S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication

The effect of disulfiram and S-adenosyl-L-methionine (SAM) administration to acute ethanol intoxicated mice on the hepatic glutathione (GSH) concentration and aminolevulinic and dehydratase (ALA-D) activity was investigated. It was found that both GSH levels and ALA-D activity were decreased, and ev...

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Autores principales:	Paredes, Sergio Raúl, Fukuda, Haydeé, Rossetti, María Victoria, Batlle, Alcira María del Carmen
Publicado:	1987
Materias:	Acetaldehyde Alcohol Glutathione S-Adenosyl-L-methionine δ-Aminolevulinic acid dehydratase alcohol glutathione porphobilinogen synthase s adenosylmethionine animal experiment drug interaction drug toxicity intoxication intraperitoneal drug administration liver liver toxicity mouse nonhuman Alcoholic Intoxication Animals Disease Models, Animal Disulfiram Erythrocytes Liver Male Mice Porphobilinogen Synthase S-Adenosylmethionine Animalia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07418329_v4_n2_p81_Paredes http://hdl.handle.net/20.500.12110/paper_07418329_v4_n2_p81_Paredes
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_07418329_v4_n2_p81_Paredes
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spelling	paper:paper_07418329_v4_n2_p81_Paredes2023-06-08T15:44:40Z S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication Paredes, Sergio Raúl Fukuda, Haydeé Rossetti, María Victoria Batlle, Alcira María del Carmen Acetaldehyde Alcohol Glutathione S-Adenosyl-L-methionine δ-Aminolevulinic acid dehydratase alcohol glutathione porphobilinogen synthase s adenosylmethionine animal experiment drug interaction drug toxicity intoxication intraperitoneal drug administration liver liver toxicity mouse nonhuman Acetaldehyde Alcoholic Intoxication Animals Disease Models, Animal Disulfiram Erythrocytes Glutathione Liver Male Mice Porphobilinogen Synthase S-Adenosylmethionine Animalia The effect of disulfiram and S-adenosyl-L-methionine (SAM) administration to acute ethanol intoxicated mice on the hepatic glutathione (GSH) concentration and aminolevulinic and dehydratase (ALA-D) activity was investigated. It was found that both GSH levels and ALA-D activity were decreased, and evidence suggested that the toxic action of ethanol was due to its conversion into acetaldehyde. Administration of SAM reverses the effects of acute alcohol abuse by increasing liver GSH availability. In vitro, hepatic ALA-D activity was not modified by ethanol; instead it was non-competitively inhibited by acetaldehyde. This inhibition was efficiently reversed by GSH and cysteine (CySH). Therefore, a mechanism for the action of ethanol on ALA-D, based on the inhibitory effect of acetaldehyde, is proposed. © 1987. Fil:Paredes, S.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fukuda, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rossetti, M.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1987 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07418329_v4_n2_p81_Paredes http://hdl.handle.net/20.500.12110/paper_07418329_v4_n2_p81_Paredes
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Acetaldehyde Alcohol Glutathione S-Adenosyl-L-methionine δ-Aminolevulinic acid dehydratase alcohol glutathione porphobilinogen synthase s adenosylmethionine animal experiment drug interaction drug toxicity intoxication intraperitoneal drug administration liver liver toxicity mouse nonhuman Acetaldehyde Alcoholic Intoxication Animals Disease Models, Animal Disulfiram Erythrocytes Glutathione Liver Male Mice Porphobilinogen Synthase S-Adenosylmethionine Animalia
spellingShingle	Acetaldehyde Alcohol Glutathione S-Adenosyl-L-methionine δ-Aminolevulinic acid dehydratase alcohol glutathione porphobilinogen synthase s adenosylmethionine animal experiment drug interaction drug toxicity intoxication intraperitoneal drug administration liver liver toxicity mouse nonhuman Acetaldehyde Alcoholic Intoxication Animals Disease Models, Animal Disulfiram Erythrocytes Glutathione Liver Male Mice Porphobilinogen Synthase S-Adenosylmethionine Animalia Paredes, Sergio Raúl Fukuda, Haydeé Rossetti, María Victoria Batlle, Alcira María del Carmen S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication
topic_facet	Acetaldehyde Alcohol Glutathione S-Adenosyl-L-methionine δ-Aminolevulinic acid dehydratase alcohol glutathione porphobilinogen synthase s adenosylmethionine animal experiment drug interaction drug toxicity intoxication intraperitoneal drug administration liver liver toxicity mouse nonhuman Acetaldehyde Alcoholic Intoxication Animals Disease Models, Animal Disulfiram Erythrocytes Glutathione Liver Male Mice Porphobilinogen Synthase S-Adenosylmethionine Animalia
description	The effect of disulfiram and S-adenosyl-L-methionine (SAM) administration to acute ethanol intoxicated mice on the hepatic glutathione (GSH) concentration and aminolevulinic and dehydratase (ALA-D) activity was investigated. It was found that both GSH levels and ALA-D activity were decreased, and evidence suggested that the toxic action of ethanol was due to its conversion into acetaldehyde. Administration of SAM reverses the effects of acute alcohol abuse by increasing liver GSH availability. In vitro, hepatic ALA-D activity was not modified by ethanol; instead it was non-competitively inhibited by acetaldehyde. This inhibition was efficiently reversed by GSH and cysteine (CySH). Therefore, a mechanism for the action of ethanol on ALA-D, based on the inhibitory effect of acetaldehyde, is proposed. © 1987.
author	Paredes, Sergio Raúl Fukuda, Haydeé Rossetti, María Victoria Batlle, Alcira María del Carmen
author_facet	Paredes, Sergio Raúl Fukuda, Haydeé Rossetti, María Victoria Batlle, Alcira María del Carmen
author_sort	Paredes, Sergio Raúl
title	S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication
title_short	S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication
title_full	S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication
title_fullStr	S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication
title_full_unstemmed	S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication
title_sort	s-adenosyl-l-methionine: its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication
publishDate	1987
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07418329_v4_n2_p81_Paredes http://hdl.handle.net/20.500.12110/paper_07418329_v4_n2_p81_Paredes
work_keys_str_mv	AT paredessergioraul sadenosyllmethionineitseffectonaminolevulinatedehydrataseandglutathioneinacuteethanolintoxication AT fukudahaydee sadenosyllmethionineitseffectonaminolevulinatedehydrataseandglutathioneinacuteethanolintoxication AT rossettimariavictoria sadenosyllmethionineitseffectonaminolevulinatedehydrataseandglutathioneinacuteethanolintoxication AT batllealciramariadelcarmen sadenosyllmethionineitseffectonaminolevulinatedehydrataseandglutathioneinacuteethanolintoxication
_version_	1768544871142916096

S-Adenosyl-L-methionine: Its effect on aminolevulinate dehydratase and glutathione in acute ethanol intoxication

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