S-adenosyl-l-methionine a counter to lead intoxication?

1. 1. The effect of S-adenosyl-l-methionine (SAM) administration to both acute and chronic lead exposed mice was investigated. 2. 2. SAM was given s.c. at different doses and for different time intervals. The best results were obtained using 20 mg SAM/kg applied daily over a period of 20-22 days. 3....

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Autores principales:	Paredes, Sergio Raúl, Batlle, Alcira María del Carmen
Publicado:	1985
Materias:	glutathione porphobilinogen synthase s adenosylmethionine acute disease animal article kidney kinetics lead poisoning liver male metabolism mouse spleen Acute Disease Animal Glutathione Kidney Kinetics Lead Poisoning Liver Male Mice Porphobilinogen Synthase S-Adenosylmethionine Spleen Support, Non-U.S. Gov't
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v82_n4_p751_Paredes http://hdl.handle.net/20.500.12110/paper_03050491_v82_n4_p751_Paredes
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03050491_v82_n4_p751_Paredes
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spelling	paper:paper_03050491_v82_n4_p751_Paredes2023-06-08T15:30:20Z S-adenosyl-l-methionine a counter to lead intoxication? Paredes, Sergio Raúl Batlle, Alcira María del Carmen glutathione porphobilinogen synthase s adenosylmethionine acute disease animal article kidney kinetics lead poisoning liver male metabolism mouse spleen Acute Disease Animal Glutathione Kidney Kinetics Lead Poisoning Liver Male Mice Porphobilinogen Synthase S-Adenosylmethionine Spleen Support, Non-U.S. Gov't 1. 1. The effect of S-adenosyl-l-methionine (SAM) administration to both acute and chronic lead exposed mice was investigated. 2. 2. SAM was given s.c. at different doses and for different time intervals. The best results were obtained using 20 mg SAM/kg applied daily over a period of 20-22 days. 3. 3. Results obtained in both acute and chronic lead poisoning were quite similar. 4. 4. GSH concentration in blood and liver, reduced in intoxicated animals was increased after SAM administration reaching normal values. 5. 5. Blood, liver and kidney lead content notably increased at the beginning of SAM treatment and decreased rapidly in the group receiving SAM, attaining values near control levels in 2 weeks. 6. 6. A significant recovery of blood, liver, kidney, spleen and brain δ-aminolevulic acid dehydratase (ALA-D) initially reduced in poisoned animals, was clearly produced after SAM administration. 7. 7. A clear and direct correlation between the recovery of both ALA-D activity and GSH levels and the decreased concentration of lead in tissues was observed, reinforcing our proposal that enhancement of thiol content as a result of SAM administration would facilitate the detoxification process and lead removal, consequently reversing the inactivation of the enzyme. 8. 8. We conclude that SAM therapy is beneficial in the treatment of lead intoxication. © 1985. Fil:Paredes, S.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1985 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v82_n4_p751_Paredes http://hdl.handle.net/20.500.12110/paper_03050491_v82_n4_p751_Paredes
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	glutathione porphobilinogen synthase s adenosylmethionine acute disease animal article kidney kinetics lead poisoning liver male metabolism mouse spleen Acute Disease Animal Glutathione Kidney Kinetics Lead Poisoning Liver Male Mice Porphobilinogen Synthase S-Adenosylmethionine Spleen Support, Non-U.S. Gov't
spellingShingle	glutathione porphobilinogen synthase s adenosylmethionine acute disease animal article kidney kinetics lead poisoning liver male metabolism mouse spleen Acute Disease Animal Glutathione Kidney Kinetics Lead Poisoning Liver Male Mice Porphobilinogen Synthase S-Adenosylmethionine Spleen Support, Non-U.S. Gov't Paredes, Sergio Raúl Batlle, Alcira María del Carmen S-adenosyl-l-methionine a counter to lead intoxication?
topic_facet	glutathione porphobilinogen synthase s adenosylmethionine acute disease animal article kidney kinetics lead poisoning liver male metabolism mouse spleen Acute Disease Animal Glutathione Kidney Kinetics Lead Poisoning Liver Male Mice Porphobilinogen Synthase S-Adenosylmethionine Spleen Support, Non-U.S. Gov't
description	1. 1. The effect of S-adenosyl-l-methionine (SAM) administration to both acute and chronic lead exposed mice was investigated. 2. 2. SAM was given s.c. at different doses and for different time intervals. The best results were obtained using 20 mg SAM/kg applied daily over a period of 20-22 days. 3. 3. Results obtained in both acute and chronic lead poisoning were quite similar. 4. 4. GSH concentration in blood and liver, reduced in intoxicated animals was increased after SAM administration reaching normal values. 5. 5. Blood, liver and kidney lead content notably increased at the beginning of SAM treatment and decreased rapidly in the group receiving SAM, attaining values near control levels in 2 weeks. 6. 6. A significant recovery of blood, liver, kidney, spleen and brain δ-aminolevulic acid dehydratase (ALA-D) initially reduced in poisoned animals, was clearly produced after SAM administration. 7. 7. A clear and direct correlation between the recovery of both ALA-D activity and GSH levels and the decreased concentration of lead in tissues was observed, reinforcing our proposal that enhancement of thiol content as a result of SAM administration would facilitate the detoxification process and lead removal, consequently reversing the inactivation of the enzyme. 8. 8. We conclude that SAM therapy is beneficial in the treatment of lead intoxication. © 1985.
author	Paredes, Sergio Raúl Batlle, Alcira María del Carmen
author_facet	Paredes, Sergio Raúl Batlle, Alcira María del Carmen
author_sort	Paredes, Sergio Raúl
title	S-adenosyl-l-methionine a counter to lead intoxication?
title_short	S-adenosyl-l-methionine a counter to lead intoxication?
title_full	S-adenosyl-l-methionine a counter to lead intoxication?
title_fullStr	S-adenosyl-l-methionine a counter to lead intoxication?
title_full_unstemmed	S-adenosyl-l-methionine a counter to lead intoxication?
title_sort	s-adenosyl-l-methionine a counter to lead intoxication?
publishDate	1985
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v82_n4_p751_Paredes http://hdl.handle.net/20.500.12110/paper_03050491_v82_n4_p751_Paredes
work_keys_str_mv	AT paredessergioraul sadenosyllmethionineacountertoleadintoxication AT batllealciramariadelcarmen sadenosyllmethionineacountertoleadintoxication
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S-adenosyl-l-methionine a counter to lead intoxication?

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