Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses

1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid d...

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Autores principales:	Buzaleh, Ana María, Vázquez, Elba Susana, Batlle, Alcira María del Carmen
Publicado:	1990
Materias:	cytochrome c oxidase porphobilinogen synthase s adenosylmethionine thiocyanate thiosulfate thiosulfate sulfurtransferase animal experiment article controlled study cyanide poisoning detoxification intraperitoneal drug administration mouse nonhuman priority journal Animal Cyanides Cytochrome-c Oxidase Lethal Dose 50 Mice Porphobilinogen Synthase Proteins S-Adenosylmethionine Sulfur Radioisotopes Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Thiosulfates
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n1_p27_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v21_n1_p27_Buzaleh
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03063623_v21_n1_p27_Buzaleh
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spelling	paper:paper_03063623_v21_n1_p27_Buzaleh2023-06-08T15:31:04Z Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses Buzaleh, Ana María Vázquez, Elba Susana Batlle, Alcira María del Carmen cytochrome c oxidase porphobilinogen synthase s adenosylmethionine thiocyanate thiosulfate thiosulfate sulfurtransferase animal experiment article controlled study cyanide poisoning detoxification intraperitoneal drug administration mouse nonhuman priority journal Animal Cyanides Cytochrome-c Oxidase Lethal Dose 50 Mice Porphobilinogen Synthase Proteins S-Adenosylmethionine Sulfur Radioisotopes Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Thiosulfates 1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid dehydratase (ALA-D) activity. 3. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered. © 1990. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Carmen Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n1_p27_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v21_n1_p27_Buzaleh
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	cytochrome c oxidase porphobilinogen synthase s adenosylmethionine thiocyanate thiosulfate thiosulfate sulfurtransferase animal experiment article controlled study cyanide poisoning detoxification intraperitoneal drug administration mouse nonhuman priority journal Animal Cyanides Cytochrome-c Oxidase Lethal Dose 50 Mice Porphobilinogen Synthase Proteins S-Adenosylmethionine Sulfur Radioisotopes Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Thiosulfates
spellingShingle	cytochrome c oxidase porphobilinogen synthase s adenosylmethionine thiocyanate thiosulfate thiosulfate sulfurtransferase animal experiment article controlled study cyanide poisoning detoxification intraperitoneal drug administration mouse nonhuman priority journal Animal Cyanides Cytochrome-c Oxidase Lethal Dose 50 Mice Porphobilinogen Synthase Proteins S-Adenosylmethionine Sulfur Radioisotopes Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Thiosulfates Buzaleh, Ana María Vázquez, Elba Susana Batlle, Alcira María del Carmen Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses
topic_facet	cytochrome c oxidase porphobilinogen synthase s adenosylmethionine thiocyanate thiosulfate thiosulfate sulfurtransferase animal experiment article controlled study cyanide poisoning detoxification intraperitoneal drug administration mouse nonhuman priority journal Animal Cyanides Cytochrome-c Oxidase Lethal Dose 50 Mice Porphobilinogen Synthase Proteins S-Adenosylmethionine Sulfur Radioisotopes Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Thiosulfates
description	1. 1. The effect of acute cyanide administration to mice in a lethal and a non-lethal dose and the anti-cyanide effect of S-adenosyl-l-methionine (SAM) and thiosulphate were investigated. 2. 2. The poisoning action was determined by measuring cytochrome oxidase, rhodanese and δ-aminolevulinic acid dehydratase (ALA-D) activity. 3. 3. The toxic metabolizing degree was investigated by measuring plasma and urine thiocyanate levels. 4. 4. The state of the sulfane sulfur pool was investigated by determining cyanide labile-sulfur levels. 5. 5. These results support the belief that rhodanese plays a fundamental role in the detoxification process only when high levels of cyanide are administered. © 1990.
author	Buzaleh, Ana María Vázquez, Elba Susana Batlle, Alcira María del Carmen
author_facet	Buzaleh, Ana María Vázquez, Elba Susana Batlle, Alcira María del Carmen
author_sort	Buzaleh, Ana María
title	Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses
title_short	Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses
title_full	Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses
title_fullStr	Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses
title_full_unstemmed	Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses
title_sort	cyanide intoxication-iii. on the analogous and different effects provoked by non-lethal and lethal challenged doses
publishDate	1990
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v21_n1_p27_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v21_n1_p27_Buzaleh
work_keys_str_mv	AT buzalehanamaria cyanideintoxicationiiiontheanalogousanddifferenteffectsprovokedbynonlethalandlethalchallengeddoses AT vazquezelbasusana cyanideintoxicationiiiontheanalogousanddifferenteffectsprovokedbynonlethalandlethalchallengeddoses AT batllealciramariadelcarmen cyanideintoxicationiiiontheanalogousanddifferenteffectsprovokedbynonlethalandlethalchallengeddoses
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Cyanide intoxication-III. On the analogous and different effects provoked by non-lethal and lethal challenged doses

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