Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons
We examined membrane properties and synaptic responses of neurons in the mouse lateral superior olivary nucleus (LSO). Two clear populations were identified consistent with: principal neurons which are involved in detecting interaural intensity differences (IIDs) and efferent neurons of the lateral...
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2010
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785955_v270_n1-2_p119_Sterenborg http://hdl.handle.net/20.500.12110/paper_03785955_v270_n1-2_p119_Sterenborg |
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paper:paper_03785955_v270_n1-2_p119_Sterenborg2023-06-08T15:40:24Z Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons Uchitel, Osvaldo Daniel 4 aminobutyric acid receptor AMPA receptor glycine receptor animal cell animal tissue article cochlear nucleus controlled study depolarization excitatory postsynaptic potential hyperpolarization inhibitory postsynaptic potential latent period lateral olivocochlear nucleus lateral superior olivary nucleus mouse nerve potential nonhuman potassium current priority journal superior olivary nucleus synaptic transmission Animals Auditory Pathways Cochlear Nerve Cyclic Nucleotide-Gated Cation Channels Excitatory Postsynaptic Potentials Glutamic Acid Glycine Inhibitory Postsynaptic Potentials Kinetics Mice Mice, Inbred CBA Neurons Neurons, Efferent Neurotransmitter Agents Olivary Nucleus Patch-Clamp Techniques Potassium Potassium Channels Reaction Time We examined membrane properties and synaptic responses of neurons in the mouse lateral superior olivary nucleus (LSO). Two clear populations were identified consistent with: principal neurons which are involved in detecting interaural intensity differences (IIDs) and efferent neurons of the lateral olivocochlear (LOC) system which project to the cochlea. Principal neurons fired a short latency action potential (AP) often followed by an AP train during maintained depolarization. They possessed sustained outward K + currents, with little or no transient K + current (I A) and a prominent hyperpolarization-activated non-specific cation conductance, I H. On depolarization, LOC neurons exhibited a characteristic delay to the first AP. These neurons possessed a prominent transient outward current I A, but had no I H. Both LOC and principal neurons received glutamatergic and glycinergic synaptic inputs. LOC synaptic responses decayed more slowly than those of principal neurons; the mean decay time constant of AMPA receptor-mediated EPSCs was around 1 ms in principal neurons and 4 ms in LOC neurons. Decay time constants for glycinergic IPSCs were around 5 ms in principal neurons and 10 ms in LOC neurons. We conclude that principal cells receive fast synaptic responses appropriate for integration of IID inputs, while the LOC cells possess excitatory and inhibitory receptors with much slower kinetics. © 2010 Elsevier B.V. Fil:Uchitel, O.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785955_v270_n1-2_p119_Sterenborg http://hdl.handle.net/20.500.12110/paper_03785955_v270_n1-2_p119_Sterenborg |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
4 aminobutyric acid receptor AMPA receptor glycine receptor animal cell animal tissue article cochlear nucleus controlled study depolarization excitatory postsynaptic potential hyperpolarization inhibitory postsynaptic potential latent period lateral olivocochlear nucleus lateral superior olivary nucleus mouse nerve potential nonhuman potassium current priority journal superior olivary nucleus synaptic transmission Animals Auditory Pathways Cochlear Nerve Cyclic Nucleotide-Gated Cation Channels Excitatory Postsynaptic Potentials Glutamic Acid Glycine Inhibitory Postsynaptic Potentials Kinetics Mice Mice, Inbred CBA Neurons Neurons, Efferent Neurotransmitter Agents Olivary Nucleus Patch-Clamp Techniques Potassium Potassium Channels Reaction Time |
| spellingShingle |
4 aminobutyric acid receptor AMPA receptor glycine receptor animal cell animal tissue article cochlear nucleus controlled study depolarization excitatory postsynaptic potential hyperpolarization inhibitory postsynaptic potential latent period lateral olivocochlear nucleus lateral superior olivary nucleus mouse nerve potential nonhuman potassium current priority journal superior olivary nucleus synaptic transmission Animals Auditory Pathways Cochlear Nerve Cyclic Nucleotide-Gated Cation Channels Excitatory Postsynaptic Potentials Glutamic Acid Glycine Inhibitory Postsynaptic Potentials Kinetics Mice Mice, Inbred CBA Neurons Neurons, Efferent Neurotransmitter Agents Olivary Nucleus Patch-Clamp Techniques Potassium Potassium Channels Reaction Time Uchitel, Osvaldo Daniel Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons |
| topic_facet |
4 aminobutyric acid receptor AMPA receptor glycine receptor animal cell animal tissue article cochlear nucleus controlled study depolarization excitatory postsynaptic potential hyperpolarization inhibitory postsynaptic potential latent period lateral olivocochlear nucleus lateral superior olivary nucleus mouse nerve potential nonhuman potassium current priority journal superior olivary nucleus synaptic transmission Animals Auditory Pathways Cochlear Nerve Cyclic Nucleotide-Gated Cation Channels Excitatory Postsynaptic Potentials Glutamic Acid Glycine Inhibitory Postsynaptic Potentials Kinetics Mice Mice, Inbred CBA Neurons Neurons, Efferent Neurotransmitter Agents Olivary Nucleus Patch-Clamp Techniques Potassium Potassium Channels Reaction Time |
| description |
We examined membrane properties and synaptic responses of neurons in the mouse lateral superior olivary nucleus (LSO). Two clear populations were identified consistent with: principal neurons which are involved in detecting interaural intensity differences (IIDs) and efferent neurons of the lateral olivocochlear (LOC) system which project to the cochlea. Principal neurons fired a short latency action potential (AP) often followed by an AP train during maintained depolarization. They possessed sustained outward K + currents, with little or no transient K + current (I A) and a prominent hyperpolarization-activated non-specific cation conductance, I H. On depolarization, LOC neurons exhibited a characteristic delay to the first AP. These neurons possessed a prominent transient outward current I A, but had no I H. Both LOC and principal neurons received glutamatergic and glycinergic synaptic inputs. LOC synaptic responses decayed more slowly than those of principal neurons; the mean decay time constant of AMPA receptor-mediated EPSCs was around 1 ms in principal neurons and 4 ms in LOC neurons. Decay time constants for glycinergic IPSCs were around 5 ms in principal neurons and 10 ms in LOC neurons. We conclude that principal cells receive fast synaptic responses appropriate for integration of IID inputs, while the LOC cells possess excitatory and inhibitory receptors with much slower kinetics. © 2010 Elsevier B.V. |
| author |
Uchitel, Osvaldo Daniel |
| author_facet |
Uchitel, Osvaldo Daniel |
| author_sort |
Uchitel, Osvaldo Daniel |
| title |
Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons |
| title_short |
Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons |
| title_full |
Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons |
| title_fullStr |
Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons |
| title_full_unstemmed |
Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons |
| title_sort |
lateral olivocochlear (loc) neurons of the mouse lso receive excitatory and inhibitory synaptic inputs with slower kinetics than lso principal neurons |
| publishDate |
2010 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03785955_v270_n1-2_p119_Sterenborg http://hdl.handle.net/20.500.12110/paper_03785955_v270_n1-2_p119_Sterenborg |
| work_keys_str_mv |
AT uchitelosvaldodaniel lateralolivocochlearlocneuronsofthemouselsoreceiveexcitatoryandinhibitorysynapticinputswithslowerkineticsthanlsoprincipalneurons |
| _version_ |
1768542416214687744 |