Griseofulvin-induced hepatopathy due to abnormalities in heme pathways
1. The effect of long term griseofulvin (GRIS) topical administration on some indica tors of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porphyrin crystals were observed under light microscopy, 3. An earlier onset of hepatopathy was established (3-fold) in...
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1997
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v29_n2_p207_Polo http://hdl.handle.net/20.500.12110/paper_03063623_v29_n2_p207_Polo |
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paper:paper_03063623_v29_n2_p207_Polo2023-06-08T15:31:08Z Griseofulvin-induced hepatopathy due to abnormalities in heme pathways Buzaleh, Ana María Vázquez, Elba Susana Afonso, Susana Graciela Batlle, Alcira María del Carmen Cholestasis Griseofulvan Heme pathway Hepatopathy alkaline phosphatase aspartate aminotransferase bilirubin bilirubin glucuronide griseofulvin heme porphyrin xenobiotic agent animal experiment animal tissue article cholestasis controlled study liver disease liver injury liver level long term exposure male microscopy mouse nonhuman priority journal topical drug administration Administration, Topical Animals Antibiotics, Antifungal Biological Markers Griseofulvin Heme Liver Liver Function Tests Male Mice 1. The effect of long term griseofulvin (GRIS) topical administration on some indica tors of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porphyrin crystals were observed under light microscopy, 3. An earlier onset of hepatopathy was established (3-fold) increase of direct bilirubin values after 7 days of treatment; hepatic injury was confirmed by measuring a g fold increase of free bilirubin. 4. Enhanced values of alkaline phosphatase and glutamic oxalacetic transaminase (GOT) confirmed the onset of cholestasis. 5. Topical application of GRIS induced measurable hepatopathy. Nevertheless, we cannot discard the possibility that this hepatopathy could also be attributed in part to a direct reaction to xenobiotics. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Carmen Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v29_n2_p207_Polo http://hdl.handle.net/20.500.12110/paper_03063623_v29_n2_p207_Polo |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Cholestasis Griseofulvan Heme pathway Hepatopathy alkaline phosphatase aspartate aminotransferase bilirubin bilirubin glucuronide griseofulvin heme porphyrin xenobiotic agent animal experiment animal tissue article cholestasis controlled study liver disease liver injury liver level long term exposure male microscopy mouse nonhuman priority journal topical drug administration Administration, Topical Animals Antibiotics, Antifungal Biological Markers Griseofulvin Heme Liver Liver Function Tests Male Mice |
spellingShingle |
Cholestasis Griseofulvan Heme pathway Hepatopathy alkaline phosphatase aspartate aminotransferase bilirubin bilirubin glucuronide griseofulvin heme porphyrin xenobiotic agent animal experiment animal tissue article cholestasis controlled study liver disease liver injury liver level long term exposure male microscopy mouse nonhuman priority journal topical drug administration Administration, Topical Animals Antibiotics, Antifungal Biological Markers Griseofulvin Heme Liver Liver Function Tests Male Mice Buzaleh, Ana María Vázquez, Elba Susana Afonso, Susana Graciela Batlle, Alcira María del Carmen Griseofulvin-induced hepatopathy due to abnormalities in heme pathways |
topic_facet |
Cholestasis Griseofulvan Heme pathway Hepatopathy alkaline phosphatase aspartate aminotransferase bilirubin bilirubin glucuronide griseofulvin heme porphyrin xenobiotic agent animal experiment animal tissue article cholestasis controlled study liver disease liver injury liver level long term exposure male microscopy mouse nonhuman priority journal topical drug administration Administration, Topical Animals Antibiotics, Antifungal Biological Markers Griseofulvin Heme Liver Liver Function Tests Male Mice |
description |
1. The effect of long term griseofulvin (GRIS) topical administration on some indica tors of liver damage was examined. 2. Liver porphyrin accumulation was significant; however, no porphyrin crystals were observed under light microscopy, 3. An earlier onset of hepatopathy was established (3-fold) increase of direct bilirubin values after 7 days of treatment; hepatic injury was confirmed by measuring a g fold increase of free bilirubin. 4. Enhanced values of alkaline phosphatase and glutamic oxalacetic transaminase (GOT) confirmed the onset of cholestasis. 5. Topical application of GRIS induced measurable hepatopathy. Nevertheless, we cannot discard the possibility that this hepatopathy could also be attributed in part to a direct reaction to xenobiotics. |
author |
Buzaleh, Ana María Vázquez, Elba Susana Afonso, Susana Graciela Batlle, Alcira María del Carmen |
author_facet |
Buzaleh, Ana María Vázquez, Elba Susana Afonso, Susana Graciela Batlle, Alcira María del Carmen |
author_sort |
Buzaleh, Ana María |
title |
Griseofulvin-induced hepatopathy due to abnormalities in heme pathways |
title_short |
Griseofulvin-induced hepatopathy due to abnormalities in heme pathways |
title_full |
Griseofulvin-induced hepatopathy due to abnormalities in heme pathways |
title_fullStr |
Griseofulvin-induced hepatopathy due to abnormalities in heme pathways |
title_full_unstemmed |
Griseofulvin-induced hepatopathy due to abnormalities in heme pathways |
title_sort |
griseofulvin-induced hepatopathy due to abnormalities in heme pathways |
publishDate |
1997 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v29_n2_p207_Polo http://hdl.handle.net/20.500.12110/paper_03063623_v29_n2_p207_Polo |
work_keys_str_mv |
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_version_ |
1768541610631495680 |