Reconsolidation involves histone acetylation depending on the strength of the memory
Gene expression is a necessary step for memory re-stabilization after retrieval, a process known as reconsolidation. Histone acetylation is a fundamental mechanism involved in epigenetic regulation of gene expression and has been implicated in memory consolidation. However, few studies are available...
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2012
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v219_n_p145_Federman http://hdl.handle.net/20.500.12110/paper_03064522_v219_n_p145_Federman |
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paper:paper_03064522_v219_n_p145_Federman2023-06-08T15:31:17Z Reconsolidation involves histone acetylation depending on the strength of the memory Federman, Maria Noel Fustiñana, Maria Sol Romano, Arturo Gabriel HAT inhibitor HDAC inhibitor Histone acetylation Long-term memory Reconsolidation butyric acid histone deacetylase histone H3 animal experiment animal tissue article brain tissue Chasmagnathus granulatus context signal memory controlled study crab enzyme inhibition histone acetylation long term memory male memory memory consolidation memory reconsolidation nonhuman priority journal reinforcement short term memory Acetylation Animals Brachyura Histones Male Memory Gene expression is a necessary step for memory re-stabilization after retrieval, a process known as reconsolidation. Histone acetylation is a fundamental mechanism involved in epigenetic regulation of gene expression and has been implicated in memory consolidation. However, few studies are available in reconsolidation, all of them in vertebrate models. Additionally, the recruitment of histone acetylation as a function of different memory strengths has not been systematically analyzed before. Here we studied the role of histone acetylation in reconsolidation using a well-characterized memory model in invertebrate, the context-signal memory in the crab Chasmagnathus. Firstly, we found an increase in histone H3 acetylation 1. h after memory reactivation returning to basal levels at 3. h. Strikingly, this increment was only detected during reconsolidation of a long-term memory induced by a strong training of 30 trials, but not for a short-term memory formed by a weak training of five trials or for a long-term memory induced by a standard training of 15 trials. Furthermore, we showed that a weak memory which was enhanced during consolidation by histone deacetylases inhibition, also recruited histone H3 acetylation in reconsolidation as the strong training does. Accordingly, we found the first evidence that the administration of a histone acetyl transferase inhibitor during memory reconsolidation impairs long-term memory re-stabilization. Finally, we found that strong training memory, at variance with the standard training memory, was resistant to extinction, indicating that such strong training induced in fact a stronger memory. In conclusion, the results presented here support that the participation of histone acetylation during reconsolidation is an evolutionary conserved feature and constitutes a specific molecular characteristic of strong memories. © 2012 IBRO. Fil:Federman, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fustiñana, M.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v219_n_p145_Federman http://hdl.handle.net/20.500.12110/paper_03064522_v219_n_p145_Federman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
HAT inhibitor HDAC inhibitor Histone acetylation Long-term memory Reconsolidation butyric acid histone deacetylase histone H3 animal experiment animal tissue article brain tissue Chasmagnathus granulatus context signal memory controlled study crab enzyme inhibition histone acetylation long term memory male memory memory consolidation memory reconsolidation nonhuman priority journal reinforcement short term memory Acetylation Animals Brachyura Histones Male Memory |
| spellingShingle |
HAT inhibitor HDAC inhibitor Histone acetylation Long-term memory Reconsolidation butyric acid histone deacetylase histone H3 animal experiment animal tissue article brain tissue Chasmagnathus granulatus context signal memory controlled study crab enzyme inhibition histone acetylation long term memory male memory memory consolidation memory reconsolidation nonhuman priority journal reinforcement short term memory Acetylation Animals Brachyura Histones Male Memory Federman, Maria Noel Fustiñana, Maria Sol Romano, Arturo Gabriel Reconsolidation involves histone acetylation depending on the strength of the memory |
| topic_facet |
HAT inhibitor HDAC inhibitor Histone acetylation Long-term memory Reconsolidation butyric acid histone deacetylase histone H3 animal experiment animal tissue article brain tissue Chasmagnathus granulatus context signal memory controlled study crab enzyme inhibition histone acetylation long term memory male memory memory consolidation memory reconsolidation nonhuman priority journal reinforcement short term memory Acetylation Animals Brachyura Histones Male Memory |
| description |
Gene expression is a necessary step for memory re-stabilization after retrieval, a process known as reconsolidation. Histone acetylation is a fundamental mechanism involved in epigenetic regulation of gene expression and has been implicated in memory consolidation. However, few studies are available in reconsolidation, all of them in vertebrate models. Additionally, the recruitment of histone acetylation as a function of different memory strengths has not been systematically analyzed before. Here we studied the role of histone acetylation in reconsolidation using a well-characterized memory model in invertebrate, the context-signal memory in the crab Chasmagnathus. Firstly, we found an increase in histone H3 acetylation 1. h after memory reactivation returning to basal levels at 3. h. Strikingly, this increment was only detected during reconsolidation of a long-term memory induced by a strong training of 30 trials, but not for a short-term memory formed by a weak training of five trials or for a long-term memory induced by a standard training of 15 trials. Furthermore, we showed that a weak memory which was enhanced during consolidation by histone deacetylases inhibition, also recruited histone H3 acetylation in reconsolidation as the strong training does. Accordingly, we found the first evidence that the administration of a histone acetyl transferase inhibitor during memory reconsolidation impairs long-term memory re-stabilization. Finally, we found that strong training memory, at variance with the standard training memory, was resistant to extinction, indicating that such strong training induced in fact a stronger memory. In conclusion, the results presented here support that the participation of histone acetylation during reconsolidation is an evolutionary conserved feature and constitutes a specific molecular characteristic of strong memories. © 2012 IBRO. |
| author |
Federman, Maria Noel Fustiñana, Maria Sol Romano, Arturo Gabriel |
| author_facet |
Federman, Maria Noel Fustiñana, Maria Sol Romano, Arturo Gabriel |
| author_sort |
Federman, Maria Noel |
| title |
Reconsolidation involves histone acetylation depending on the strength of the memory |
| title_short |
Reconsolidation involves histone acetylation depending on the strength of the memory |
| title_full |
Reconsolidation involves histone acetylation depending on the strength of the memory |
| title_fullStr |
Reconsolidation involves histone acetylation depending on the strength of the memory |
| title_full_unstemmed |
Reconsolidation involves histone acetylation depending on the strength of the memory |
| title_sort |
reconsolidation involves histone acetylation depending on the strength of the memory |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v219_n_p145_Federman http://hdl.handle.net/20.500.12110/paper_03064522_v219_n_p145_Federman |
| work_keys_str_mv |
AT federmanmarianoel reconsolidationinvolveshistoneacetylationdependingonthestrengthofthememory AT fustinanamariasol reconsolidationinvolveshistoneacetylationdependingonthestrengthofthememory AT romanoarturogabriel reconsolidationinvolveshistoneacetylationdependingonthestrengthofthememory |
| _version_ |
1768543609738493952 |