Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus)

When a passing shadow is presented to the crab (Chasmagnathus granulatus), an escape response is elicited that habituates after repeated stimulation. Results of previous papers suggest that this habituation might be mediated by endogenous opiates, entailing the postulate that opiates may inhibit the...

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Autores principales: Romano, Arturo Gabriel, Lozada, Mariana
Publicado: 1989
Materias:
morphine
naloxone
opiate receptor
animal experiment
arthropod
crab
escape behavior
nonhuman
psychological aspect
Animal
Arousal
Brachyura
Dose-Response Relationship, Drug
Escape Reaction
Male
Morphine
Reaction Time
Receptors, Opioid
Support, Non-U.S. Gov't
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07357044_v103_n5_p1139_Maldonado
http://hdl.handle.net/20.500.12110/paper_07357044_v103_n5_p1139_Maldonado
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_07357044_v103_n5_p1139_Maldonado
record_format dspace
spelling paper:paper_07357044_v103_n5_p1139_Maldonado2023-06-08T15:44:07Z Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus) Romano, Arturo Gabriel Lozada, Mariana morphine naloxone opiate receptor animal experiment arthropod crab escape behavior nonhuman psychological aspect Animal Arousal Brachyura Dose-Response Relationship, Drug Escape Reaction Male Morphine Reaction Time Receptors, Opioid Support, Non-U.S. Gov't When a passing shadow is presented to the crab (Chasmagnathus granulatus), an escape response is elicited that habituates after repeated stimulation. Results of previous papers suggest that this habituation might be mediated by endogenous opiates, entailing the postulate that opiates may inhibit the response to a danger stimulus. This contention is tested herein. Two trials (T1, T2) of shadow stimulation were given 30 min apart, and the response activity was recorded. In Experiment 1 a range of morphine doses (0, 25, 50, 75, and 100 μg/g) were injected into crabs immediately after T1. Analysis of the M response values showed a morphine dose-dependent reduction in the crab's reactivity to the danger stimulus in T2. In Experiment 2, groups of crabs were injected with 1 of 4 solutions: saline, 70 μg/g morphine, 70 μg/g, morphine plus 1.6 μg/g naloxone, or 1.6 μg/g naloxone. Results suggest that morphine acts through an opiate receptor to inhibit the crab's response level to a danger stimulus. Three possible mechanisms of the morphine effect are discussed, and the most viable one suggests a central site of action. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lozada, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1989 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07357044_v103_n5_p1139_Maldonado http://hdl.handle.net/20.500.12110/paper_07357044_v103_n5_p1139_Maldonado
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic morphine
naloxone
opiate receptor
animal experiment
arthropod
crab
escape behavior
nonhuman
psychological aspect
Animal
Arousal
Brachyura
Dose-Response Relationship, Drug
Escape Reaction
Male
Morphine
Reaction Time
Receptors, Opioid
Support, Non-U.S. Gov't
spellingShingle morphine
naloxone
opiate receptor
animal experiment
arthropod
crab
escape behavior
nonhuman
psychological aspect
Animal
Arousal
Brachyura
Dose-Response Relationship, Drug
Escape Reaction
Male
Morphine
Reaction Time
Receptors, Opioid
Support, Non-U.S. Gov't
Romano, Arturo Gabriel
Lozada, Mariana
Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus)
topic_facet morphine
naloxone
opiate receptor
animal experiment
arthropod
crab
escape behavior
nonhuman
psychological aspect
Animal
Arousal
Brachyura
Dose-Response Relationship, Drug
Escape Reaction
Male
Morphine
Reaction Time
Receptors, Opioid
Support, Non-U.S. Gov't
description When a passing shadow is presented to the crab (Chasmagnathus granulatus), an escape response is elicited that habituates after repeated stimulation. Results of previous papers suggest that this habituation might be mediated by endogenous opiates, entailing the postulate that opiates may inhibit the response to a danger stimulus. This contention is tested herein. Two trials (T1, T2) of shadow stimulation were given 30 min apart, and the response activity was recorded. In Experiment 1 a range of morphine doses (0, 25, 50, 75, and 100 μg/g) were injected into crabs immediately after T1. Analysis of the M response values showed a morphine dose-dependent reduction in the crab's reactivity to the danger stimulus in T2. In Experiment 2, groups of crabs were injected with 1 of 4 solutions: saline, 70 μg/g morphine, 70 μg/g, morphine plus 1.6 μg/g naloxone, or 1.6 μg/g naloxone. Results suggest that morphine acts through an opiate receptor to inhibit the crab's response level to a danger stimulus. Three possible mechanisms of the morphine effect are discussed, and the most viable one suggests a central site of action.
author Romano, Arturo Gabriel
Lozada, Mariana
author_facet Romano, Arturo Gabriel
Lozada, Mariana
author_sort Romano, Arturo Gabriel
title Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus)
title_short Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus)
title_full Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus)
title_fullStr Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus)
title_full_unstemmed Opioid Action on Response Level to a Danger Stimulus in the Crab (Chasmagnathus granulatus)
title_sort opioid action on response level to a danger stimulus in the crab (chasmagnathus granulatus)
publishDate 1989
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07357044_v103_n5_p1139_Maldonado
http://hdl.handle.net/20.500.12110/paper_07357044_v103_n5_p1139_Maldonado
work_keys_str_mv AT romanoarturogabriel opioidactiononresponseleveltoadangerstimulusinthecrabchasmagnathusgranulatus
AT lozadamariana opioidactiononresponseleveltoadangerstimulusinthecrabchasmagnathusgranulatus
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