferon production lymphocyte proliferation mouse neoplasm nonhuman priority journal T lymphocyte activation thyroid gland Animals Bone Marrow Cells Cell Differentiation Cercopithecus aethiops COS Cells Cytosol Dendritic Cells Female Flow Cytometry Interleukin-12 Mice Receptors, Thyroid Hormone T-Lymphocytes Transfection Triiodothyronine Accumulating evidence indicates a functional crosstalk between immune and endocrine mechanisms in the modulation of innate and adaptive immunity. However, the impact of thyroid hormones (THs) in the initiation of adaptive immune responses has not yet been examined. Here we investigated the presence of thyroid hormone receptors (TRs) and the impact of THs in the physiology of mouse dendritic cells (DCs), specialized antigen-presenting cells with the unique capacity to fully activate naive T cells and orchestrate adaptive immunity. Both immature and lipopolysaccharide-matured bone marrow-derived DCs expressed TRs at mRNA and protein levels, showing a preferential cytoplasmic localization. Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatability complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-γ production in allogeneic T cell cultures. Analysis of the mechanisms involved in these effects revealed the ability of T3 to influence the cytoplasmicnuclear shuttling of nuclear factor-κB on primed DCs. Our study provides the first evidence for the presence of TRs on bone marrow-derived DCs and the ability of THs to regulate DC maturation and function. These results have profound implications in immunopathology, including cancer and autoimmune manifestations of the thyroid gland at the crossroads of the immune and endocrine systems. © FASEB. Fil:Ilarregui, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v22_n4_p1032_Mascanfroni http://hdl.handle.net/20.500.12110/paper_08926638_v22_n4_p1032_Mascanfroni
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Adaptive immunity Antigen presentation Thyroid hormones B7 antigen CD40 antigen CD86 antigen cell marker gamma interferon immunoglobulin enhancer binding protein interleukin 12 liothyronine lipopolysaccharide major histocompatibility antigen class 2 messenger RNA protein thyroid hormone receptor adaptive immunity animal cell animal experiment antigen presenting cell article autoimmune disease bone marrow cell culture cell function cell maturation cytokine release cytoplasm dendritic cell endocrine system female immune system immunopathology interferon production lymphocyte proliferation mouse neoplasm nonhuman priority journal T lymphocyte activation thyroid gland Animals Bone Marrow Cells Cell Differentiation Cercopithecus aethiops COS Cells Cytosol Dendritic Cells Female Flow Cytometry Interleukin-12 Mice Receptors, Thyroid Hormone T-Lymphocytes Transfection Triiodothyronine
spellingShingle	Adaptive immunity Antigen presentation Thyroid hormones B7 antigen CD40 antigen CD86 antigen cell marker gamma interferon immunoglobulin enhancer binding protein interleukin 12 liothyronine lipopolysaccharide major histocompatibility antigen class 2 messenger RNA protein thyroid hormone receptor adaptive immunity animal cell animal experiment antigen presenting cell article autoimmune disease bone marrow cell culture cell function cell maturation cytokine release cytoplasm dendritic cell endocrine system female immune system immunopathology interferon production lymphocyte proliferation mouse neoplasm nonhuman priority journal T lymphocyte activation thyroid gland Animals Bone Marrow Cells Cell Differentiation Cercopithecus aethiops COS Cells Cytosol Dendritic Cells Female Flow Cytometry Interleukin-12 Mice Receptors, Thyroid Hormone T-Lymphocytes Transfection Triiodothyronine Ilarregui, Juan Martín Control of dendritic cell maturation and function by triiodothyronine
topic_facet	Adaptive immunity Antigen presentation Thyroid hormones B7 antigen CD40 antigen CD86 antigen cell marker gamma interferon immunoglobulin enhancer binding protein interleukin 12 liothyronine lipopolysaccharide major histocompatibility antigen class 2 messenger RNA protein thyroid hormone receptor adaptive immunity animal cell animal experiment antigen presenting cell article autoimmune disease bone marrow cell culture cell function cell maturation cytokine release cytoplasm dendritic cell endocrine system female immune system immunopathology interferon production lymphocyte proliferation mouse neoplasm nonhuman priority journal T lymphocyte activation thyroid gland Animals Bone Marrow Cells Cell Differentiation Cercopithecus aethiops COS Cells Cytosol Dendritic Cells Female Flow Cytometry Interleukin-12 Mice Receptors, Thyroid Hormone T-Lymphocytes Transfection Triiodothyronine
description	Accumulating evidence indicates a functional crosstalk between immune and endocrine mechanisms in the modulation of innate and adaptive immunity. However, the impact of thyroid hormones (THs) in the initiation of adaptive immune responses has not yet been examined. Here we investigated the presence of thyroid hormone receptors (TRs) and the impact of THs in the physiology of mouse dendritic cells (DCs), specialized antigen-presenting cells with the unique capacity to fully activate naive T cells and orchestrate adaptive immunity. Both immature and lipopolysaccharide-matured bone marrow-derived DCs expressed TRs at mRNA and protein levels, showing a preferential cytoplasmic localization. Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatability complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation and IFN-γ production in allogeneic T cell cultures. Analysis of the mechanisms involved in these effects revealed the ability of T3 to influence the cytoplasmicnuclear shuttling of nuclear factor-κB on primed DCs. Our study provides the first evidence for the presence of TRs on bone marrow-derived DCs and the ability of THs to regulate DC maturation and function. These results have profound implications in immunopathology, including cancer and autoimmune manifestations of the thyroid gland at the crossroads of the immune and endocrine systems. © FASEB.
author	Ilarregui, Juan Martín
author_facet	Ilarregui, Juan Martín
author_sort	Ilarregui, Juan Martín
title	Control of dendritic cell maturation and function by triiodothyronine
title_short	Control of dendritic cell maturation and function by triiodothyronine
title_full	Control of dendritic cell maturation and function by triiodothyronine
title_fullStr	Control of dendritic cell maturation and function by triiodothyronine
title_full_unstemmed	Control of dendritic cell maturation and function by triiodothyronine
title_sort	control of dendritic cell maturation and function by triiodothyronine
publishDate	2008
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08926638_v22_n4_p1032_Mascanfroni http://hdl.handle.net/20.500.12110/paper_08926638_v22_n4_p1032_Mascanfroni
work_keys_str_mv	AT ilarreguijuanmartin controlofdendriticcellmaturationandfunctionbytriiodothyronine
_version_	1768543473452974080

Control of dendritic cell maturation and function by triiodothyronine

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