Chagas disease: The contribution of the center for toxicological research

Chemotherapy of Chagas disease is currently performed by the use of only two drugs: Nifurtimox and Benznidazole. Nifurtimox is a nitrofurane and Benznidazole is a nitroimidazole compound. The use of these drugs to treat the acute phase of the disease is now widely accepted. However, their use in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Castro, José Alberto, Castro, Gerardo Daniel
Publicado:	2015
Materias:	American trypanosomiasis Benznidazole Chagas' disease Chemoprophylaxis Chemotherapy Gentian violet Nifurtimox Gentiana
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v49_n1_p73_Castro http://hdl.handle.net/20.500.12110/paper_03252957_v49_n1_p73_Castro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03252957_v49_n1_p73_Castro
record_format	dspace
spelling	paper:paper_03252957_v49_n1_p73_Castro2023-06-08T15:32:24Z Chagas disease: The contribution of the center for toxicological research Castro, José Alberto Castro, Gerardo Daniel American trypanosomiasis Benznidazole Chagas' disease Chemoprophylaxis Chemotherapy Gentian violet Nifurtimox Gentiana Chemotherapy of Chagas disease is currently performed by the use of only two drugs: Nifurtimox and Benznidazole. Nifurtimox is a nitrofurane and Benznidazole is a nitroimidazole compound. The use of these drugs to treat the acute phase of the disease is now widely accepted. However, their use in the treatment of the chronic phase is not without serious consequences. The side effects of both drugs are a major drawback in their use and often force physicians to stop treatment. In the case of Nifurtimox, experimental toxicity studies showed neurotoxicity, testicular damage, ovarian toxicity and deleterious effects in heart, breast tissue, adrenals, colon and esophagus. Benznidazole deleterious effects were observed in adrenals, colon and esophagus. It also inhibits the metabolism of various xenobiotics transformed by cytochrome P450 and its metabolites react with fetal components in vivo. Both drugs exhibited significant mutagenic effects and in some studies, they demonstrated to be carcinogenic or tumorigenic. Toxic effects of both drugs are dependent on the enzymatic reduction of the nitro group. This paper summarizes this laboratory's activity in an effort to understand the mechanisms of these drugs' toxic action. Fil:Castro, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castro, G.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v49_n1_p73_Castro http://hdl.handle.net/20.500.12110/paper_03252957_v49_n1_p73_Castro
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	American trypanosomiasis Benznidazole Chagas' disease Chemoprophylaxis Chemotherapy Gentian violet Nifurtimox Gentiana
spellingShingle	American trypanosomiasis Benznidazole Chagas' disease Chemoprophylaxis Chemotherapy Gentian violet Nifurtimox Gentiana Castro, José Alberto Castro, Gerardo Daniel Chagas disease: The contribution of the center for toxicological research
topic_facet	American trypanosomiasis Benznidazole Chagas' disease Chemoprophylaxis Chemotherapy Gentian violet Nifurtimox Gentiana
description	Chemotherapy of Chagas disease is currently performed by the use of only two drugs: Nifurtimox and Benznidazole. Nifurtimox is a nitrofurane and Benznidazole is a nitroimidazole compound. The use of these drugs to treat the acute phase of the disease is now widely accepted. However, their use in the treatment of the chronic phase is not without serious consequences. The side effects of both drugs are a major drawback in their use and often force physicians to stop treatment. In the case of Nifurtimox, experimental toxicity studies showed neurotoxicity, testicular damage, ovarian toxicity and deleterious effects in heart, breast tissue, adrenals, colon and esophagus. Benznidazole deleterious effects were observed in adrenals, colon and esophagus. It also inhibits the metabolism of various xenobiotics transformed by cytochrome P450 and its metabolites react with fetal components in vivo. Both drugs exhibited significant mutagenic effects and in some studies, they demonstrated to be carcinogenic or tumorigenic. Toxic effects of both drugs are dependent on the enzymatic reduction of the nitro group. This paper summarizes this laboratory's activity in an effort to understand the mechanisms of these drugs' toxic action.
author	Castro, José Alberto Castro, Gerardo Daniel
author_facet	Castro, José Alberto Castro, Gerardo Daniel
author_sort	Castro, José Alberto
title	Chagas disease: The contribution of the center for toxicological research
title_short	Chagas disease: The contribution of the center for toxicological research
title_full	Chagas disease: The contribution of the center for toxicological research
title_fullStr	Chagas disease: The contribution of the center for toxicological research
title_full_unstemmed	Chagas disease: The contribution of the center for toxicological research
title_sort	chagas disease: the contribution of the center for toxicological research
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v49_n1_p73_Castro http://hdl.handle.net/20.500.12110/paper_03252957_v49_n1_p73_Castro
work_keys_str_mv	AT castrojosealberto chagasdiseasethecontributionofthecenterfortoxicologicalresearch AT castrogerardodaniel chagasdiseasethecontributionofthecenterfortoxicologicalresearch
_version_	1768542364388818944

Chagas disease: The contribution of the center for toxicological research

Ejemplares similares