Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug

Up to 35% of pregnant women take psychotropic drugs at least once during gestation [Austin and Mitchell, 1998]. From concurrent animal and human evidence, it has been proposed that exposure to several psychoactive medications in utero or during lactation increases the risk for permanent brain disord...

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Publicado:	2004
Materias:	Behavioral teratogen Haloperidol Therapeutic agent haloperidol animal experiment animal model animal tissue article behavior disorder behavior teratology circling behavior controlled study female lactation nonhuman perinatal drug exposure prenatal drug exposure priority journal progeny Analysis of Variance Animals Animals, Newborn Behavior, Animal Brain Dopamine Antagonists Female Male Pregnancy Prenatal Exposure Delayed Effects Radioligand Assay Random Allocation Rats Rats, Sprague-Dawley Spiperone Stereotyped Behavior Stereotypic Movement Disorder Tritium Animalia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08920362_v26_n4_p561_Wolansky http://hdl.handle.net/20.500.12110/paper_08920362_v26_n4_p561_Wolansky
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_08920362_v26_n4_p561_Wolansky
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spelling	paper:paper_08920362_v26_n4_p561_Wolansky2023-06-08T15:47:16Z Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug Behavioral teratogen Haloperidol Therapeutic agent haloperidol animal experiment animal model animal tissue article behavior disorder behavior teratology circling behavior controlled study female lactation nonhuman perinatal drug exposure prenatal drug exposure priority journal progeny Analysis of Variance Animals Animals, Newborn Behavior, Animal Brain Dopamine Antagonists Female Haloperidol Male Pregnancy Prenatal Exposure Delayed Effects Radioligand Assay Random Allocation Rats Rats, Sprague-Dawley Spiperone Stereotyped Behavior Stereotypic Movement Disorder Tritium Animalia Up to 35% of pregnant women take psychotropic drugs at least once during gestation [Austin and Mitchell, 1998]. From concurrent animal and human evidence, it has been proposed that exposure to several psychoactive medications in utero or during lactation increases the risk for permanent brain disorders. Present preventive or therapy practices applied on humans for this type of long-lasting behavioral alterations are mainly based on empirical results. Here, we test an experimental approach designed to counteract a circling performance deficit that appears in Sprague-Dawley rats at puberty on exposure to the dopaminergic blocker haloperidol (HAL) during gestation [J.L. Brusés, J.M. Azcurra, The circling training: A behavioral paradigm for functional teratology testing, in: P.M. Conn (Ed.), Paradigms for the study of behavior, Acad. Press, New York, 1993, pp. 166-179. Method Neurosci. 14]. Gestational exposure to HAL (GD 5-18, 2.5 mg/kg/day ip) induced the expected circling activity decrease in the offspring at the fifth week of life. When prenatal exposure to HAL was continued through lactation (PD5-21, 1.5 mg/kg/day ip), rats otherwise showed a control-like circling performance. No difference was yet found between lactation-only, HAL-exposed pups and saline (SAL)-treated controls (n=8 each group). We further performed saturating (3H)-spiroperidol (SPI) binding assays on striatal P2 membrane fractions 2 months later. The dopamine-type D2-specific binding results suggested that above circling behavior findings could be partially explained by enduring HAL-induced neurochemical changes. The role of critical periods of sensitivity as transient windows for opportunistic therapies for behavioral teratology is discussed. © 2004 Elsevier Inc. All rights reserved. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08920362_v26_n4_p561_Wolansky http://hdl.handle.net/20.500.12110/paper_08920362_v26_n4_p561_Wolansky
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Behavioral teratogen Haloperidol Therapeutic agent haloperidol animal experiment animal model animal tissue article behavior disorder behavior teratology circling behavior controlled study female lactation nonhuman perinatal drug exposure prenatal drug exposure priority journal progeny Analysis of Variance Animals Animals, Newborn Behavior, Animal Brain Dopamine Antagonists Female Haloperidol Male Pregnancy Prenatal Exposure Delayed Effects Radioligand Assay Random Allocation Rats Rats, Sprague-Dawley Spiperone Stereotyped Behavior Stereotypic Movement Disorder Tritium Animalia
spellingShingle	Behavioral teratogen Haloperidol Therapeutic agent haloperidol animal experiment animal model animal tissue article behavior disorder behavior teratology circling behavior controlled study female lactation nonhuman perinatal drug exposure prenatal drug exposure priority journal progeny Analysis of Variance Animals Animals, Newborn Behavior, Animal Brain Dopamine Antagonists Female Haloperidol Male Pregnancy Prenatal Exposure Delayed Effects Radioligand Assay Random Allocation Rats Rats, Sprague-Dawley Spiperone Stereotyped Behavior Stereotypic Movement Disorder Tritium Animalia Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug
topic_facet	Behavioral teratogen Haloperidol Therapeutic agent haloperidol animal experiment animal model animal tissue article behavior disorder behavior teratology circling behavior controlled study female lactation nonhuman perinatal drug exposure prenatal drug exposure priority journal progeny Analysis of Variance Animals Animals, Newborn Behavior, Animal Brain Dopamine Antagonists Female Haloperidol Male Pregnancy Prenatal Exposure Delayed Effects Radioligand Assay Random Allocation Rats Rats, Sprague-Dawley Spiperone Stereotyped Behavior Stereotypic Movement Disorder Tritium Animalia
description	Up to 35% of pregnant women take psychotropic drugs at least once during gestation [Austin and Mitchell, 1998]. From concurrent animal and human evidence, it has been proposed that exposure to several psychoactive medications in utero or during lactation increases the risk for permanent brain disorders. Present preventive or therapy practices applied on humans for this type of long-lasting behavioral alterations are mainly based on empirical results. Here, we test an experimental approach designed to counteract a circling performance deficit that appears in Sprague-Dawley rats at puberty on exposure to the dopaminergic blocker haloperidol (HAL) during gestation [J.L. Brusés, J.M. Azcurra, The circling training: A behavioral paradigm for functional teratology testing, in: P.M. Conn (Ed.), Paradigms for the study of behavior, Acad. Press, New York, 1993, pp. 166-179. Method Neurosci. 14]. Gestational exposure to HAL (GD 5-18, 2.5 mg/kg/day ip) induced the expected circling activity decrease in the offspring at the fifth week of life. When prenatal exposure to HAL was continued through lactation (PD5-21, 1.5 mg/kg/day ip), rats otherwise showed a control-like circling performance. No difference was yet found between lactation-only, HAL-exposed pups and saline (SAL)-treated controls (n=8 each group). We further performed saturating (3H)-spiroperidol (SPI) binding assays on striatal P2 membrane fractions 2 months later. The dopamine-type D2-specific binding results suggested that above circling behavior findings could be partially explained by enduring HAL-induced neurochemical changes. The role of critical periods of sensitivity as transient windows for opportunistic therapies for behavioral teratology is discussed. © 2004 Elsevier Inc. All rights reserved.
title	Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug
title_short	Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug
title_full	Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug
title_fullStr	Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug
title_full_unstemmed	Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug
title_sort	postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug
publishDate	2004
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08920362_v26_n4_p561_Wolansky http://hdl.handle.net/20.500.12110/paper_08920362_v26_n4_p561_Wolansky
_version_	1768544646307250176

Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug

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