The eukaryotic linear motif resource - 2018 update

Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manua...

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Detalles Bibliográficos
Publicado:	2018
Materias:	protein kinase protein kinase kinome unclassified drug amino acid sequence application programmatic interface Article cell cycle enzyme structure eukaryote eukaryotic linear motif factual database human nonhuman priority journal protein binding protein database protein motif short linear motif
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03051048_v46_nD1_pD428_Gouw http://hdl.handle.net/20.500.12110/paper_03051048_v46_nD1_pD428_Gouw
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03051048_v46_nD1_pD428_Gouw
record_format	dspace
spelling	paper:paper_03051048_v46_nD1_pD428_Gouw2023-06-08T15:30:33Z The eukaryotic linear motif resource - 2018 update protein kinase protein kinase kinome unclassified drug amino acid sequence application programmatic interface Article cell cycle enzyme structure eukaryote eukaryotic linear motif factual database human nonhuman priority journal protein binding protein database protein motif short linear motif Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03051048_v46_nD1_pD428_Gouw http://hdl.handle.net/20.500.12110/paper_03051048_v46_nD1_pD428_Gouw
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	protein kinase protein kinase kinome unclassified drug amino acid sequence application programmatic interface Article cell cycle enzyme structure eukaryote eukaryotic linear motif factual database human nonhuman priority journal protein binding protein database protein motif short linear motif
spellingShingle	protein kinase protein kinase kinome unclassified drug amino acid sequence application programmatic interface Article cell cycle enzyme structure eukaryote eukaryotic linear motif factual database human nonhuman priority journal protein binding protein database protein motif short linear motif The eukaryotic linear motif resource - 2018 update
topic_facet	protein kinase protein kinase kinome unclassified drug amino acid sequence application programmatic interface Article cell cycle enzyme structure eukaryote eukaryotic linear motif factual database human nonhuman priority journal protein binding protein database protein motif short linear motif
description	Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.
title	The eukaryotic linear motif resource - 2018 update
title_short	The eukaryotic linear motif resource - 2018 update
title_full	The eukaryotic linear motif resource - 2018 update
title_fullStr	The eukaryotic linear motif resource - 2018 update
title_full_unstemmed	The eukaryotic linear motif resource - 2018 update
title_sort	eukaryotic linear motif resource - 2018 update
publishDate	2018
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03051048_v46_nD1_pD428_Gouw http://hdl.handle.net/20.500.12110/paper_03051048_v46_nD1_pD428_Gouw
_version_	1768543560922038272

The eukaryotic linear motif resource - 2018 update

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