Iron homeostasis. Mechanisms of absorption, uptake and regulation
Iron is an essential nutrient required by every living being. This transition metal is involved in the majority of the metabolic processes, partly because of its ability to reversibly and readily cycle between ferrous (Fe 2+) and ferric (Fe3+) oxidation states. Iron must be transported and stored as...
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2005
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n3_p301_Perez http://hdl.handle.net/20.500.12110/paper_03252957_v39_n3_p301_Perez |
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paper:paper_03252957_v39_n3_p301_Perez2023-06-08T15:32:19Z Iron homeostasis. Mechanisms of absorption, uptake and regulation Pérez, Gladys Mabel Vittori, Daniela Cecilia Pregi, Nicolás Garbosa, Graciela Nesse, Alcira Beatriz Anemia Hemochromatosis Hepcidin Iron Non-transferrin bound iron uptake Transferrin Transferrin receptors Iron is an essential nutrient required by every living being. This transition metal is involved in the majority of the metabolic processes, partly because of its ability to reversibly and readily cycle between ferrous (Fe 2+) and ferric (Fe3+) oxidation states. Iron must be transported and stored as a component of protein complexes. Ferric ions circulate bound to plasma protein transferrin and accumulate within cells in the form of ferritin or hemosiderin. This is due to the fact that iron as a free cation can participate in a number of reactions to produce free radical species, which in turn can severely damage organs. Taking into account that both iron deficiency and iron overload are deleterious, a strict balance between iron absorption and utilization is required. In this work, the distinct pathways of gastrointestinal absorption and cellular uptake of iron are reviewed, giving details of the mechanisms involved in iron homeostasis under different conditions. Condition of iron deficiency and overload are discussed in terms of mechanisms leading to restoration of iron homeostasis. Fil:Pérez, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vittori, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pregi, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Garbossa, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Nesse, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n3_p301_Perez http://hdl.handle.net/20.500.12110/paper_03252957_v39_n3_p301_Perez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Anemia Hemochromatosis Hepcidin Iron Non-transferrin bound iron uptake Transferrin Transferrin receptors |
| spellingShingle |
Anemia Hemochromatosis Hepcidin Iron Non-transferrin bound iron uptake Transferrin Transferrin receptors Pérez, Gladys Mabel Vittori, Daniela Cecilia Pregi, Nicolás Garbosa, Graciela Nesse, Alcira Beatriz Iron homeostasis. Mechanisms of absorption, uptake and regulation |
| topic_facet |
Anemia Hemochromatosis Hepcidin Iron Non-transferrin bound iron uptake Transferrin Transferrin receptors |
| description |
Iron is an essential nutrient required by every living being. This transition metal is involved in the majority of the metabolic processes, partly because of its ability to reversibly and readily cycle between ferrous (Fe 2+) and ferric (Fe3+) oxidation states. Iron must be transported and stored as a component of protein complexes. Ferric ions circulate bound to plasma protein transferrin and accumulate within cells in the form of ferritin or hemosiderin. This is due to the fact that iron as a free cation can participate in a number of reactions to produce free radical species, which in turn can severely damage organs. Taking into account that both iron deficiency and iron overload are deleterious, a strict balance between iron absorption and utilization is required. In this work, the distinct pathways of gastrointestinal absorption and cellular uptake of iron are reviewed, giving details of the mechanisms involved in iron homeostasis under different conditions. Condition of iron deficiency and overload are discussed in terms of mechanisms leading to restoration of iron homeostasis. |
| author |
Pérez, Gladys Mabel Vittori, Daniela Cecilia Pregi, Nicolás Garbosa, Graciela Nesse, Alcira Beatriz |
| author_facet |
Pérez, Gladys Mabel Vittori, Daniela Cecilia Pregi, Nicolás Garbosa, Graciela Nesse, Alcira Beatriz |
| author_sort |
Pérez, Gladys Mabel |
| title |
Iron homeostasis. Mechanisms of absorption, uptake and regulation |
| title_short |
Iron homeostasis. Mechanisms of absorption, uptake and regulation |
| title_full |
Iron homeostasis. Mechanisms of absorption, uptake and regulation |
| title_fullStr |
Iron homeostasis. Mechanisms of absorption, uptake and regulation |
| title_full_unstemmed |
Iron homeostasis. Mechanisms of absorption, uptake and regulation |
| title_sort |
iron homeostasis. mechanisms of absorption, uptake and regulation |
| publishDate |
2005 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v39_n3_p301_Perez http://hdl.handle.net/20.500.12110/paper_03252957_v39_n3_p301_Perez |
| work_keys_str_mv |
AT perezgladysmabel ironhomeostasismechanismsofabsorptionuptakeandregulation AT vittoridanielacecilia ironhomeostasismechanismsofabsorptionuptakeandregulation AT preginicolas ironhomeostasismechanismsofabsorptionuptakeandregulation AT garbosagraciela ironhomeostasismechanismsofabsorptionuptakeandregulation AT nessealcirabeatriz ironhomeostasismechanismsofabsorptionuptakeandregulation |
| _version_ |
1768546397851746304 |