Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation
Reconsolidation has been defined as the process of memory stabilization after retrieval involving, among others, gene expression regulation and post-translational modifications. Many of these mechanisms are shared with memory consolidation. Here, we studied hippocampal ERK participation on memory re...
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v294_n_p227_Krawczyk http://hdl.handle.net/20.500.12110/paper_03064522_v294_n_p227_Krawczyk |
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paper:paper_03064522_v294_n_p227_Krawczyk2023-06-08T15:31:19Z Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation Romano, Arturo Gabriel Feld, Mariana ERK Inhibitory avoidance MAPK Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase 1 animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme inhibition footshock hippocampus inhibition kinetics male memory consolidation mental task mouse neuromodulation nonhuman priority journal task performance animal avoidance behavior memory metabolism phosphorylation physiology protein processing signal transduction Animals Avoidance Learning Hippocampus Male MAP Kinase Signaling System Memory Mice Mitogen-Activated Protein Kinase 1 Phosphorylation Protein Processing, Post-Translational Reconsolidation has been defined as the process of memory stabilization after retrieval involving, among others, gene expression regulation and post-translational modifications. Many of these mechanisms are shared with memory consolidation. Here, we studied hippocampal ERK participation on memory reconsolidation of an inhibitory avoidance task in CF-1 mice. We found a retrieval-induced cytosolic ERK2 activation in the hippocampus (HIP) 15. min after memory reactivation, and an inhibition at 45. min. PD098059, a MEK1/2 (MAPK/ERK kinase) inhibitor, administered in the HIP immediately after retrieval impaired memory in a dose-dependent fashion. However, infusions of the highest dose of PD098059 performed 40. min after retrieval enhanced memory in mice trained with a weaker footshock. These results suggest for the first time that ERK2 is involved in memory reconsolidation in a biphasic fashion. Furthermore, the inhibition of ERK could either impair or enhance mice performance depending on ERK state of activation. © 2015 IBRO. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Feld, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v294_n_p227_Krawczyk http://hdl.handle.net/20.500.12110/paper_03064522_v294_n_p227_Krawczyk |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
ERK Inhibitory avoidance MAPK Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase 1 animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme inhibition footshock hippocampus inhibition kinetics male memory consolidation mental task mouse neuromodulation nonhuman priority journal task performance animal avoidance behavior memory metabolism phosphorylation physiology protein processing signal transduction Animals Avoidance Learning Hippocampus Male MAP Kinase Signaling System Memory Mice Mitogen-Activated Protein Kinase 1 Phosphorylation Protein Processing, Post-Translational |
spellingShingle |
ERK Inhibitory avoidance MAPK Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase 1 animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme inhibition footshock hippocampus inhibition kinetics male memory consolidation mental task mouse neuromodulation nonhuman priority journal task performance animal avoidance behavior memory metabolism phosphorylation physiology protein processing signal transduction Animals Avoidance Learning Hippocampus Male MAP Kinase Signaling System Memory Mice Mitogen-Activated Protein Kinase 1 Phosphorylation Protein Processing, Post-Translational Romano, Arturo Gabriel Feld, Mariana Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
topic_facet |
ERK Inhibitory avoidance MAPK Memory reconsolidation Mice PD098059 2 (2 amino 3 methoxyphenyl)chromone mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase 1 animal behavior animal experiment animal tissue Article avoidance behavior controlled study enzyme activation enzyme inhibition footshock hippocampus inhibition kinetics male memory consolidation mental task mouse neuromodulation nonhuman priority journal task performance animal avoidance behavior memory metabolism phosphorylation physiology protein processing signal transduction Animals Avoidance Learning Hippocampus Male MAP Kinase Signaling System Memory Mice Mitogen-Activated Protein Kinase 1 Phosphorylation Protein Processing, Post-Translational |
description |
Reconsolidation has been defined as the process of memory stabilization after retrieval involving, among others, gene expression regulation and post-translational modifications. Many of these mechanisms are shared with memory consolidation. Here, we studied hippocampal ERK participation on memory reconsolidation of an inhibitory avoidance task in CF-1 mice. We found a retrieval-induced cytosolic ERK2 activation in the hippocampus (HIP) 15. min after memory reactivation, and an inhibition at 45. min. PD098059, a MEK1/2 (MAPK/ERK kinase) inhibitor, administered in the HIP immediately after retrieval impaired memory in a dose-dependent fashion. However, infusions of the highest dose of PD098059 performed 40. min after retrieval enhanced memory in mice trained with a weaker footshock. These results suggest for the first time that ERK2 is involved in memory reconsolidation in a biphasic fashion. Furthermore, the inhibition of ERK could either impair or enhance mice performance depending on ERK state of activation. © 2015 IBRO. |
author |
Romano, Arturo Gabriel Feld, Mariana |
author_facet |
Romano, Arturo Gabriel Feld, Mariana |
author_sort |
Romano, Arturo Gabriel |
title |
Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
title_short |
Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
title_full |
Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
title_fullStr |
Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
title_full_unstemmed |
Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation |
title_sort |
memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic erk2 bidirectional modulation |
publishDate |
2015 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v294_n_p227_Krawczyk http://hdl.handle.net/20.500.12110/paper_03064522_v294_n_p227_Krawczyk |
work_keys_str_mv |
AT romanoarturogabriel memoryreconsolidationofaninhibitoryavoidancetaskinmiceinvolvescytosolicerk2bidirectionalmodulation AT feldmariana memoryreconsolidationofaninhibitoryavoidancetaskinmiceinvolvescytosolicerk2bidirectionalmodulation |
_version_ |
1768546493231267840 |