Cyanide intoxication-I. An oral chronic animal model

The effects of oral chronic cyanide administration to mice were studied. Cyanide intoxication was confirmed by the increased levels of this poison and the concomitant inhibition of cytochrome oxidase activity in liver, brain, heart and blood. The detoxifying enzyme rhodanese was measured. The state...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Buzaleh, Ana María, Vázquez, Elba Susana
Publicado:	1989
Materias:	cyanide cytochrome c oxidase thiocyanate thiosulfate sulfurtransferase animal cell animal experiment animal model blood brain detoxification heart intoxication liver mouse nonhuman priority journal Administration, Oral Animal Cyanides Cytochrome-c Oxidase Mice Proteins Sulfur Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Time Factors
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v20_n3_p323_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v20_n3_p323_Buzaleh
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03063623_v20_n3_p323_Buzaleh
record_format	dspace
spelling	paper:paper_03063623_v20_n3_p323_Buzaleh2023-06-08T15:31:03Z Cyanide intoxication-I. An oral chronic animal model Buzaleh, Ana María Vázquez, Elba Susana cyanide cytochrome c oxidase thiocyanate thiosulfate sulfurtransferase animal cell animal experiment animal model blood brain detoxification heart intoxication liver mouse nonhuman priority journal Administration, Oral Animal Cyanides Cytochrome-c Oxidase Mice Proteins Sulfur Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Time Factors The effects of oral chronic cyanide administration to mice were studied. Cyanide intoxication was confirmed by the increased levels of this poison and the concomitant inhibition of cytochrome oxidase activity in liver, brain, heart and blood. The detoxifying enzyme rhodanese was measured. The state of the sulfane sulfur pool was investigated by determination of the cyanide labile-sulfur levels. A clear correlation between rhodanese activity and sulfur content was obtained as a consequence of cyanide action. These results support the belief that rhodanese plays a fundamental role in the detoxification process of cyanide, in preventing cyanide reaching the target tissues. © 1989. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1989 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v20_n3_p323_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v20_n3_p323_Buzaleh
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	cyanide cytochrome c oxidase thiocyanate thiosulfate sulfurtransferase animal cell animal experiment animal model blood brain detoxification heart intoxication liver mouse nonhuman priority journal Administration, Oral Animal Cyanides Cytochrome-c Oxidase Mice Proteins Sulfur Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Time Factors
spellingShingle	cyanide cytochrome c oxidase thiocyanate thiosulfate sulfurtransferase animal cell animal experiment animal model blood brain detoxification heart intoxication liver mouse nonhuman priority journal Administration, Oral Animal Cyanides Cytochrome-c Oxidase Mice Proteins Sulfur Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Time Factors Buzaleh, Ana María Vázquez, Elba Susana Cyanide intoxication-I. An oral chronic animal model
topic_facet	cyanide cytochrome c oxidase thiocyanate thiosulfate sulfurtransferase animal cell animal experiment animal model blood brain detoxification heart intoxication liver mouse nonhuman priority journal Administration, Oral Animal Cyanides Cytochrome-c Oxidase Mice Proteins Sulfur Support, Non-U.S. Gov't Thiocyanates Thiosulfate Sulfurtransferase Time Factors
description	The effects of oral chronic cyanide administration to mice were studied. Cyanide intoxication was confirmed by the increased levels of this poison and the concomitant inhibition of cytochrome oxidase activity in liver, brain, heart and blood. The detoxifying enzyme rhodanese was measured. The state of the sulfane sulfur pool was investigated by determination of the cyanide labile-sulfur levels. A clear correlation between rhodanese activity and sulfur content was obtained as a consequence of cyanide action. These results support the belief that rhodanese plays a fundamental role in the detoxification process of cyanide, in preventing cyanide reaching the target tissues. © 1989.
author	Buzaleh, Ana María Vázquez, Elba Susana
author_facet	Buzaleh, Ana María Vázquez, Elba Susana
author_sort	Buzaleh, Ana María
title	Cyanide intoxication-I. An oral chronic animal model
title_short	Cyanide intoxication-I. An oral chronic animal model
title_full	Cyanide intoxication-I. An oral chronic animal model
title_fullStr	Cyanide intoxication-I. An oral chronic animal model
title_full_unstemmed	Cyanide intoxication-I. An oral chronic animal model
title_sort	cyanide intoxication-i. an oral chronic animal model
publishDate	1989
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v20_n3_p323_Buzaleh http://hdl.handle.net/20.500.12110/paper_03063623_v20_n3_p323_Buzaleh
work_keys_str_mv	AT buzalehanamaria cyanideintoxicationianoralchronicanimalmodel AT vazquezelbasusana cyanideintoxicationianoralchronicanimalmodel
_version_	1768546116066869248

Cyanide intoxication-I. An oral chronic animal model

Ejemplares similares