Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo
1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. in vitro and in vivo studies revealed that CP induced but did not activate (5-aminolaevulinic acid (ALA) synthase....
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1992
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paper:paper_03064492_v102_n1_p143_Cochon2023-06-08T15:31:09Z Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo Cochón, Adriana Cristina 5 aminolevulinate synthase acrolein cyclophosphamide cytochrome p450 drug metabolite phenobarbital porphyrin proadifen 5 aminolevulinate synthase acrolein allylisopropylacetamide cyclophosphamide cytochrome P450 phenobarbital porphyrin animal experiment article chick embryo controlled study embryo enzyme induction nonhuman priority journal animal biosynthesis chemical structure chemistry chick embryo drug effect enzyme induction enzymology gestational age liver metabolism 5-Aminolevulinate Synthetase Acrolein Allylisopropylacetamide Animals Chick Embryo Cyclophosphamide Cytochrome P-450 Enzyme System Enzyme Induction Gestational Age Liver Molecular Structure Phenobarbital Porphyrins Proadifen 1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. in vitro and in vivo studies revealed that CP induced but did not activate (5-aminolaevulinic acid (ALA) synthase. 3. Pretreatments with phenobarbital (PB) or SKF-525A did not modify ALA-synthase induction produced by CP. 4. Acrolein administration neither induced ALA-synthase activity nor increased cytochrome P-450 content or led to hepatic porphyrin accumulation. 5. Time course induction of cytochrome P-450 content after administration of CP or PB was similar. 6. The results obtained would indicate that CP is a strong inducer of both ALA-synthase activity and microsomal cytochrome P-450 content in liver of 17 day-old chick embryos and that its porphyrinogenic activity is not mediated by its metabolite acrolein. © 1992. Fil:Cochón, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1992 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064492_v102_n1_p143_Cochon http://hdl.handle.net/20.500.12110/paper_03064492_v102_n1_p143_Cochon |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
5 aminolevulinate synthase acrolein cyclophosphamide cytochrome p450 drug metabolite phenobarbital porphyrin proadifen 5 aminolevulinate synthase acrolein allylisopropylacetamide cyclophosphamide cytochrome P450 phenobarbital porphyrin animal experiment article chick embryo controlled study embryo enzyme induction nonhuman priority journal animal biosynthesis chemical structure chemistry chick embryo drug effect enzyme induction enzymology gestational age liver metabolism 5-Aminolevulinate Synthetase Acrolein Allylisopropylacetamide Animals Chick Embryo Cyclophosphamide Cytochrome P-450 Enzyme System Enzyme Induction Gestational Age Liver Molecular Structure Phenobarbital Porphyrins Proadifen |
| spellingShingle |
5 aminolevulinate synthase acrolein cyclophosphamide cytochrome p450 drug metabolite phenobarbital porphyrin proadifen 5 aminolevulinate synthase acrolein allylisopropylacetamide cyclophosphamide cytochrome P450 phenobarbital porphyrin animal experiment article chick embryo controlled study embryo enzyme induction nonhuman priority journal animal biosynthesis chemical structure chemistry chick embryo drug effect enzyme induction enzymology gestational age liver metabolism 5-Aminolevulinate Synthetase Acrolein Allylisopropylacetamide Animals Chick Embryo Cyclophosphamide Cytochrome P-450 Enzyme System Enzyme Induction Gestational Age Liver Molecular Structure Phenobarbital Porphyrins Proadifen Cochón, Adriana Cristina Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo |
| topic_facet |
5 aminolevulinate synthase acrolein cyclophosphamide cytochrome p450 drug metabolite phenobarbital porphyrin proadifen 5 aminolevulinate synthase acrolein allylisopropylacetamide cyclophosphamide cytochrome P450 phenobarbital porphyrin animal experiment article chick embryo controlled study embryo enzyme induction nonhuman priority journal animal biosynthesis chemical structure chemistry chick embryo drug effect enzyme induction enzymology gestational age liver metabolism 5-Aminolevulinate Synthetase Acrolein Allylisopropylacetamide Animals Chick Embryo Cyclophosphamide Cytochrome P-450 Enzyme System Enzyme Induction Gestational Age Liver Molecular Structure Phenobarbital Porphyrins Proadifen |
| description |
1. Some studies of cyclophosphamide (CP) and its metabolite acrolein in chick embryo liver were carried out in order to investigate the mechanism of the porphyrinogenic action of CP. 2. in vitro and in vivo studies revealed that CP induced but did not activate (5-aminolaevulinic acid (ALA) synthase. 3. Pretreatments with phenobarbital (PB) or SKF-525A did not modify ALA-synthase induction produced by CP. 4. Acrolein administration neither induced ALA-synthase activity nor increased cytochrome P-450 content or led to hepatic porphyrin accumulation. 5. Time course induction of cytochrome P-450 content after administration of CP or PB was similar. 6. The results obtained would indicate that CP is a strong inducer of both ALA-synthase activity and microsomal cytochrome P-450 content in liver of 17 day-old chick embryos and that its porphyrinogenic activity is not mediated by its metabolite acrolein. © 1992. |
| author |
Cochón, Adriana Cristina |
| author_facet |
Cochón, Adriana Cristina |
| author_sort |
Cochón, Adriana Cristina |
| title |
Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo |
| title_short |
Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo |
| title_full |
Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo |
| title_fullStr |
Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo |
| title_full_unstemmed |
Cyclophosphamide and its metabolite acrolein. Some studies on their porphyrinogenic action in 17 day old chick embryo |
| title_sort |
cyclophosphamide and its metabolite acrolein. some studies on their porphyrinogenic action in 17 day old chick embryo |
| publishDate |
1992 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064492_v102_n1_p143_Cochon http://hdl.handle.net/20.500.12110/paper_03064492_v102_n1_p143_Cochon |
| work_keys_str_mv |
AT cochonadrianacristina cyclophosphamideanditsmetaboliteacroleinsomestudiesontheirporphyrinogenicactionin17dayoldchickembryo |
| _version_ |
1768542692304748544 |