Changes in neostriatal and hippocampal synaptic densities in perinatal asphyctic male and female young rats: Role of hypothermia

Perinatal asphyxia (PA) may cause long-term neurological and psychiatric diseases. We evaluated, by ethanolic phosphotungstic acid (E-PTA) staining, whether PA affects postsynaptic densities (PSDs), ultrastructure of neostriatum and hippocampus of 45-day-old post-PA male and female rats. PA was indu...

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Autor principal:	Cebral, Elisa
Publicado:	2011
Materias:	Hippocampus Hypothermia Neostriatum Perinatal asphyxia Postsynaptic density Rats phosphotungstic acid animal experiment animal model animal tissue article brain protection controlled study corpus striatum female fetus hippocampus induced hypothermia male neostriatum nonhuman perinatal asphyxia postsynaptic density priority journal rat sex difference thickness uterus horn Animals Animals, Newborn Asphyxia Female Hypothermia, Induced Male Post-Synaptic Density Pregnancy Rats, Sprague-Dawley Synapses
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03619230_v84_n1_p31_Cebral http://hdl.handle.net/20.500.12110/paper_03619230_v84_n1_p31_Cebral
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03619230_v84_n1_p31_Cebral
record_format	dspace
spelling	paper:paper_03619230_v84_n1_p31_Cebral2023-06-08T15:34:56Z Changes in neostriatal and hippocampal synaptic densities in perinatal asphyctic male and female young rats: Role of hypothermia Cebral, Elisa Hippocampus Hypothermia Neostriatum Perinatal asphyxia Postsynaptic density Rats phosphotungstic acid animal experiment animal model animal tissue article brain protection controlled study corpus striatum female fetus hippocampus induced hypothermia male neostriatum nonhuman perinatal asphyxia postsynaptic density priority journal rat sex difference thickness uterus horn Animals Animals, Newborn Asphyxia Female Hippocampus Hypothermia, Induced Male Neostriatum Post-Synaptic Density Pregnancy Rats Rats, Sprague-Dawley Synapses Perinatal asphyxia (PA) may cause long-term neurological and psychiatric diseases. We evaluated, by ethanolic phosphotungstic acid (E-PTA) staining, whether PA affects postsynaptic densities (PSDs), ultrastructure of neostriatum and hippocampus of 45-day-old post-PA male and female rats. PA was induced by placing the uterine horns containing the fetuses in a 37°C bath for 10, 15, 19 and 20. min and a 15°C bath for 20. min (hypothermia). Striatal synaptic disorganization and PSDs thickness increase were evident after 10 and 19. min of PA in male and female rats, respectively, but striatal female PSDs thickness was lower than in males. These changes were associated with increments of the PSDs area in both sexes at 19 and 20. min PA. Thickness and PSDs area from hippocampal PA males was affected more negatively than in females. Intrahypoxic hypothermia was able to protect the brain from effects of PA. In conclusion, early PA affects neostriatal and hippocampal PSDs in a time and sex-dependent manner, while hypothermia during asphyxia is able to prevent synaptic changes by providing protection from damage. © 2010. Fil:Cebral, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03619230_v84_n1_p31_Cebral http://hdl.handle.net/20.500.12110/paper_03619230_v84_n1_p31_Cebral
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Hippocampus Hypothermia Neostriatum Perinatal asphyxia Postsynaptic density Rats phosphotungstic acid animal experiment animal model animal tissue article brain protection controlled study corpus striatum female fetus hippocampus induced hypothermia male neostriatum nonhuman perinatal asphyxia postsynaptic density priority journal rat sex difference thickness uterus horn Animals Animals, Newborn Asphyxia Female Hippocampus Hypothermia, Induced Male Neostriatum Post-Synaptic Density Pregnancy Rats Rats, Sprague-Dawley Synapses
spellingShingle	Hippocampus Hypothermia Neostriatum Perinatal asphyxia Postsynaptic density Rats phosphotungstic acid animal experiment animal model animal tissue article brain protection controlled study corpus striatum female fetus hippocampus induced hypothermia male neostriatum nonhuman perinatal asphyxia postsynaptic density priority journal rat sex difference thickness uterus horn Animals Animals, Newborn Asphyxia Female Hippocampus Hypothermia, Induced Male Neostriatum Post-Synaptic Density Pregnancy Rats Rats, Sprague-Dawley Synapses Cebral, Elisa Changes in neostriatal and hippocampal synaptic densities in perinatal asphyctic male and female young rats: Role of hypothermia
topic_facet	Hippocampus Hypothermia Neostriatum Perinatal asphyxia Postsynaptic density Rats phosphotungstic acid animal experiment animal model animal tissue article brain protection controlled study corpus striatum female fetus hippocampus induced hypothermia male neostriatum nonhuman perinatal asphyxia postsynaptic density priority journal rat sex difference thickness uterus horn Animals Animals, Newborn Asphyxia Female Hippocampus Hypothermia, Induced Male Neostriatum Post-Synaptic Density Pregnancy Rats Rats, Sprague-Dawley Synapses
description	Perinatal asphyxia (PA) may cause long-term neurological and psychiatric diseases. We evaluated, by ethanolic phosphotungstic acid (E-PTA) staining, whether PA affects postsynaptic densities (PSDs), ultrastructure of neostriatum and hippocampus of 45-day-old post-PA male and female rats. PA was induced by placing the uterine horns containing the fetuses in a 37°C bath for 10, 15, 19 and 20. min and a 15°C bath for 20. min (hypothermia). Striatal synaptic disorganization and PSDs thickness increase were evident after 10 and 19. min of PA in male and female rats, respectively, but striatal female PSDs thickness was lower than in males. These changes were associated with increments of the PSDs area in both sexes at 19 and 20. min PA. Thickness and PSDs area from hippocampal PA males was affected more negatively than in females. Intrahypoxic hypothermia was able to protect the brain from effects of PA. In conclusion, early PA affects neostriatal and hippocampal PSDs in a time and sex-dependent manner, while hypothermia during asphyxia is able to prevent synaptic changes by providing protection from damage. © 2010.
author	Cebral, Elisa
author_facet	Cebral, Elisa
author_sort	Cebral, Elisa
title	Changes in neostriatal and hippocampal synaptic densities in perinatal asphyctic male and female young rats: Role of hypothermia
title_short	Changes in neostriatal and hippocampal synaptic densities in perinatal asphyctic male and female young rats: Role of hypothermia
title_full	Changes in neostriatal and hippocampal synaptic densities in perinatal asphyctic male and female young rats: Role of hypothermia
title_fullStr	Changes in neostriatal and hippocampal synaptic densities in perinatal asphyctic male and female young rats: Role of hypothermia
title_full_unstemmed	Changes in neostriatal and hippocampal synaptic densities in perinatal asphyctic male and female young rats: Role of hypothermia
title_sort	changes in neostriatal and hippocampal synaptic densities in perinatal asphyctic male and female young rats: role of hypothermia
publishDate	2011
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03619230_v84_n1_p31_Cebral http://hdl.handle.net/20.500.12110/paper_03619230_v84_n1_p31_Cebral
work_keys_str_mv	AT cebralelisa changesinneostriatalandhippocampalsynapticdensitiesinperinatalasphycticmaleandfemaleyoungratsroleofhypothermia
_version_	1768545145026772992

Changes in neostriatal and hippocampal synaptic densities in perinatal asphyctic male and female young rats: Role of hypothermia

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