Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C

Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity.

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Detalles Bibliográficos
Autores principales:	Comin, María Julieta, Pujol, Carlos Alberto, Damonte, Elsa Beatriz, Rodríguez, Juan Bautista
Publicado:	1999
Materias:	aciclovir adenosine derivative guanosine derivative purine nucleoside animal cell antiviral activity article controlled study drug activity drug structure drug synthesis Herpes simplex virus 1 Herpes simplex virus 2 human human cell Human cytomegalovirus nonhuman
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07328311_v18_n10_p2219_Comin http://hdl.handle.net/20.500.12110/paper_07328311_v18_n10_p2219_Comin
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_07328311_v18_n10_p2219_Comin
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spelling	paper:paper_07328311_v18_n10_p2219_Comin2023-06-08T15:44:00Z Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C Comin, María Julieta Pujol, Carlos Alberto Damonte, Elsa Beatriz Rodríguez, Juan Bautista aciclovir adenosine derivative guanosine derivative purine nucleoside animal cell antiviral activity article controlled study drug activity drug structure drug synthesis Herpes simplex virus 1 Herpes simplex virus 2 human human cell Human cytomegalovirus nonhuman Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity. Fil:Comin, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1999 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07328311_v18_n10_p2219_Comin http://hdl.handle.net/20.500.12110/paper_07328311_v18_n10_p2219_Comin
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	aciclovir adenosine derivative guanosine derivative purine nucleoside animal cell antiviral activity article controlled study drug activity drug structure drug synthesis Herpes simplex virus 1 Herpes simplex virus 2 human human cell Human cytomegalovirus nonhuman
spellingShingle	aciclovir adenosine derivative guanosine derivative purine nucleoside animal cell antiviral activity article controlled study drug activity drug structure drug synthesis Herpes simplex virus 1 Herpes simplex virus 2 human human cell Human cytomegalovirus nonhuman Comin, María Julieta Pujol, Carlos Alberto Damonte, Elsa Beatriz Rodríguez, Juan Bautista Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C
topic_facet	aciclovir adenosine derivative guanosine derivative purine nucleoside animal cell antiviral activity article controlled study drug activity drug structure drug synthesis Herpes simplex virus 1 Herpes simplex virus 2 human human cell Human cytomegalovirus nonhuman
description	Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity.
author	Comin, María Julieta Pujol, Carlos Alberto Damonte, Elsa Beatriz Rodríguez, Juan Bautista
author_facet	Comin, María Julieta Pujol, Carlos Alberto Damonte, Elsa Beatriz Rodríguez, Juan Bautista
author_sort	Comin, María Julieta
title	Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C
title_short	Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C
title_full	Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C
title_fullStr	Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C
title_full_unstemmed	Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C
title_sort	synthesis of c-5'-nor-dideoxycarbanucleosides structurally related to neplanocin c
publishDate	1999
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07328311_v18_n10_p2219_Comin http://hdl.handle.net/20.500.12110/paper_07328311_v18_n10_p2219_Comin
work_keys_str_mv	AT cominmariajulieta synthesisofc5nordideoxycarbanucleosidesstructurallyrelatedtoneplanocinc AT pujolcarlosalberto synthesisofc5nordideoxycarbanucleosidesstructurallyrelatedtoneplanocinc AT damonteelsabeatriz synthesisofc5nordideoxycarbanucleosidesstructurallyrelatedtoneplanocinc AT rodriguezjuanbautista synthesisofc5nordideoxycarbanucleosidesstructurallyrelatedtoneplanocinc
_version_	1768543520077905920

Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C

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