Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus

Long-term memory formation depends on protein and mRNA synthesis that subserves synaptic reorganization. The removal of pre-existing inhibitory proteins by the ubiquitin-proteasome system (UPS) is proposed as a crucial step to support these modifications. The activation of the constitutive transcrip...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Merlo, Emiliano, Romano, Arturo Gabriel
Publicado:	2007
Materias:	consolidation long-term memory MG132 NF-κB transcription factor ubiquitin-proteasome system benzyloxycarbonylleucylleucylleucinal I kappa B immunoglobulin enhancer binding protein proteasome ubiquitin animal experiment article controlled study crab drug effect drug inhibition long term memory male nonhuman priority journal short term memory Animals Brachyura Conditioning, Classical Cysteine Proteinase Inhibitors Dose-Response Relationship, Drug Leupeptins Male Memory Motor Activity Neuronal Plasticity NF-kappa B Proteasome Endopeptidase Complex Time Factors Ubiquitin
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v147_n1_p46_Merlo http://hdl.handle.net/20.500.12110/paper_03064522_v147_n1_p46_Merlo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03064522_v147_n1_p46_Merlo
record_format	dspace
spelling	paper:paper_03064522_v147_n1_p46_Merlo2023-06-08T15:31:14Z Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus Merlo, Emiliano Romano, Arturo Gabriel consolidation long-term memory MG132 NF-κB transcription factor ubiquitin-proteasome system benzyloxycarbonylleucylleucylleucinal I kappa B immunoglobulin enhancer binding protein proteasome ubiquitin animal experiment article controlled study crab drug effect drug inhibition long term memory male nonhuman priority journal short term memory Animals Brachyura Conditioning, Classical Cysteine Proteinase Inhibitors Dose-Response Relationship, Drug Leupeptins Male Memory Motor Activity Neuronal Plasticity NF-kappa B Proteasome Endopeptidase Complex Time Factors Ubiquitin Long-term memory formation depends on protein and mRNA synthesis that subserves synaptic reorganization. The removal of pre-existing inhibitory proteins by the ubiquitin-proteasome system (UPS) is proposed as a crucial step to support these modifications. The activation of the constitutive transcription factor nuclear factor κB (NF-κB) depends on the degradation of the inhibitor of NF-κB (IκB) by the UPS. Here we study the effect of a UPS inhibitor, MG132, on long-term memory consolidation and NF-κB activation in the learning paradigm of the crab Chasmagnathus, a model in which this transcription factor plays a key role. Here we found that administration of MG132 interferes with long-term memory but not with short-term memory, and no facilitatory effects were found. Then we studied the effect of the UPS inhibitor on NF-κB pathway, finding that MG132 blocks the activation of NF-κB induced by training. These results suggest that the UPS is necessary for long-term memory consolidation, allowing for the activation of NF-κB as one of the target molecular pathways. © 2007 IBRO. Fil:Merlo, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v147_n1_p46_Merlo http://hdl.handle.net/20.500.12110/paper_03064522_v147_n1_p46_Merlo
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	consolidation long-term memory MG132 NF-κB transcription factor ubiquitin-proteasome system benzyloxycarbonylleucylleucylleucinal I kappa B immunoglobulin enhancer binding protein proteasome ubiquitin animal experiment article controlled study crab drug effect drug inhibition long term memory male nonhuman priority journal short term memory Animals Brachyura Conditioning, Classical Cysteine Proteinase Inhibitors Dose-Response Relationship, Drug Leupeptins Male Memory Motor Activity Neuronal Plasticity NF-kappa B Proteasome Endopeptidase Complex Time Factors Ubiquitin
spellingShingle	consolidation long-term memory MG132 NF-κB transcription factor ubiquitin-proteasome system benzyloxycarbonylleucylleucylleucinal I kappa B immunoglobulin enhancer binding protein proteasome ubiquitin animal experiment article controlled study crab drug effect drug inhibition long term memory male nonhuman priority journal short term memory Animals Brachyura Conditioning, Classical Cysteine Proteinase Inhibitors Dose-Response Relationship, Drug Leupeptins Male Memory Motor Activity Neuronal Plasticity NF-kappa B Proteasome Endopeptidase Complex Time Factors Ubiquitin Merlo, Emiliano Romano, Arturo Gabriel Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus
topic_facet	consolidation long-term memory MG132 NF-κB transcription factor ubiquitin-proteasome system benzyloxycarbonylleucylleucylleucinal I kappa B immunoglobulin enhancer binding protein proteasome ubiquitin animal experiment article controlled study crab drug effect drug inhibition long term memory male nonhuman priority journal short term memory Animals Brachyura Conditioning, Classical Cysteine Proteinase Inhibitors Dose-Response Relationship, Drug Leupeptins Male Memory Motor Activity Neuronal Plasticity NF-kappa B Proteasome Endopeptidase Complex Time Factors Ubiquitin
description	Long-term memory formation depends on protein and mRNA synthesis that subserves synaptic reorganization. The removal of pre-existing inhibitory proteins by the ubiquitin-proteasome system (UPS) is proposed as a crucial step to support these modifications. The activation of the constitutive transcription factor nuclear factor κB (NF-κB) depends on the degradation of the inhibitor of NF-κB (IκB) by the UPS. Here we study the effect of a UPS inhibitor, MG132, on long-term memory consolidation and NF-κB activation in the learning paradigm of the crab Chasmagnathus, a model in which this transcription factor plays a key role. Here we found that administration of MG132 interferes with long-term memory but not with short-term memory, and no facilitatory effects were found. Then we studied the effect of the UPS inhibitor on NF-κB pathway, finding that MG132 blocks the activation of NF-κB induced by training. These results suggest that the UPS is necessary for long-term memory consolidation, allowing for the activation of NF-κB as one of the target molecular pathways. © 2007 IBRO.
author	Merlo, Emiliano Romano, Arturo Gabriel
author_facet	Merlo, Emiliano Romano, Arturo Gabriel
author_sort	Merlo, Emiliano
title	Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus
title_short	Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus
title_full	Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus
title_fullStr	Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus
title_full_unstemmed	Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus
title_sort	long-term memory consolidation depends on proteasome activity in the crab chasmagnathus
publishDate	2007
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v147_n1_p46_Merlo http://hdl.handle.net/20.500.12110/paper_03064522_v147_n1_p46_Merlo
work_keys_str_mv	AT merloemiliano longtermmemoryconsolidationdependsonproteasomeactivityinthecrabchasmagnathus AT romanoarturogabriel longtermmemoryconsolidationdependsonproteasomeactivityinthecrabchasmagnathus
_version_	1768542739072286720

Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus

Ejemplares similares