Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma

Biopsies from human metastatic melanomas were analyzed in order to elucidate the relationship between MCP-1/CCL-2 (monocyte chemoattractant protein-1) chemokine expression by tumor cells, angiogenesis and aggressiveness in tumor development. The chemokine was expressed in 100% of the cases, with het...

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Autor principal: Gazzaniga, Silvina N.
Publicado: 2006
Materias:
Angiogenesis
Macrophages
Melanoma
Monocyte chemoattractant protein-1
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga
http://hdl.handle.net/20.500.12110/paper_03252957_v40_n4_p463_Gazzaniga
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_03252957_v40_n4_p463_Gazzaniga
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spelling paper:paper_03252957_v40_n4_p463_Gazzaniga2023-06-08T15:32:21Z Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma Gazzaniga, Silvina N. Angiogenesis Macrophages Melanoma Monocyte chemoattractant protein-1 Biopsies from human metastatic melanomas were analyzed in order to elucidate the relationship between MCP-1/CCL-2 (monocyte chemoattractant protein-1) chemokine expression by tumor cells, angiogenesis and aggressiveness in tumor development. The chemokine was expressed in 100% of the cases, with heterogeneity in the percentage of positive cells within the tumor mass. Tumors presented an important infiltration of macrophages, particularly associated to areas of active angiogenesis. Microvascular development, assessed by immunohistochemistry, correlated with the high percentage of cells expressing MCP-1/CCL-2. There was also significant correlation with vascularization and mitotic index. These results suggest that vascularization could be predictive of more aggressive melanoma metastasis, where the MCP-1/CCL-2 expression would be closely associated to vessel development through macrophages recruitment. Fil:Gazzaniga, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga http://hdl.handle.net/20.500.12110/paper_03252957_v40_n4_p463_Gazzaniga
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Angiogenesis
Macrophages
Melanoma
Monocyte chemoattractant protein-1
spellingShingle Angiogenesis
Macrophages
Melanoma
Monocyte chemoattractant protein-1
Gazzaniga, Silvina N.
Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
topic_facet Angiogenesis
Macrophages
Melanoma
Monocyte chemoattractant protein-1
description Biopsies from human metastatic melanomas were analyzed in order to elucidate the relationship between MCP-1/CCL-2 (monocyte chemoattractant protein-1) chemokine expression by tumor cells, angiogenesis and aggressiveness in tumor development. The chemokine was expressed in 100% of the cases, with heterogeneity in the percentage of positive cells within the tumor mass. Tumors presented an important infiltration of macrophages, particularly associated to areas of active angiogenesis. Microvascular development, assessed by immunohistochemistry, correlated with the high percentage of cells expressing MCP-1/CCL-2. There was also significant correlation with vascularization and mitotic index. These results suggest that vascularization could be predictive of more aggressive melanoma metastasis, where the MCP-1/CCL-2 expression would be closely associated to vessel development through macrophages recruitment.
author Gazzaniga, Silvina N.
author_facet Gazzaniga, Silvina N.
author_sort Gazzaniga, Silvina N.
title Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
title_short Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
title_full Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
title_fullStr Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
title_full_unstemmed Monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
title_sort monocyte chemoattractant protein correlates with angiogenesis in metastatic melanoma
publishDate 2006
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v40_n4_p463_Gazzaniga
http://hdl.handle.net/20.500.12110/paper_03252957_v40_n4_p463_Gazzaniga
work_keys_str_mv AT gazzanigasilvinan monocytechemoattractantproteincorrelateswithangiogenesisinmetastaticmelanoma
_version_ 1768542504800485376

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