Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model

We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. The effective concentrations for 50% inhibition of HSV-1 (F) were 12.5 micrograms/ml for meliacin and 15.7 micrograms/ml for foscarnet, while f...

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Detalles Bibliográficos
Autor principal: Barquero, Andrea Alejandra
Publicado: 1997
Materias:
antivirus agent
foscarnet
meliacin
peptide
vegetable protein
animal
antibiotic resistance
article
cell survival
Cercopithecus
classification
comparative study
drug effect
drug potentiation
Herpes simplex virus
physiology
species difference
Vero cell
virus replication
Animals
Antiviral Agents
Cell Survival
Cercopithecus aethiops
Drug Resistance, Microbial
Drug Synergism
Foscarnet
Peptides
Plant Proteins
Simplexvirus
Species Specificity
Vero Cells
Virus Replication
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v29_n1_p32_Barquero
http://hdl.handle.net/20.500.12110/paper_03257541_v29_n1_p32_Barquero
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_03257541_v29_n1_p32_Barquero
record_format dspace
spelling paper:paper_03257541_v29_n1_p32_Barquero2023-06-08T15:32:42Z Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model Barquero, Andrea Alejandra antivirus agent foscarnet meliacin peptide vegetable protein animal antibiotic resistance article cell survival Cercopithecus classification comparative study drug effect drug potentiation Herpes simplex virus physiology species difference Vero cell virus replication Animals Antiviral Agents Cell Survival Cercopithecus aethiops Drug Resistance, Microbial Drug Synergism Foscarnet Peptides Plant Proteins Simplexvirus Species Specificity Vero Cells Virus Replication We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. The effective concentrations for 50% inhibition of HSV-1 (F) were 12.5 micrograms/ml for meliacin and 15.7 micrograms/ml for foscarnet, while for HSV-1 (B2006) were 3.1 micrograms/ml and 126 micrograms/ml, respectively. The data were analyzed for quantitation of synergism, additivity, and antagonism of multiple drug effect by the three-dimensional model. Some of the meliacin -foscarnet combinations synergistically inhibited HSV-1 (F) and HSV-1 (B2006) replication in vitro at concentrations that did not reduce cellular viability. Fil:Barquero, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v29_n1_p32_Barquero http://hdl.handle.net/20.500.12110/paper_03257541_v29_n1_p32_Barquero
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic antivirus agent
foscarnet
meliacin
peptide
vegetable protein
animal
antibiotic resistance
article
cell survival
Cercopithecus
classification
comparative study
drug effect
drug potentiation
Herpes simplex virus
physiology
species difference
Vero cell
virus replication
Animals
Antiviral Agents
Cell Survival
Cercopithecus aethiops
Drug Resistance, Microbial
Drug Synergism
Foscarnet
Peptides
Plant Proteins
Simplexvirus
Species Specificity
Vero Cells
Virus Replication
spellingShingle antivirus agent
foscarnet
meliacin
peptide
vegetable protein
animal
antibiotic resistance
article
cell survival
Cercopithecus
classification
comparative study
drug effect
drug potentiation
Herpes simplex virus
physiology
species difference
Vero cell
virus replication
Animals
Antiviral Agents
Cell Survival
Cercopithecus aethiops
Drug Resistance, Microbial
Drug Synergism
Foscarnet
Peptides
Plant Proteins
Simplexvirus
Species Specificity
Vero Cells
Virus Replication
Barquero, Andrea Alejandra
Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
topic_facet antivirus agent
foscarnet
meliacin
peptide
vegetable protein
animal
antibiotic resistance
article
cell survival
Cercopithecus
classification
comparative study
drug effect
drug potentiation
Herpes simplex virus
physiology
species difference
Vero cell
virus replication
Animals
Antiviral Agents
Cell Survival
Cercopithecus aethiops
Drug Resistance, Microbial
Drug Synergism
Foscarnet
Peptides
Plant Proteins
Simplexvirus
Species Specificity
Vero Cells
Virus Replication
description We evaluated the in vitro antiviral activity of meliacin combined with foscarnet on the herpes simplex type 1 (HSV-1) strains F and B2006 (tk-) replication. The effective concentrations for 50% inhibition of HSV-1 (F) were 12.5 micrograms/ml for meliacin and 15.7 micrograms/ml for foscarnet, while for HSV-1 (B2006) were 3.1 micrograms/ml and 126 micrograms/ml, respectively. The data were analyzed for quantitation of synergism, additivity, and antagonism of multiple drug effect by the three-dimensional model. Some of the meliacin -foscarnet combinations synergistically inhibited HSV-1 (F) and HSV-1 (B2006) replication in vitro at concentrations that did not reduce cellular viability.
author Barquero, Andrea Alejandra
author_facet Barquero, Andrea Alejandra
author_sort Barquero, Andrea Alejandra
title Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
title_short Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
title_full Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
title_fullStr Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
title_full_unstemmed Combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
title_sort combined activity of meliacin and foscarnet against different strains of herpes simplex virus type 1 using a three-dimensional model
publishDate 1997
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03257541_v29_n1_p32_Barquero
http://hdl.handle.net/20.500.12110/paper_03257541_v29_n1_p32_Barquero
work_keys_str_mv AT barqueroandreaalejandra combinedactivityofmeliacinandfoscarnetagainstdifferentstrainsofherpessimplexvirustype1usingathreedimensionalmodel
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