Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster

Longevity is a typical quantitative trait which is influenced by multiple genes. Here we explore the genetic variation in longevity of Drosophila melanogaster in both mildly heat-stressed and control flies. Quantitative trait loci (QTL) analysis for longevity was performed in a single-sex environmen...

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Autores principales:	Defays, Raquel, Gomez, Federico Hernan, Sambucetti, Pablo Daniel, Scannapieco, Alejandra Carla, Norry, Fabian Marcelo
Publicado:	2011
Materias:	Hormesis Life span QTL Single-sex environment Thermal stress age distribution article controlled study Drosophila melanogaster environmental temperature female genetic analysis genetic variability heat stress hormesis insect genome lifespan longevity male nonhuman priority journal quantitative trait locus quantitative trait locus mapping recombinant inbred strain sex ratio temperature sensitivity Adaptation, Physiological Aging Animals Chromosome Mapping Gene Knockdown Techniques Genes, Insect Genetic Variation Heat-Shock Response Hot Temperature Longevity Quantitative Trait Loci
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v46_n10_p819_Defays http://hdl.handle.net/20.500.12110/paper_05315565_v46_n10_p819_Defays
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_05315565_v46_n10_p819_Defays
record_format	dspace
spelling	paper:paper_05315565_v46_n10_p819_Defays2023-06-08T15:41:13Z Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster Defays, Raquel Gomez, Federico Hernan Sambucetti, Pablo Daniel Scannapieco, Alejandra Carla Norry, Fabian Marcelo Hormesis Life span QTL Single-sex environment Thermal stress age distribution article controlled study Drosophila melanogaster environmental temperature female genetic analysis genetic variability heat stress hormesis insect genome lifespan longevity male nonhuman priority journal quantitative trait locus quantitative trait locus mapping recombinant inbred strain sex ratio temperature sensitivity Adaptation, Physiological Aging Animals Chromosome Mapping Drosophila melanogaster Gene Knockdown Techniques Genes, Insect Genetic Variation Heat-Shock Response Hot Temperature Longevity Quantitative Trait Loci Drosophila melanogaster Longevity is a typical quantitative trait which is influenced by multiple genes. Here we explore the genetic variation in longevity of Drosophila melanogaster in both mildly heat-stressed and control flies. Quantitative trait loci (QTL) analysis for longevity was performed in a single-sex environment at 25 °C with and without a mild heat-stress pre-treatment, using a previously reported set of recombinant inbred lines (RIL). QTL regions for longevity in heat-stressed flies overlapped with QTL for longevity in control flies. All longevity QTL co-localized with QTL for longevity identified in previous studies using very different sets of RIL in mixed sex environments, though the genome is nearly saturated with QTL for longevity when considering all previous studies. Heat stress decreased the number of significant QTL for longevity if compared to the control environment. Our mild heat-stress pre-treatment had a beneficial effect (hormesis) more often in shorter-lived than in longer-lived RIL. © 2011 Elsevier Inc. Fil:Defays, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gómez, F.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sambucetti, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Scannapieco, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Norry, F.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v46_n10_p819_Defays http://hdl.handle.net/20.500.12110/paper_05315565_v46_n10_p819_Defays
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Hormesis Life span QTL Single-sex environment Thermal stress age distribution article controlled study Drosophila melanogaster environmental temperature female genetic analysis genetic variability heat stress hormesis insect genome lifespan longevity male nonhuman priority journal quantitative trait locus quantitative trait locus mapping recombinant inbred strain sex ratio temperature sensitivity Adaptation, Physiological Aging Animals Chromosome Mapping Drosophila melanogaster Gene Knockdown Techniques Genes, Insect Genetic Variation Heat-Shock Response Hot Temperature Longevity Quantitative Trait Loci Drosophila melanogaster
spellingShingle	Hormesis Life span QTL Single-sex environment Thermal stress age distribution article controlled study Drosophila melanogaster environmental temperature female genetic analysis genetic variability heat stress hormesis insect genome lifespan longevity male nonhuman priority journal quantitative trait locus quantitative trait locus mapping recombinant inbred strain sex ratio temperature sensitivity Adaptation, Physiological Aging Animals Chromosome Mapping Drosophila melanogaster Gene Knockdown Techniques Genes, Insect Genetic Variation Heat-Shock Response Hot Temperature Longevity Quantitative Trait Loci Drosophila melanogaster Defays, Raquel Gomez, Federico Hernan Sambucetti, Pablo Daniel Scannapieco, Alejandra Carla Norry, Fabian Marcelo Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster
topic_facet	Hormesis Life span QTL Single-sex environment Thermal stress age distribution article controlled study Drosophila melanogaster environmental temperature female genetic analysis genetic variability heat stress hormesis insect genome lifespan longevity male nonhuman priority journal quantitative trait locus quantitative trait locus mapping recombinant inbred strain sex ratio temperature sensitivity Adaptation, Physiological Aging Animals Chromosome Mapping Drosophila melanogaster Gene Knockdown Techniques Genes, Insect Genetic Variation Heat-Shock Response Hot Temperature Longevity Quantitative Trait Loci Drosophila melanogaster
description	Longevity is a typical quantitative trait which is influenced by multiple genes. Here we explore the genetic variation in longevity of Drosophila melanogaster in both mildly heat-stressed and control flies. Quantitative trait loci (QTL) analysis for longevity was performed in a single-sex environment at 25 °C with and without a mild heat-stress pre-treatment, using a previously reported set of recombinant inbred lines (RIL). QTL regions for longevity in heat-stressed flies overlapped with QTL for longevity in control flies. All longevity QTL co-localized with QTL for longevity identified in previous studies using very different sets of RIL in mixed sex environments, though the genome is nearly saturated with QTL for longevity when considering all previous studies. Heat stress decreased the number of significant QTL for longevity if compared to the control environment. Our mild heat-stress pre-treatment had a beneficial effect (hormesis) more often in shorter-lived than in longer-lived RIL. © 2011 Elsevier Inc.
author	Defays, Raquel Gomez, Federico Hernan Sambucetti, Pablo Daniel Scannapieco, Alejandra Carla Norry, Fabian Marcelo
author_facet	Defays, Raquel Gomez, Federico Hernan Sambucetti, Pablo Daniel Scannapieco, Alejandra Carla Norry, Fabian Marcelo
author_sort	Defays, Raquel
title	Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster
title_short	Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster
title_full	Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster
title_fullStr	Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster
title_full_unstemmed	Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster
title_sort	quantitative trait loci for longevity in heat-stressed drosophila melanogaster
publishDate	2011
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v46_n10_p819_Defays http://hdl.handle.net/20.500.12110/paper_05315565_v46_n10_p819_Defays
work_keys_str_mv	AT defaysraquel quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster AT gomezfedericohernan quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster AT sambucettipablodaniel quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster AT scannapiecoalejandracarla quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster AT norryfabianmarcelo quantitativetraitlociforlongevityinheatstresseddrosophilamelanogaster
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Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster

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