Effect of multiple doses of volatile anesthetics on heme enzymes

1. The effect of the administration of several doses of Enflurane and Isoflurane (2 ml/kg, i.p., daily) on heme metabolism and glucose levels was studied. 2. Liver and kidney δ-Aminolevulinic acid synthetase (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead...

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Autores principales:	Buzaleh, Ana María, Batlle, Alcira María del Carmen
Publicado:	1994
Materias:	acute porphyrias anesthetics Heme enzymes porphyrinogenic drugs 5 aminolevulinate synthase enflurane glucose inhalation anesthetic agent isoflurane liver enzyme porphobilinogen deaminase porphobilinogenase unclassified drug uroporphyrinogen acute intermittent porphyria animal experiment animal tissue article controlled study enzyme activity enzyme blood level enzyme induction heme synthesis intraperitoneal drug administration mouse nonhuman priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Dose-Response Relationship, Drug Enflurane Glucose Heme Isoflurane Kidney Liver Mice Mice, Inbred Strains Support, Non-U.S. Gov't
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v25_n6_p1179_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v25_n6_p1179_Buzaleh
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03063623_v25_n6_p1179_Buzaleh
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spelling	paper:paper_03063623_v25_n6_p1179_Buzaleh2023-06-08T15:31:06Z Effect of multiple doses of volatile anesthetics on heme enzymes Buzaleh, Ana María Batlle, Alcira María del Carmen acute porphyrias anesthetics Heme enzymes porphyrinogenic drugs 5 aminolevulinate synthase enflurane glucose inhalation anesthetic agent isoflurane liver enzyme porphobilinogen deaminase porphobilinogenase unclassified drug uroporphyrinogen acute intermittent porphyria animal experiment animal tissue article controlled study enzyme activity enzyme blood level enzyme induction heme synthesis intraperitoneal drug administration mouse nonhuman priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Dose-Response Relationship, Drug Enflurane Glucose Heme Isoflurane Kidney Liver Mice Mice, Inbred Strains Support, Non-U.S. Gov't 1. The effect of the administration of several doses of Enflurane and Isoflurane (2 ml/kg, i.p., daily) on heme metabolism and glucose levels was studied. 2. Liver and kidney δ-Aminolevulinic acid synthetase (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead induction of this enzyme was only detected, in animals receiving one dose of Isoflurane. 3. Blood Porphobilinogenase and deaminase (50%, P < 0.01) inhibition was produced only when animals received a single dose of the anesthetics. 5. ALA-S induction observed after the third dose of anesthetics could be a consequence of long lasting depletion in heme synthesis produced by blocking at uroporphyrinogen level. © 1994. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Batlle, C.A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1994 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v25_n6_p1179_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v25_n6_p1179_Buzaleh
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	acute porphyrias anesthetics Heme enzymes porphyrinogenic drugs 5 aminolevulinate synthase enflurane glucose inhalation anesthetic agent isoflurane liver enzyme porphobilinogen deaminase porphobilinogenase unclassified drug uroporphyrinogen acute intermittent porphyria animal experiment animal tissue article controlled study enzyme activity enzyme blood level enzyme induction heme synthesis intraperitoneal drug administration mouse nonhuman priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Dose-Response Relationship, Drug Enflurane Glucose Heme Isoflurane Kidney Liver Mice Mice, Inbred Strains Support, Non-U.S. Gov't
spellingShingle	acute porphyrias anesthetics Heme enzymes porphyrinogenic drugs 5 aminolevulinate synthase enflurane glucose inhalation anesthetic agent isoflurane liver enzyme porphobilinogen deaminase porphobilinogenase unclassified drug uroporphyrinogen acute intermittent porphyria animal experiment animal tissue article controlled study enzyme activity enzyme blood level enzyme induction heme synthesis intraperitoneal drug administration mouse nonhuman priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Dose-Response Relationship, Drug Enflurane Glucose Heme Isoflurane Kidney Liver Mice Mice, Inbred Strains Support, Non-U.S. Gov't Buzaleh, Ana María Batlle, Alcira María del Carmen Effect of multiple doses of volatile anesthetics on heme enzymes
topic_facet	acute porphyrias anesthetics Heme enzymes porphyrinogenic drugs 5 aminolevulinate synthase enflurane glucose inhalation anesthetic agent isoflurane liver enzyme porphobilinogen deaminase porphobilinogenase unclassified drug uroporphyrinogen acute intermittent porphyria animal experiment animal tissue article controlled study enzyme activity enzyme blood level enzyme induction heme synthesis intraperitoneal drug administration mouse nonhuman priority journal 5-Aminolevulinate Synthetase Ammonia-Lyases Animal Dose-Response Relationship, Drug Enflurane Glucose Heme Isoflurane Kidney Liver Mice Mice, Inbred Strains Support, Non-U.S. Gov't
description	1. The effect of the administration of several doses of Enflurane and Isoflurane (2 ml/kg, i.p., daily) on heme metabolism and glucose levels was studied. 2. Liver and kidney δ-Aminolevulinic acid synthetase (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead induction of this enzyme was only detected, in animals receiving one dose of Isoflurane. 3. Blood Porphobilinogenase and deaminase (50%, P < 0.01) inhibition was produced only when animals received a single dose of the anesthetics. 5. ALA-S induction observed after the third dose of anesthetics could be a consequence of long lasting depletion in heme synthesis produced by blocking at uroporphyrinogen level. © 1994.
author	Buzaleh, Ana María Batlle, Alcira María del Carmen
author_facet	Buzaleh, Ana María Batlle, Alcira María del Carmen
author_sort	Buzaleh, Ana María
title	Effect of multiple doses of volatile anesthetics on heme enzymes
title_short	Effect of multiple doses of volatile anesthetics on heme enzymes
title_full	Effect of multiple doses of volatile anesthetics on heme enzymes
title_fullStr	Effect of multiple doses of volatile anesthetics on heme enzymes
title_full_unstemmed	Effect of multiple doses of volatile anesthetics on heme enzymes
title_sort	effect of multiple doses of volatile anesthetics on heme enzymes
publishDate	1994
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v25_n6_p1179_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v25_n6_p1179_Buzaleh
work_keys_str_mv	AT buzalehanamaria effectofmultipledosesofvolatileanestheticsonhemeenzymes AT batllealciramariadelcarmen effectofmultipledosesofvolatileanestheticsonhemeenzymes
_version_	1768544410679640064

Effect of multiple doses of volatile anesthetics on heme enzymes

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