Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation
1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. δ-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was als...
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1997
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v28_n4_p577_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v28_n4_p577_Buzaleh |
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paper:paper_03063623_v28_n4_p577_Buzaleh2023-06-08T15:31:07Z Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation Buzaleh, Ana María Vázquez, Elba Susana Batlle, Alcira María del Carmen Chronic anesthesia Drug-metabolizing enzyme system Enflurane Heme metabolism Isoflurane 5 aminolevulinate synthase beta glucuronidase cytochrome p450 enflurane glutathione transferase isoflurane phenobarbital sulfatase tryptophan 2,3 dioxygenase anesthesia animal experiment article drug metabolism enzyme activity male mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Anesthetics, Inhalation Animals Cytochrome P-450 Enzyme System Enflurane Heme Hypnotics and Sedatives Isoflurane Liver Male Mice Phenobarbital Porphobilinogen Porphyrins 1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. δ-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was also enhanced, but these values were lower when animals also received PB. 3. Cytochrome (CYT) P-450 levels were enhanced in animals treated with enflurane whether or not they were given PB. 4. Gluthatione-S-transferase activity was induced by enflurane (138%) or isoflurane (174%), and even more in animals receiving PB also. Sulfatase activity was increased more than 60% with anesthetics. Isoflurane produced a 50% increase of β-glucuronidase activity and a 35% diminution of tryptophan pyrrolase. 5. The association between anesthetics and PB produced diverse effects on the metabolizing enzyme system. 6. Data suggest that both anesthetics, chemically related, could act through two different mechanisms, however, with the same final effect: heme pathway deregulation. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A.M.D.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v28_n4_p577_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v28_n4_p577_Buzaleh |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Chronic anesthesia Drug-metabolizing enzyme system Enflurane Heme metabolism Isoflurane 5 aminolevulinate synthase beta glucuronidase cytochrome p450 enflurane glutathione transferase isoflurane phenobarbital sulfatase tryptophan 2,3 dioxygenase anesthesia animal experiment article drug metabolism enzyme activity male mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Anesthetics, Inhalation Animals Cytochrome P-450 Enzyme System Enflurane Heme Hypnotics and Sedatives Isoflurane Liver Male Mice Phenobarbital Porphobilinogen Porphyrins |
| spellingShingle |
Chronic anesthesia Drug-metabolizing enzyme system Enflurane Heme metabolism Isoflurane 5 aminolevulinate synthase beta glucuronidase cytochrome p450 enflurane glutathione transferase isoflurane phenobarbital sulfatase tryptophan 2,3 dioxygenase anesthesia animal experiment article drug metabolism enzyme activity male mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Anesthetics, Inhalation Animals Cytochrome P-450 Enzyme System Enflurane Heme Hypnotics and Sedatives Isoflurane Liver Male Mice Phenobarbital Porphobilinogen Porphyrins Buzaleh, Ana María Vázquez, Elba Susana Batlle, Alcira María del Carmen Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation |
| topic_facet |
Chronic anesthesia Drug-metabolizing enzyme system Enflurane Heme metabolism Isoflurane 5 aminolevulinate synthase beta glucuronidase cytochrome p450 enflurane glutathione transferase isoflurane phenobarbital sulfatase tryptophan 2,3 dioxygenase anesthesia animal experiment article drug metabolism enzyme activity male mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Anesthetics, Inhalation Animals Cytochrome P-450 Enzyme System Enflurane Heme Hypnotics and Sedatives Isoflurane Liver Male Mice Phenobarbital Porphobilinogen Porphyrins |
| description |
1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. δ-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was also enhanced, but these values were lower when animals also received PB. 3. Cytochrome (CYT) P-450 levels were enhanced in animals treated with enflurane whether or not they were given PB. 4. Gluthatione-S-transferase activity was induced by enflurane (138%) or isoflurane (174%), and even more in animals receiving PB also. Sulfatase activity was increased more than 60% with anesthetics. Isoflurane produced a 50% increase of β-glucuronidase activity and a 35% diminution of tryptophan pyrrolase. 5. The association between anesthetics and PB produced diverse effects on the metabolizing enzyme system. 6. Data suggest that both anesthetics, chemically related, could act through two different mechanisms, however, with the same final effect: heme pathway deregulation. |
| author |
Buzaleh, Ana María Vázquez, Elba Susana Batlle, Alcira María del Carmen |
| author_facet |
Buzaleh, Ana María Vázquez, Elba Susana Batlle, Alcira María del Carmen |
| author_sort |
Buzaleh, Ana María |
| title |
Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation |
| title_short |
Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation |
| title_full |
Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation |
| title_fullStr |
Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation |
| title_full_unstemmed |
Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation |
| title_sort |
effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation |
| publishDate |
1997 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v28_n4_p577_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v28_n4_p577_Buzaleh |
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