Virucidal activity presence in Trichilia glabra leaves

Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were in...

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Autores principales:	Cella, Maximiliano, Riva, Diego Ariel, Coulombié, Félix Carlos, Mersich, Susana E.
Publicado:	2004
Materias:	Methanolic extracts Trichilia glabra leaves Virucidal activity chloroform methanol plant extract Trichilia glabra extract unclassified drug antiinflammatory activity antiviral activity article controlled study Herpes simplex virus 1 immunomodulation in vivo study medicinal plant nonhuman plant leaf Poliomyelitis virus Trichilia glabra Vesicular stomatitis virus virus infectivity virus titration Animals Antiviral Agents Cercopithecus aethiops Chemical Fractionation Chloroform Herpesvirus 1, Human Meliaceae Methanol Plant Extracts Plant Leaves Poliovirus Vero Cells Vesicular stomatitis-Indiana virus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v36_n3_p136_Cella http://hdl.handle.net/20.500.12110/paper_03257541_v36_n3_p136_Cella
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03257541_v36_n3_p136_Cella
record_format	dspace
spelling	paper:paper_03257541_v36_n3_p136_Cella2023-06-08T15:32:52Z Virucidal activity presence in Trichilia glabra leaves Cella, Maximiliano Riva, Diego Ariel Coulombié, Félix Carlos Mersich, Susana E. Methanolic extracts Trichilia glabra leaves Virucidal activity chloroform methanol plant extract Trichilia glabra extract unclassified drug antiinflammatory activity antiviral activity article controlled study Herpes simplex virus 1 immunomodulation in vivo study medicinal plant nonhuman plant leaf Poliomyelitis virus Trichilia glabra Vesicular stomatitis virus virus infectivity virus titration Animals Antiviral Agents Cercopithecus aethiops Chemical Fractionation Chloroform Herpesvirus 1, Human Meliaceae Methanol Plant Extracts Plant Leaves Poliovirus Vero Cells Vesicular stomatitis-Indiana virus Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were investigated. Methanolic fraction extracts were active against herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV), while no activity against poliovirus type 3 was observed. VSV was slightly more affected than HSV-1: 2.8 log10 reduction in VSV titer against 2.4 log10 reduction in HSV-1 titer when 0.25 mg/ml F2 fraction was tested and a reduction of 2.7 log10 in VSV virus titer and of 1.5 log10 in HSV-1 virus titer was observed when 0.25 mg/ml F3 fraction was tested. Results obtained in this work suggest a potential pharmaceutical use of TG extract components. Fil:Cella, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Riva, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coulombié, F.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mersich, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v36_n3_p136_Cella http://hdl.handle.net/20.500.12110/paper_03257541_v36_n3_p136_Cella
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Methanolic extracts Trichilia glabra leaves Virucidal activity chloroform methanol plant extract Trichilia glabra extract unclassified drug antiinflammatory activity antiviral activity article controlled study Herpes simplex virus 1 immunomodulation in vivo study medicinal plant nonhuman plant leaf Poliomyelitis virus Trichilia glabra Vesicular stomatitis virus virus infectivity virus titration Animals Antiviral Agents Cercopithecus aethiops Chemical Fractionation Chloroform Herpesvirus 1, Human Meliaceae Methanol Plant Extracts Plant Leaves Poliovirus Vero Cells Vesicular stomatitis-Indiana virus
spellingShingle	Methanolic extracts Trichilia glabra leaves Virucidal activity chloroform methanol plant extract Trichilia glabra extract unclassified drug antiinflammatory activity antiviral activity article controlled study Herpes simplex virus 1 immunomodulation in vivo study medicinal plant nonhuman plant leaf Poliomyelitis virus Trichilia glabra Vesicular stomatitis virus virus infectivity virus titration Animals Antiviral Agents Cercopithecus aethiops Chemical Fractionation Chloroform Herpesvirus 1, Human Meliaceae Methanol Plant Extracts Plant Leaves Poliovirus Vero Cells Vesicular stomatitis-Indiana virus Cella, Maximiliano Riva, Diego Ariel Coulombié, Félix Carlos Mersich, Susana E. Virucidal activity presence in Trichilia glabra leaves
topic_facet	Methanolic extracts Trichilia glabra leaves Virucidal activity chloroform methanol plant extract Trichilia glabra extract unclassified drug antiinflammatory activity antiviral activity article controlled study Herpes simplex virus 1 immunomodulation in vivo study medicinal plant nonhuman plant leaf Poliomyelitis virus Trichilia glabra Vesicular stomatitis virus virus infectivity virus titration Animals Antiviral Agents Cercopithecus aethiops Chemical Fractionation Chloroform Herpesvirus 1, Human Meliaceae Methanol Plant Extracts Plant Leaves Poliovirus Vero Cells Vesicular stomatitis-Indiana virus
description	Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were investigated. Methanolic fraction extracts were active against herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV), while no activity against poliovirus type 3 was observed. VSV was slightly more affected than HSV-1: 2.8 log10 reduction in VSV titer against 2.4 log10 reduction in HSV-1 titer when 0.25 mg/ml F2 fraction was tested and a reduction of 2.7 log10 in VSV virus titer and of 1.5 log10 in HSV-1 virus titer was observed when 0.25 mg/ml F3 fraction was tested. Results obtained in this work suggest a potential pharmaceutical use of TG extract components.
author	Cella, Maximiliano Riva, Diego Ariel Coulombié, Félix Carlos Mersich, Susana E.
author_facet	Cella, Maximiliano Riva, Diego Ariel Coulombié, Félix Carlos Mersich, Susana E.
author_sort	Cella, Maximiliano
title	Virucidal activity presence in Trichilia glabra leaves
title_short	Virucidal activity presence in Trichilia glabra leaves
title_full	Virucidal activity presence in Trichilia glabra leaves
title_fullStr	Virucidal activity presence in Trichilia glabra leaves
title_full_unstemmed	Virucidal activity presence in Trichilia glabra leaves
title_sort	virucidal activity presence in trichilia glabra leaves
publishDate	2004
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v36_n3_p136_Cella http://hdl.handle.net/20.500.12110/paper_03257541_v36_n3_p136_Cella
work_keys_str_mv	AT cellamaximiliano virucidalactivitypresenceintrichiliaglabraleaves AT rivadiegoariel virucidalactivitypresenceintrichiliaglabraleaves AT coulombiefelixcarlos virucidalactivitypresenceintrichiliaglabraleaves AT mersichsusanae virucidalactivitypresenceintrichiliaglabraleaves
_version_	1768544686436253696

Virucidal activity presence in Trichilia glabra leaves

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