Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs
Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, and their later behavioral "despair," measured by Porsolt's swim test, was examined. At the age of two months, the...
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1989
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07418329_v6_n2_p93_FernandezPardal http://hdl.handle.net/20.500.12110/paper_07418329_v6_n2_p93_FernandezPardal |
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paper:paper_07418329_v6_n2_p93_FernandezPardal |
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paper:paper_07418329_v6_n2_p93_FernandezPardal2023-06-08T15:44:41Z Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs Alcohol Behavioral "despair" Desipramine Imipramine Neonatal Nomifensine alcohol desipramine imipramine nomifensine animal experiment behavior intraperitoneal drug administration male newborn nonhuman psychological aspect rat Animal Animals, Newborn Antidepressive Agents Depression Desipramine Ethanol Imipramine Male Motor Activity Nomifensine Rats Rats, Inbred Strains Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, and their later behavioral "despair," measured by Porsolt's swim test, was examined. At the age of two months, the desipramine-treated rats showed lengthened immobility in the swim test, and thus probably increased behavioral "despair." They also responded to 1 g/kg alcohol by shortening the immobility to the level of control rats. Neonatal treatment with either imipramine or nomifensine did not affect the swim test behavior. The results suggest that a low, stimulatory dose of alcohol was able to reverse the lengthened immobility in the swim test of rats treated with desipramine during the early postnatal period. © 1989. 1989 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07418329_v6_n2_p93_FernandezPardal http://hdl.handle.net/20.500.12110/paper_07418329_v6_n2_p93_FernandezPardal |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alcohol Behavioral "despair" Desipramine Imipramine Neonatal Nomifensine alcohol desipramine imipramine nomifensine animal experiment behavior intraperitoneal drug administration male newborn nonhuman psychological aspect rat Animal Animals, Newborn Antidepressive Agents Depression Desipramine Ethanol Imipramine Male Motor Activity Nomifensine Rats Rats, Inbred Strains |
| spellingShingle |
Alcohol Behavioral "despair" Desipramine Imipramine Neonatal Nomifensine alcohol desipramine imipramine nomifensine animal experiment behavior intraperitoneal drug administration male newborn nonhuman psychological aspect rat Animal Animals, Newborn Antidepressive Agents Depression Desipramine Ethanol Imipramine Male Motor Activity Nomifensine Rats Rats, Inbred Strains Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| topic_facet |
Alcohol Behavioral "despair" Desipramine Imipramine Neonatal Nomifensine alcohol desipramine imipramine nomifensine animal experiment behavior intraperitoneal drug administration male newborn nonhuman psychological aspect rat Animal Animals, Newborn Antidepressive Agents Depression Desipramine Ethanol Imipramine Male Motor Activity Nomifensine Rats Rats, Inbred Strains |
| description |
Rat pups were treated with monoamine uptake inhibiting antidepressant drugs, desipramine, imipramine or nomifensine (5 mg/kg) during the second and third postnatal weeks, and their later behavioral "despair," measured by Porsolt's swim test, was examined. At the age of two months, the desipramine-treated rats showed lengthened immobility in the swim test, and thus probably increased behavioral "despair." They also responded to 1 g/kg alcohol by shortening the immobility to the level of control rats. Neonatal treatment with either imipramine or nomifensine did not affect the swim test behavior. The results suggest that a low, stimulatory dose of alcohol was able to reverse the lengthened immobility in the swim test of rats treated with desipramine during the early postnatal period. © 1989. |
| title |
Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| title_short |
Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| title_full |
Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| title_fullStr |
Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| title_full_unstemmed |
Effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| title_sort |
effect of low alcohol dose on behavioral "despair" in rats neonatally treated with antidepressant drugs |
| publishDate |
1989 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07418329_v6_n2_p93_FernandezPardal http://hdl.handle.net/20.500.12110/paper_07418329_v6_n2_p93_FernandezPardal |
| _version_ |
1768543427246424064 |