Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat
Urinary parameters related to acid-base homeostasis were studied in adrenalectomized rats (ADX) as well as in ADX treated with physiological doses of corticosterone (B), aldosterone (aldo) or 18-Hydroxycorticosterone (18HOB) during 1, 3 or 5 days, under basal conditions and after gravage with 200 mM...
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1996
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n3_p149_Igarreta http://hdl.handle.net/20.500.12110/paper_03276309_v46_n3_p149_Igarreta |
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paper:paper_03276309_v46_n3_p149_Igarreta2023-06-08T15:33:27Z Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat 18 hydroxycorticosterone acid-base regulation aldosterone corticosterone metabolic acidosis 18 hydroxycorticosterone aldosterone ammonia corticosterone phosphate acid base balance animal experiment article controlled study drug effect excretion glomerulus filtration intramuscular drug administration male metabolic acidosis nonhuman rat Acid-Base Equilibrium Aldosterone Animals Corticosterone Kidney Male Rats Rats, Sprague-Dawley Urinary parameters related to acid-base homeostasis were studied in adrenalectomized rats (ADX) as well as in ADX treated with physiological doses of corticosterone (B), aldosterone (aldo) or 18-Hydroxycorticosterone (18HOB) during 1, 3 or 5 days, under basal conditions and after gravage with 200 mM HCl. The results showed: a) a persistent effect of B and 18HOB increasing titratable acidity principally in response to acidosis; b) an increased phosphate elimination in acidotic B treated ADX on the first day, and in 18HOB treated ADX on days 3 and 5; c) pronounced increases in blood pH and blood bicarbonate levels provoked by the three steroids on day 1; d) increments of ammonium elimination in response to acidosis by aldo treatment on the first day, while B and 18HOB increase ammonium elimination under almost all conditions during the whole experiment; e) the effects of B and 18HOB would be independent of an increase in sodium retention as well as glomerular filtration rate. 1996 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n3_p149_Igarreta http://hdl.handle.net/20.500.12110/paper_03276309_v46_n3_p149_Igarreta |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
18 hydroxycorticosterone acid-base regulation aldosterone corticosterone metabolic acidosis 18 hydroxycorticosterone aldosterone ammonia corticosterone phosphate acid base balance animal experiment article controlled study drug effect excretion glomerulus filtration intramuscular drug administration male metabolic acidosis nonhuman rat Acid-Base Equilibrium Aldosterone Animals Corticosterone Kidney Male Rats Rats, Sprague-Dawley |
| spellingShingle |
18 hydroxycorticosterone acid-base regulation aldosterone corticosterone metabolic acidosis 18 hydroxycorticosterone aldosterone ammonia corticosterone phosphate acid base balance animal experiment article controlled study drug effect excretion glomerulus filtration intramuscular drug administration male metabolic acidosis nonhuman rat Acid-Base Equilibrium Aldosterone Animals Corticosterone Kidney Male Rats Rats, Sprague-Dawley Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat |
| topic_facet |
18 hydroxycorticosterone acid-base regulation aldosterone corticosterone metabolic acidosis 18 hydroxycorticosterone aldosterone ammonia corticosterone phosphate acid base balance animal experiment article controlled study drug effect excretion glomerulus filtration intramuscular drug administration male metabolic acidosis nonhuman rat Acid-Base Equilibrium Aldosterone Animals Corticosterone Kidney Male Rats Rats, Sprague-Dawley |
| description |
Urinary parameters related to acid-base homeostasis were studied in adrenalectomized rats (ADX) as well as in ADX treated with physiological doses of corticosterone (B), aldosterone (aldo) or 18-Hydroxycorticosterone (18HOB) during 1, 3 or 5 days, under basal conditions and after gravage with 200 mM HCl. The results showed: a) a persistent effect of B and 18HOB increasing titratable acidity principally in response to acidosis; b) an increased phosphate elimination in acidotic B treated ADX on the first day, and in 18HOB treated ADX on days 3 and 5; c) pronounced increases in blood pH and blood bicarbonate levels provoked by the three steroids on day 1; d) increments of ammonium elimination in response to acidosis by aldo treatment on the first day, while B and 18HOB increase ammonium elimination under almost all conditions during the whole experiment; e) the effects of B and 18HOB would be independent of an increase in sodium retention as well as glomerular filtration rate. |
| title |
Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat |
| title_short |
Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat |
| title_full |
Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat |
| title_fullStr |
Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat |
| title_full_unstemmed |
Effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat |
| title_sort |
effects of chronic treatments with adrenal steroids on acid-base homeostasis in the rat |
| publishDate |
1996 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03276309_v46_n3_p149_Igarreta http://hdl.handle.net/20.500.12110/paper_03276309_v46_n3_p149_Igarreta |
| _version_ |
1768541939683033088 |