Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals
The 70 kDa heat-shock protein (Hsp70) exhibits a broad range of chaperone functions that respond both to internal and external stresses, and its heat-induced expression both declines with age and reduces age-specific mortality rates. Here we test for changes in both longevity and the level of Hsp70-...
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2003
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v38_n6_p673_Norry http://hdl.handle.net/20.500.12110/paper_05315565_v38_n6_p673_Norry |
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paper:paper_05315565_v38_n6_p673_Norry2023-06-08T15:41:12Z Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals Norry, Fabian Marcelo Drosophila Heat-stress resistance Hsp70 Longevity Truncation selection chaperone heat shock protein 70 aging article controlled study Drosophila melanogaster female heat stress heritability lifespan longevity male nonhuman priority journal protein expression protein function regulatory mechanism temperature sensitivity Melanogaster The 70 kDa heat-shock protein (Hsp70) exhibits a broad range of chaperone functions that respond both to internal and external stresses, and its heat-induced expression both declines with age and reduces age-specific mortality rates. Here we test for changes in both longevity and the level of Hsp70-induced expression as correlated responses to selection on both heat-stress resistance and longevity in D. melanogaster. Three replicated H lines were heat-stress selected and compared to their respective non-selected controls (C lines) in the 25th generation of heat-stress selection. The direct response in heat-stress resistance was 56% in males and 38% in females. Heat-stress selection improved longevity in males at normal temperatures. All lines were subsequently subjected to one generation of truncation selection on longevity (selection intensity, i=1.28 for H lines and 1.36 for C lines). The heat-induced Hsp70 expression seems to increase very weakly by heat-stress selection but shows a dramatic and persistent decline by selecting for long-lived flies. A mechanism of longevity selection, involving changes in Hsp70 regulation, is suggested. © 2003 Elsevier Science Inc. All rights reserved. Fil:Norry, F.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v38_n6_p673_Norry http://hdl.handle.net/20.500.12110/paper_05315565_v38_n6_p673_Norry |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Drosophila Heat-stress resistance Hsp70 Longevity Truncation selection chaperone heat shock protein 70 aging article controlled study Drosophila melanogaster female heat stress heritability lifespan longevity male nonhuman priority journal protein expression protein function regulatory mechanism temperature sensitivity Melanogaster |
| spellingShingle |
Drosophila Heat-stress resistance Hsp70 Longevity Truncation selection chaperone heat shock protein 70 aging article controlled study Drosophila melanogaster female heat stress heritability lifespan longevity male nonhuman priority journal protein expression protein function regulatory mechanism temperature sensitivity Melanogaster Norry, Fabian Marcelo Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals |
| topic_facet |
Drosophila Heat-stress resistance Hsp70 Longevity Truncation selection chaperone heat shock protein 70 aging article controlled study Drosophila melanogaster female heat stress heritability lifespan longevity male nonhuman priority journal protein expression protein function regulatory mechanism temperature sensitivity Melanogaster |
| description |
The 70 kDa heat-shock protein (Hsp70) exhibits a broad range of chaperone functions that respond both to internal and external stresses, and its heat-induced expression both declines with age and reduces age-specific mortality rates. Here we test for changes in both longevity and the level of Hsp70-induced expression as correlated responses to selection on both heat-stress resistance and longevity in D. melanogaster. Three replicated H lines were heat-stress selected and compared to their respective non-selected controls (C lines) in the 25th generation of heat-stress selection. The direct response in heat-stress resistance was 56% in males and 38% in females. Heat-stress selection improved longevity in males at normal temperatures. All lines were subsequently subjected to one generation of truncation selection on longevity (selection intensity, i=1.28 for H lines and 1.36 for C lines). The heat-induced Hsp70 expression seems to increase very weakly by heat-stress selection but shows a dramatic and persistent decline by selecting for long-lived flies. A mechanism of longevity selection, involving changes in Hsp70 regulation, is suggested. © 2003 Elsevier Science Inc. All rights reserved. |
| author |
Norry, Fabian Marcelo |
| author_facet |
Norry, Fabian Marcelo |
| author_sort |
Norry, Fabian Marcelo |
| title |
Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals |
| title_short |
Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals |
| title_full |
Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals |
| title_fullStr |
Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals |
| title_full_unstemmed |
Heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals |
| title_sort |
heat-induced expression of a molecular chaperone decreases by selecting for long-lived individuals |
| publishDate |
2003 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_05315565_v38_n6_p673_Norry http://hdl.handle.net/20.500.12110/paper_05315565_v38_n6_p673_Norry |
| work_keys_str_mv |
AT norryfabianmarcelo heatinducedexpressionofamolecularchaperonedecreasesbyselectingforlonglivedindividuals |
| _version_ |
1768543087981756416 |