Cytochrome P450 expression in mouse brain: Specific isoenzymes involved in Phase i metabolizing system of porphyrinogenic agents in both microsomes and mitochondria

Brain cytochrome P450 (CYP) metabolizes a variety of drugs to produce their pharmacological effects within the brain. We have previously observed that porphyrinogenic agents altered CYP levels in brain. The aim of this work was to further study the involvement of mice brain mitochondrial and microso...

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Detalles Bibliográficos
Autores principales:	Lavandera, Jimena Verónica, Batlle, Alcira María del Carmen, Buzaleh, Ana María
Publicado:	2015
Materias:	Brain Cytochrome P450 Porphyrinogenic agents Volatile anaesthetics Anesthetics Enzymes Ethanol Mammals Cytochrome p450 Microsomal proteins Mitochondrial activity NADPH-cytochrome P450 reductase Neurological disorders Pharmacological effects Western blots Whole brains Mitochondria alcohol allylisopropylacetamide barbital cytochrome P450 2B1 cytochrome P450 2E1 cytochrome P450 3A4 drug metabolizing enzyme enflurane griseofulvin isoenzyme isoflurane porphyrinogen reduced nicotinamide adenine dinucleotide ferrihemoprotein reductase cytochrome P450 cytochrome P450 3A adult animal experiment Article brain brain microsome brain mitochondrion cell fractionation controlled study immunoblotting male mouse nonhuman protein expression Western blotting animal drug effects enzymology metabolism microsome mitochondrion Animalia Mus Animals Cytochrome P-450 CYP2B1 Cytochrome P-450 CYP2E1 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System Isoenzymes Male Mice Microsomes
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08298211_v93_n1_p102_Lavandera http://hdl.handle.net/20.500.12110/paper_08298211_v93_n1_p102_Lavandera
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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