Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment
Motor activity induced in the Circling Training test (CT) during a postnatal (PN) critical period of plasticity (PN30-37) produces a long-lasting decrease in the number of binding sites and mRNA expression levels of the dopamine D2 receptor (D2R) in rat striatum. Prenatal exposure to the antipsychot...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07365748_v29_n8_p855_SoizaReilly http://hdl.handle.net/20.500.12110/paper_07365748_v29_n8_p855_SoizaReilly |
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paper:paper_07365748_v29_n8_p855_SoizaReilly2023-06-08T15:44:11Z Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment Soiza Reilly, Mariano Azcurra, Julio Marcos Critical period of plasticity Development Dopamine D2 receptor Haloperidol Motor behavior Striatum dopamine 2 receptor haloperidol messenger RNA sodium chloride adulthood animal experiment animal tissue article binding site controlled study corpus striatum female gene expression gestation period instrumental conditioning learning male motor activity nerve cell plasticity nonhuman ontogeny perinatal period prenatal drug exposure priority journal progeny pup (rodent) rat receptor binding Animals Behavior, Animal Binding Sites Corpus Striatum Dopamine Dopamine Antagonists Female Fetus Gestational Age Haloperidol Humans Male Motor Activity Neuronal Plasticity Pregnancy Prenatal Exposure Delayed Effects Random Allocation Rats Rats, Sprague-Dawley Receptors, Dopamine D2 RNA, Messenger Animalia Rattus Motor activity induced in the Circling Training test (CT) during a postnatal (PN) critical period of plasticity (PN30-37) produces a long-lasting decrease in the number of binding sites and mRNA expression levels of the dopamine D2 receptor (D2R) in rat striatum. Prenatal exposure to the antipsychotic haloperidol also decreases postnatal levels of the striatal D2R in the offspring. We examined whether such fetal exposure to haloperidol could affect the activity-dependent reduction of the D2R system during the critical period. Half of the male offspring exposed to either haloperidol (2.5. mg/kg/day), i.p.) or saline during gestational days 5-18 were subjected to the CT during the critical period, while the remaining represented CT control animals. The adult number of binding sites and mRNA expression levels of the striatal D2R at PN90 were not changed by prenatal haloperidol treatment alone. On the other hand, only pups subjected to the CT during the critical period showed decreases in both studied parameters, regardless the prenatal treatment. These findings indicated that the postnatal reduction of the striatal D2R binding induced prenatally by haloperidol does not affect long-lasting activity-dependent plastic changes on the same receptor system elicited by motor activity in an ontogenetic critical period of plasticity in rat striatum. © 2011 ISDN. Fil:Soiza-Reilly, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Azcurra, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07365748_v29_n8_p855_SoizaReilly http://hdl.handle.net/20.500.12110/paper_07365748_v29_n8_p855_SoizaReilly |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Critical period of plasticity Development Dopamine D2 receptor Haloperidol Motor behavior Striatum dopamine 2 receptor haloperidol messenger RNA sodium chloride adulthood animal experiment animal tissue article binding site controlled study corpus striatum female gene expression gestation period instrumental conditioning learning male motor activity nerve cell plasticity nonhuman ontogeny perinatal period prenatal drug exposure priority journal progeny pup (rodent) rat receptor binding Animals Behavior, Animal Binding Sites Corpus Striatum Dopamine Dopamine Antagonists Female Fetus Gestational Age Haloperidol Humans Male Motor Activity Neuronal Plasticity Pregnancy Prenatal Exposure Delayed Effects Random Allocation Rats Rats, Sprague-Dawley Receptors, Dopamine D2 RNA, Messenger Animalia Rattus |
| spellingShingle |
Critical period of plasticity Development Dopamine D2 receptor Haloperidol Motor behavior Striatum dopamine 2 receptor haloperidol messenger RNA sodium chloride adulthood animal experiment animal tissue article binding site controlled study corpus striatum female gene expression gestation period instrumental conditioning learning male motor activity nerve cell plasticity nonhuman ontogeny perinatal period prenatal drug exposure priority journal progeny pup (rodent) rat receptor binding Animals Behavior, Animal Binding Sites Corpus Striatum Dopamine Dopamine Antagonists Female Fetus Gestational Age Haloperidol Humans Male Motor Activity Neuronal Plasticity Pregnancy Prenatal Exposure Delayed Effects Random Allocation Rats Rats, Sprague-Dawley Receptors, Dopamine D2 RNA, Messenger Animalia Rattus Soiza Reilly, Mariano Azcurra, Julio Marcos Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment |
| topic_facet |
Critical period of plasticity Development Dopamine D2 receptor Haloperidol Motor behavior Striatum dopamine 2 receptor haloperidol messenger RNA sodium chloride adulthood animal experiment animal tissue article binding site controlled study corpus striatum female gene expression gestation period instrumental conditioning learning male motor activity nerve cell plasticity nonhuman ontogeny perinatal period prenatal drug exposure priority journal progeny pup (rodent) rat receptor binding Animals Behavior, Animal Binding Sites Corpus Striatum Dopamine Dopamine Antagonists Female Fetus Gestational Age Haloperidol Humans Male Motor Activity Neuronal Plasticity Pregnancy Prenatal Exposure Delayed Effects Random Allocation Rats Rats, Sprague-Dawley Receptors, Dopamine D2 RNA, Messenger Animalia Rattus |
| description |
Motor activity induced in the Circling Training test (CT) during a postnatal (PN) critical period of plasticity (PN30-37) produces a long-lasting decrease in the number of binding sites and mRNA expression levels of the dopamine D2 receptor (D2R) in rat striatum. Prenatal exposure to the antipsychotic haloperidol also decreases postnatal levels of the striatal D2R in the offspring. We examined whether such fetal exposure to haloperidol could affect the activity-dependent reduction of the D2R system during the critical period. Half of the male offspring exposed to either haloperidol (2.5. mg/kg/day), i.p.) or saline during gestational days 5-18 were subjected to the CT during the critical period, while the remaining represented CT control animals. The adult number of binding sites and mRNA expression levels of the striatal D2R at PN90 were not changed by prenatal haloperidol treatment alone. On the other hand, only pups subjected to the CT during the critical period showed decreases in both studied parameters, regardless the prenatal treatment. These findings indicated that the postnatal reduction of the striatal D2R binding induced prenatally by haloperidol does not affect long-lasting activity-dependent plastic changes on the same receptor system elicited by motor activity in an ontogenetic critical period of plasticity in rat striatum. © 2011 ISDN. |
| author |
Soiza Reilly, Mariano Azcurra, Julio Marcos |
| author_facet |
Soiza Reilly, Mariano Azcurra, Julio Marcos |
| author_sort |
Soiza Reilly, Mariano |
| title |
Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment |
| title_short |
Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment |
| title_full |
Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment |
| title_fullStr |
Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment |
| title_full_unstemmed |
Activity-dependent reduction of dopamine D2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment |
| title_sort |
activity-dependent reduction of dopamine d2 receptors during a postnatal critical period of plasticity in rat striatum is not affected by prenatal haloperidol treatment |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07365748_v29_n8_p855_SoizaReilly http://hdl.handle.net/20.500.12110/paper_07365748_v29_n8_p855_SoizaReilly |
| work_keys_str_mv |
AT soizareillymariano activitydependentreductionofdopamined2receptorsduringapostnatalcriticalperiodofplasticityinratstriatumisnotaffectedbyprenatalhaloperidoltreatment AT azcurrajuliomarcos activitydependentreductionofdopamined2receptorsduringapostnatalcriticalperiodofplasticityinratstriatumisnotaffectedbyprenatalhaloperidoltreatment |
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1768545603923476480 |