Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes

Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligo-dendrocyte cell sha...

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Autores principales:	Thomas, María Gabriela, Santa Coloma, Tomás Antonio, Boccaccio, Graciela Lidia
Publicado:	2002
Materias:	ML-7 ML-9 MLCK Myelin Myosin II Oligodendrocyte processes myosin IIA myosin light chain kinase inhibitor protein ml 7 protein ml 9 unclassified drug animal tissue article cell activity cell adhesion cell culture cell differentiation cell growth cell maturation cell shape central nervous system controlled study immunohistochemistry myelination nonhuman oligodendroglia phosphorylation priority journal rat Animals Azepines Enzyme Inhibitors Myosin-Light-Chain Kinase Naphthalenes Oligodendroglia Phosphorylation Rats Rats, Wistar Animalia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03643190_v27_n11_p1305_Thomas http://hdl.handle.net/20.500.12110/paper_03643190_v27_n11_p1305_Thomas
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03643190_v27_n11_p1305_Thomas
record_format	dspace
spelling	paper:paper_03643190_v27_n11_p1305_Thomas2023-06-08T15:35:35Z Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes Thomas, María Gabriela Santa Coloma, Tomás Antonio Boccaccio, Graciela Lidia ML-7 ML-9 MLCK Myelin Myosin II Oligodendrocyte processes myosin IIA myosin light chain kinase inhibitor protein ml 7 protein ml 9 unclassified drug animal tissue article cell activity cell adhesion cell culture cell differentiation cell growth cell maturation cell shape central nervous system controlled study immunohistochemistry myelination nonhuman oligodendroglia phosphorylation priority journal rat Animals Azepines Enzyme Inhibitors Myosin-Light-Chain Kinase Naphthalenes Oligodendroglia Phosphorylation Rats Rats, Wistar Animalia Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligo-dendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA. Fil:Thomas, M.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Santa Coloma, T.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Boccaccio, G.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03643190_v27_n11_p1305_Thomas http://hdl.handle.net/20.500.12110/paper_03643190_v27_n11_p1305_Thomas
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	ML-7 ML-9 MLCK Myelin Myosin II Oligodendrocyte processes myosin IIA myosin light chain kinase inhibitor protein ml 7 protein ml 9 unclassified drug animal tissue article cell activity cell adhesion cell culture cell differentiation cell growth cell maturation cell shape central nervous system controlled study immunohistochemistry myelination nonhuman oligodendroglia phosphorylation priority journal rat Animals Azepines Enzyme Inhibitors Myosin-Light-Chain Kinase Naphthalenes Oligodendroglia Phosphorylation Rats Rats, Wistar Animalia
spellingShingle	ML-7 ML-9 MLCK Myelin Myosin II Oligodendrocyte processes myosin IIA myosin light chain kinase inhibitor protein ml 7 protein ml 9 unclassified drug animal tissue article cell activity cell adhesion cell culture cell differentiation cell growth cell maturation cell shape central nervous system controlled study immunohistochemistry myelination nonhuman oligodendroglia phosphorylation priority journal rat Animals Azepines Enzyme Inhibitors Myosin-Light-Chain Kinase Naphthalenes Oligodendroglia Phosphorylation Rats Rats, Wistar Animalia Thomas, María Gabriela Santa Coloma, Tomás Antonio Boccaccio, Graciela Lidia Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
topic_facet	ML-7 ML-9 MLCK Myelin Myosin II Oligodendrocyte processes myosin IIA myosin light chain kinase inhibitor protein ml 7 protein ml 9 unclassified drug animal tissue article cell activity cell adhesion cell culture cell differentiation cell growth cell maturation cell shape central nervous system controlled study immunohistochemistry myelination nonhuman oligodendroglia phosphorylation priority journal rat Animals Azepines Enzyme Inhibitors Myosin-Light-Chain Kinase Naphthalenes Oligodendroglia Phosphorylation Rats Rats, Wistar Animalia
description	Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligo-dendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA.
author	Thomas, María Gabriela Santa Coloma, Tomás Antonio Boccaccio, Graciela Lidia
author_facet	Thomas, María Gabriela Santa Coloma, Tomás Antonio Boccaccio, Graciela Lidia
author_sort	Thomas, María Gabriela
title	Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
title_short	Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
title_full	Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
title_fullStr	Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
title_full_unstemmed	Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
title_sort	myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes
publishDate	2002
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03643190_v27_n11_p1305_Thomas http://hdl.handle.net/20.500.12110/paper_03643190_v27_n11_p1305_Thomas
work_keys_str_mv	AT thomasmariagabriela myosinlightchainkinaseinhibitorsinduceretractionofmatureoligodendrocyteprocesses AT santacolomatomasantonio myosinlightchainkinaseinhibitorsinduceretractionofmatureoligodendrocyteprocesses AT boccacciogracielalidia myosinlightchainkinaseinhibitorsinduceretractionofmatureoligodendrocyteprocesses
_version_	1768545145760776192

Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes

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