Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice

The influence of strain and sex on the effect of enflurane and isoflurane administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. Enflurane produced 35% and 80% increases in ALA-S activity only...

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Autores principales:	Buzaleh, Ana María, Batlle, Alcira María del Carmen
Publicado:	1996
Materias:	acute intermittent porphyria enflurane heme metabolism isoflurane sex strain 5 aminolevulinate synthase heme porphobilinogen deaminase porphobilinogen synthase animal experiment animal model article controlled study enzyme activity enzyme blood level female heme synthesis intraperitoneal drug administration male metabolism mouse nonhuman priority journal sex difference strain difference
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v27_n6_p1009_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v27_n6_p1009_Buzaleh
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03063623_v27_n6_p1009_Buzaleh
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spelling	paper:paper_03063623_v27_n6_p1009_Buzaleh2023-06-08T15:31:07Z Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice Buzaleh, Ana María Batlle, Alcira María del Carmen acute intermittent porphyria enflurane heme metabolism isoflurane sex strain 5 aminolevulinate synthase enflurane heme isoflurane porphobilinogen deaminase porphobilinogen synthase acute intermittent porphyria animal experiment animal model article controlled study enzyme activity enzyme blood level female heme synthesis intraperitoneal drug administration male metabolism mouse nonhuman priority journal sex difference strain difference The influence of strain and sex on the effect of enflurane and isoflurane administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. Enflurane produced 35% and 80% increases in ALA-S activity only in CF1 male and female mice, respectively, whereas isoflurane induced 40% enzyme activity in CF1 male. CF1 males showed around 35% decrease in blood PBGase and PBG-deaminase after administration of enflurane, whereas isoflurane provoked a striking inhibition (70%) in males of the C57 strain. Enflurane produced alterations in heme synthesis, which would fit a model of acute porphyria in CF1 male mice. On the other hand, isoflurane would mimic biochemical alterations of this porphyria in C57 males. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Carmen Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1996 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v27_n6_p1009_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v27_n6_p1009_Buzaleh
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	acute intermittent porphyria enflurane heme metabolism isoflurane sex strain 5 aminolevulinate synthase enflurane heme isoflurane porphobilinogen deaminase porphobilinogen synthase acute intermittent porphyria animal experiment animal model article controlled study enzyme activity enzyme blood level female heme synthesis intraperitoneal drug administration male metabolism mouse nonhuman priority journal sex difference strain difference
spellingShingle	acute intermittent porphyria enflurane heme metabolism isoflurane sex strain 5 aminolevulinate synthase enflurane heme isoflurane porphobilinogen deaminase porphobilinogen synthase acute intermittent porphyria animal experiment animal model article controlled study enzyme activity enzyme blood level female heme synthesis intraperitoneal drug administration male metabolism mouse nonhuman priority journal sex difference strain difference Buzaleh, Ana María Batlle, Alcira María del Carmen Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice
topic_facet	acute intermittent porphyria enflurane heme metabolism isoflurane sex strain 5 aminolevulinate synthase enflurane heme isoflurane porphobilinogen deaminase porphobilinogen synthase acute intermittent porphyria animal experiment animal model article controlled study enzyme activity enzyme blood level female heme synthesis intraperitoneal drug administration male metabolism mouse nonhuman priority journal sex difference strain difference
description	The influence of strain and sex on the effect of enflurane and isoflurane administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. Enflurane produced 35% and 80% increases in ALA-S activity only in CF1 male and female mice, respectively, whereas isoflurane induced 40% enzyme activity in CF1 male. CF1 males showed around 35% decrease in blood PBGase and PBG-deaminase after administration of enflurane, whereas isoflurane provoked a striking inhibition (70%) in males of the C57 strain. Enflurane produced alterations in heme synthesis, which would fit a model of acute porphyria in CF1 male mice. On the other hand, isoflurane would mimic biochemical alterations of this porphyria in C57 males.
author	Buzaleh, Ana María Batlle, Alcira María del Carmen
author_facet	Buzaleh, Ana María Batlle, Alcira María del Carmen
author_sort	Buzaleh, Ana María
title	Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice
title_short	Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice
title_full	Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice
title_fullStr	Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice
title_full_unstemmed	Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice
title_sort	strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice
publishDate	1996
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v27_n6_p1009_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v27_n6_p1009_Buzaleh
work_keys_str_mv	AT buzalehanamaria strainandsexdifferencesintheeffectofenfluraneandisofluraneonhememetabolisminmice AT batllealciramariadelcarmen strainandsexdifferencesintheeffectofenfluraneandisofluraneonhememetabolisminmice
_version_	1768543180813238272

Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice

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