Use of antiepileptic drugs in nontraumatic neurosurgical procedures: Is there any best route and time of administration?
We assessed in 15 consecutive patients the best route and time of administration for phenytoin (PHT) prophylaxis in neurosurgical procedures. We also correlated PHT levels in serum and cerebrospinal fluid after oral and parenteral loading doses. The mean PHT level was 13.9 μg/ml in serum and 2.03 μg...
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1997
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03625664_v20_n5_p438_Rabinowicz http://hdl.handle.net/20.500.12110/paper_03625664_v20_n5_p438_Rabinowicz |
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paper:paper_03625664_v20_n5_p438_Rabinowicz2023-06-08T15:35:25Z Use of antiepileptic drugs in nontraumatic neurosurgical procedures: Is there any best route and time of administration? Antiepileptic drugs Neurosurgery Phenytoin Prophylaxis anticonvulsive agent phenytoin adult aged article brain arteriovenous malformation brain artery aneurysm brain tumor clinical article clinical trial controlled clinical trial controlled study dose response drug blood level drug cerebrospinal fluid level epilepsy female head injury human intravenous drug administration male middle cerebral artery neurosurgery oral drug administration priority journal randomized controlled trial We assessed in 15 consecutive patients the best route and time of administration for phenytoin (PHT) prophylaxis in neurosurgical procedures. We also correlated PHT levels in serum and cerebrospinal fluid after oral and parenteral loading doses. The mean PHT level was 13.9 μg/ml in serum and 2.03 μg/ml in cerebrospinal fluid (CSF), with a significant correlation between levels in both compartments (r = 0.73, p <0.01). Mean PHT levels among the different groups were not statistically significant. We conclude that therapeutic levels of PHT in CSF can be achieved independently of the route of administration, as long as accepted loading doses are used. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03625664_v20_n5_p438_Rabinowicz http://hdl.handle.net/20.500.12110/paper_03625664_v20_n5_p438_Rabinowicz |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antiepileptic drugs Neurosurgery Phenytoin Prophylaxis anticonvulsive agent phenytoin adult aged article brain arteriovenous malformation brain artery aneurysm brain tumor clinical article clinical trial controlled clinical trial controlled study dose response drug blood level drug cerebrospinal fluid level epilepsy female head injury human intravenous drug administration male middle cerebral artery neurosurgery oral drug administration priority journal randomized controlled trial |
| spellingShingle |
Antiepileptic drugs Neurosurgery Phenytoin Prophylaxis anticonvulsive agent phenytoin adult aged article brain arteriovenous malformation brain artery aneurysm brain tumor clinical article clinical trial controlled clinical trial controlled study dose response drug blood level drug cerebrospinal fluid level epilepsy female head injury human intravenous drug administration male middle cerebral artery neurosurgery oral drug administration priority journal randomized controlled trial Use of antiepileptic drugs in nontraumatic neurosurgical procedures: Is there any best route and time of administration? |
| topic_facet |
Antiepileptic drugs Neurosurgery Phenytoin Prophylaxis anticonvulsive agent phenytoin adult aged article brain arteriovenous malformation brain artery aneurysm brain tumor clinical article clinical trial controlled clinical trial controlled study dose response drug blood level drug cerebrospinal fluid level epilepsy female head injury human intravenous drug administration male middle cerebral artery neurosurgery oral drug administration priority journal randomized controlled trial |
| description |
We assessed in 15 consecutive patients the best route and time of administration for phenytoin (PHT) prophylaxis in neurosurgical procedures. We also correlated PHT levels in serum and cerebrospinal fluid after oral and parenteral loading doses. The mean PHT level was 13.9 μg/ml in serum and 2.03 μg/ml in cerebrospinal fluid (CSF), with a significant correlation between levels in both compartments (r = 0.73, p <0.01). Mean PHT levels among the different groups were not statistically significant. We conclude that therapeutic levels of PHT in CSF can be achieved independently of the route of administration, as long as accepted loading doses are used. |
| title |
Use of antiepileptic drugs in nontraumatic neurosurgical procedures: Is there any best route and time of administration? |
| title_short |
Use of antiepileptic drugs in nontraumatic neurosurgical procedures: Is there any best route and time of administration? |
| title_full |
Use of antiepileptic drugs in nontraumatic neurosurgical procedures: Is there any best route and time of administration? |
| title_fullStr |
Use of antiepileptic drugs in nontraumatic neurosurgical procedures: Is there any best route and time of administration? |
| title_full_unstemmed |
Use of antiepileptic drugs in nontraumatic neurosurgical procedures: Is there any best route and time of administration? |
| title_sort |
use of antiepileptic drugs in nontraumatic neurosurgical procedures: is there any best route and time of administration? |
| publishDate |
1997 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03625664_v20_n5_p438_Rabinowicz http://hdl.handle.net/20.500.12110/paper_03625664_v20_n5_p438_Rabinowicz |
| _version_ |
1768544733091594240 |