Calcium spikes in a leech nonspiking neuron

The NS neurons are nonspiking cells, present as pairs in each midbody ganglion of the leech nervous system, which display a very extensive arborization. They were shown to regulate the coactivation of motoneurons. Here we have investigated the electrophysiological properties of these neurons under t...

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Autores principales:	Rela, Lorena, Yang, Sung Min, Szczupak, Lidia
Publicado:	2009
Materias:	Calcium spikes Low threshold voltage-dependent calcium conductance N-methyl-d-glucamine Nonspiking neuron Postinhibitory rebound calcium potassium animal article cell membrane potential leech metabolism nerve cell nerve conduction patch clamp physiology Animals Calcium Leeches Membrane Potentials Neural Conduction Neurons Patch-Clamp Techniques Potassium
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03407594_v195_n2_p139_Rela http://hdl.handle.net/20.500.12110/paper_03407594_v195_n2_p139_Rela
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03407594_v195_n2_p139_Rela
record_format	dspace
spelling	paper:paper_03407594_v195_n2_p139_Rela2023-06-08T15:34:23Z Calcium spikes in a leech nonspiking neuron Rela, Lorena Yang, Sung Min Szczupak, Lidia Calcium spikes Low threshold voltage-dependent calcium conductance N-methyl-d-glucamine Nonspiking neuron Postinhibitory rebound calcium potassium animal article cell membrane potential leech metabolism nerve cell nerve conduction patch clamp physiology Animals Calcium Leeches Membrane Potentials Neural Conduction Neurons Patch-Clamp Techniques Potassium The NS neurons are nonspiking cells, present as pairs in each midbody ganglion of the leech nervous system, which display a very extensive arborization. They were shown to regulate the coactivation of motoneurons. Here we have investigated the electrophysiological properties of these neurons under the hypothesis that transmission along the extensive neurites requires the aid of voltage-dependent conductances. The results indicate that NS neurons respond to electrical stimulation with a spike-like event, which was not an all-or-none but rather a graded phenomenon that depended on the intensity and duration of the electrical stimulus. The spike-like response was activated at a membrane potential of approximately -50 mV; its amplitude was a logarithmic function of the extracellular Ca 2+ concentration and was unaffected by a broad range of changes in the extracellular Na + concentration; intracellular application of tetraethylammonium (TEA) caused a large increase in its amplitude and duration. These data indicate that NS neurons bear voltage-dependent low-threshold Ca 2+ and TEA-sensitive K + conductances that could contribute to shaping synaptic signals, or transmission along the extensive neuritic tree. © 2008 Springer-Verlag. Fil:Rela, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Yang, S.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Szczupak, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03407594_v195_n2_p139_Rela http://hdl.handle.net/20.500.12110/paper_03407594_v195_n2_p139_Rela
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Calcium spikes Low threshold voltage-dependent calcium conductance N-methyl-d-glucamine Nonspiking neuron Postinhibitory rebound calcium potassium animal article cell membrane potential leech metabolism nerve cell nerve conduction patch clamp physiology Animals Calcium Leeches Membrane Potentials Neural Conduction Neurons Patch-Clamp Techniques Potassium
spellingShingle	Calcium spikes Low threshold voltage-dependent calcium conductance N-methyl-d-glucamine Nonspiking neuron Postinhibitory rebound calcium potassium animal article cell membrane potential leech metabolism nerve cell nerve conduction patch clamp physiology Animals Calcium Leeches Membrane Potentials Neural Conduction Neurons Patch-Clamp Techniques Potassium Rela, Lorena Yang, Sung Min Szczupak, Lidia Calcium spikes in a leech nonspiking neuron
topic_facet	Calcium spikes Low threshold voltage-dependent calcium conductance N-methyl-d-glucamine Nonspiking neuron Postinhibitory rebound calcium potassium animal article cell membrane potential leech metabolism nerve cell nerve conduction patch clamp physiology Animals Calcium Leeches Membrane Potentials Neural Conduction Neurons Patch-Clamp Techniques Potassium
description	The NS neurons are nonspiking cells, present as pairs in each midbody ganglion of the leech nervous system, which display a very extensive arborization. They were shown to regulate the coactivation of motoneurons. Here we have investigated the electrophysiological properties of these neurons under the hypothesis that transmission along the extensive neurites requires the aid of voltage-dependent conductances. The results indicate that NS neurons respond to electrical stimulation with a spike-like event, which was not an all-or-none but rather a graded phenomenon that depended on the intensity and duration of the electrical stimulus. The spike-like response was activated at a membrane potential of approximately -50 mV; its amplitude was a logarithmic function of the extracellular Ca 2+ concentration and was unaffected by a broad range of changes in the extracellular Na + concentration; intracellular application of tetraethylammonium (TEA) caused a large increase in its amplitude and duration. These data indicate that NS neurons bear voltage-dependent low-threshold Ca 2+ and TEA-sensitive K + conductances that could contribute to shaping synaptic signals, or transmission along the extensive neuritic tree. © 2008 Springer-Verlag.
author	Rela, Lorena Yang, Sung Min Szczupak, Lidia
author_facet	Rela, Lorena Yang, Sung Min Szczupak, Lidia
author_sort	Rela, Lorena
title	Calcium spikes in a leech nonspiking neuron
title_short	Calcium spikes in a leech nonspiking neuron
title_full	Calcium spikes in a leech nonspiking neuron
title_fullStr	Calcium spikes in a leech nonspiking neuron
title_full_unstemmed	Calcium spikes in a leech nonspiking neuron
title_sort	calcium spikes in a leech nonspiking neuron
publishDate	2009
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03407594_v195_n2_p139_Rela http://hdl.handle.net/20.500.12110/paper_03407594_v195_n2_p139_Rela
work_keys_str_mv	AT relalorena calciumspikesinaleechnonspikingneuron AT yangsungmin calciumspikesinaleechnonspikingneuron AT szczupaklidia calciumspikesinaleechnonspikingneuron
_version_	1768544778348134400

Calcium spikes in a leech nonspiking neuron

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