Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood
Maternal immune activation can result in different behavioral abnormalities and brain dysfunction, depending on the nature of the inflammogen and the timing of the challenge. Few studies report the possible link between prenatal exposure to inflammation and mood disorders. Here we aimed to evaluate...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v299_n_p56_Depino http://hdl.handle.net/20.500.12110/paper_03064522_v299_n_p56_Depino |
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paper:paper_03064522_v299_n_p56_Depino2023-06-08T15:31:19Z Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood Depino, Amaicha Mara Maternal immune activation Mood disorders Neurogenesis Reelin Serotonin lipopolysaccharide noradrenalin reelin serotonin sodium chloride nerve cell adhesion molecule nerve protein noradrenalin reelin protein scleroprotein serine proteinase serotonin adult adulthood animal cell animal experiment animal model animal tissue anxiety Article bacterial infection behavior disorder brain function controlled study dentate gyrus depression disease association elevated plus maze test female forced swim test gestation period hippocampus immunoreactivity inflammation male maternal disease molecular pathology mouse nervous system development nonhuman open field behavior prenatal exposure priority journal progeny tail suspension test animal anxiety C57BL mouse chemically induced chemistry complication depression drug effects inflammation metabolism motor activity pathophysiology pregnancy prenatal exposure psychology Animals Anxiety Cell Adhesion Molecules, Neuronal Depression Extracellular Matrix Proteins Female Hippocampus Inflammation Lipopolysaccharides Male Mice Mice, Inbred C57BL Motor Activity Nerve Tissue Proteins Norepinephrine Pregnancy Prenatal Exposure Delayed Effects Serine Endopeptidases Serotonin Maternal immune activation can result in different behavioral abnormalities and brain dysfunction, depending on the nature of the inflammogen and the timing of the challenge. Few studies report the possible link between prenatal exposure to inflammation and mood disorders. Here we aimed to evaluate the effects of a single low lipopolysaccharide (LPS) injection to the dam at gestational day 9 on the offspring behavior and hippocampal function. We found that mice exposed to LPS show anxiety- and depression-related behaviors. Specifically, we found that animals prenatally exposed to LPS avoided the open arms of an elevated plus maze, the center of an open field and the lit side of a light/dark box, and they spent more time immobile in both the forced swimming and tail suspension tests, when compared with offspring of saline-injected dams. In addition, LPS mice had reduced serotonin and noradrenaline levels in the hippocampus and diminished Reelin immunoreactivity in the dentate gyrus, while their adult hippocampal neurogenesis was not affected. Results presented here support specific long-term effects of the response to a bacterial immunogen early in pregnancy, as opposed to different effects previously reported of viral immunogens and/or responses in late pregnancy. Our work adds to recent reports and stresses the relevance of considering prenatal exposure to a maternal immune response as a risk factor for mood disorders. © 2015 IBRO. Fil:Depino, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v299_n_p56_Depino http://hdl.handle.net/20.500.12110/paper_03064522_v299_n_p56_Depino |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Maternal immune activation Mood disorders Neurogenesis Reelin Serotonin lipopolysaccharide noradrenalin reelin serotonin sodium chloride nerve cell adhesion molecule nerve protein noradrenalin reelin protein scleroprotein serine proteinase serotonin adult adulthood animal cell animal experiment animal model animal tissue anxiety Article bacterial infection behavior disorder brain function controlled study dentate gyrus depression disease association elevated plus maze test female forced swim test gestation period hippocampus immunoreactivity inflammation male maternal disease molecular pathology mouse nervous system development nonhuman open field behavior prenatal exposure priority journal progeny tail suspension test animal anxiety C57BL mouse chemically induced chemistry complication depression drug effects inflammation metabolism motor activity pathophysiology pregnancy prenatal exposure psychology Animals Anxiety Cell Adhesion Molecules, Neuronal Depression Extracellular Matrix Proteins Female Hippocampus Inflammation Lipopolysaccharides Male Mice Mice, Inbred C57BL Motor Activity Nerve Tissue Proteins Norepinephrine Pregnancy Prenatal Exposure Delayed Effects Serine Endopeptidases Serotonin |
| spellingShingle |
Maternal immune activation Mood disorders Neurogenesis Reelin Serotonin lipopolysaccharide noradrenalin reelin serotonin sodium chloride nerve cell adhesion molecule nerve protein noradrenalin reelin protein scleroprotein serine proteinase serotonin adult adulthood animal cell animal experiment animal model animal tissue anxiety Article bacterial infection behavior disorder brain function controlled study dentate gyrus depression disease association elevated plus maze test female forced swim test gestation period hippocampus immunoreactivity inflammation male maternal disease molecular pathology mouse nervous system development nonhuman open field behavior prenatal exposure priority journal progeny tail suspension test animal anxiety C57BL mouse chemically induced chemistry complication depression drug effects inflammation metabolism motor activity pathophysiology pregnancy prenatal exposure psychology Animals Anxiety Cell Adhesion Molecules, Neuronal Depression Extracellular Matrix Proteins Female Hippocampus Inflammation Lipopolysaccharides Male Mice Mice, Inbred C57BL Motor Activity Nerve Tissue Proteins Norepinephrine Pregnancy Prenatal Exposure Delayed Effects Serine Endopeptidases Serotonin Depino, Amaicha Mara Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood |
| topic_facet |
Maternal immune activation Mood disorders Neurogenesis Reelin Serotonin lipopolysaccharide noradrenalin reelin serotonin sodium chloride nerve cell adhesion molecule nerve protein noradrenalin reelin protein scleroprotein serine proteinase serotonin adult adulthood animal cell animal experiment animal model animal tissue anxiety Article bacterial infection behavior disorder brain function controlled study dentate gyrus depression disease association elevated plus maze test female forced swim test gestation period hippocampus immunoreactivity inflammation male maternal disease molecular pathology mouse nervous system development nonhuman open field behavior prenatal exposure priority journal progeny tail suspension test animal anxiety C57BL mouse chemically induced chemistry complication depression drug effects inflammation metabolism motor activity pathophysiology pregnancy prenatal exposure psychology Animals Anxiety Cell Adhesion Molecules, Neuronal Depression Extracellular Matrix Proteins Female Hippocampus Inflammation Lipopolysaccharides Male Mice Mice, Inbred C57BL Motor Activity Nerve Tissue Proteins Norepinephrine Pregnancy Prenatal Exposure Delayed Effects Serine Endopeptidases Serotonin |
| description |
Maternal immune activation can result in different behavioral abnormalities and brain dysfunction, depending on the nature of the inflammogen and the timing of the challenge. Few studies report the possible link between prenatal exposure to inflammation and mood disorders. Here we aimed to evaluate the effects of a single low lipopolysaccharide (LPS) injection to the dam at gestational day 9 on the offspring behavior and hippocampal function. We found that mice exposed to LPS show anxiety- and depression-related behaviors. Specifically, we found that animals prenatally exposed to LPS avoided the open arms of an elevated plus maze, the center of an open field and the lit side of a light/dark box, and they spent more time immobile in both the forced swimming and tail suspension tests, when compared with offspring of saline-injected dams. In addition, LPS mice had reduced serotonin and noradrenaline levels in the hippocampus and diminished Reelin immunoreactivity in the dentate gyrus, while their adult hippocampal neurogenesis was not affected. Results presented here support specific long-term effects of the response to a bacterial immunogen early in pregnancy, as opposed to different effects previously reported of viral immunogens and/or responses in late pregnancy. Our work adds to recent reports and stresses the relevance of considering prenatal exposure to a maternal immune response as a risk factor for mood disorders. © 2015 IBRO. |
| author |
Depino, Amaicha Mara |
| author_facet |
Depino, Amaicha Mara |
| author_sort |
Depino, Amaicha Mara |
| title |
Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood |
| title_short |
Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood |
| title_full |
Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood |
| title_fullStr |
Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood |
| title_full_unstemmed |
Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood |
| title_sort |
early prenatal exposure to lps results in anxiety- and depression-related behaviors in adulthood |
| publishDate |
2015 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v299_n_p56_Depino http://hdl.handle.net/20.500.12110/paper_03064522_v299_n_p56_Depino |
| work_keys_str_mv |
AT depinoamaichamara earlyprenatalexposuretolpsresultsinanxietyanddepressionrelatedbehaviorsinadulthood |
| _version_ |
1768541611027857408 |