Steroid biosynthesis in the gonads of the teleost fish Jenynsia lineata

1. 1. A series of enzyme systems for steroid biosynthesis in the ovary and testis of Jenynsia lineata were demonstrated in vitro. In the ovary and testis of this teleost the following enzymic conversions of radiolabelled steroid substrates were observed in vitro: Pregnenolone → 17α-hydroxypregnenolo...

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Detalles Bibliográficos
Autores principales:	Tesone, Marta, Charreau, Eduardo Hernán
Publicado:	1980
Materias:	steroid biosynthesis endocrine system female genital system fish gonad male genital system
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v65_n4_p631_Tesone http://hdl.handle.net/20.500.12110/paper_03050491_v65_n4_p631_Tesone
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03050491_v65_n4_p631_Tesone
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spelling	paper:paper_03050491_v65_n4_p631_Tesone2023-06-08T15:30:18Z Steroid biosynthesis in the gonads of the teleost fish Jenynsia lineata Tesone, Marta Charreau, Eduardo Hernán steroid biosynthesis endocrine system female genital system fish gonad male genital system 1. 1. A series of enzyme systems for steroid biosynthesis in the ovary and testis of Jenynsia lineata were demonstrated in vitro. In the ovary and testis of this teleost the following enzymic conversions of radiolabelled steroid substrates were observed in vitro: Pregnenolone → 17α-hydroxypregnenolone plus androstenedione and testosterone and Pregnenolone → 17α-hydroxyprogesterone plus androstenedione and testosterone. 2. 2. In addition, an unusual finding in the ovary and testes was the biosynthesis of 11-deoxycortisol (compound S) from the pregnenolone and progesterone substrates and the 21-hydroxylation of progesterone to form 11-deoxycorticosterone (DOC). 3. 3. The male gonad also exhibited 11β-hydroxylase activity and testosterone was converted to 11β-hydroxyandrostenedione. 4. 4. All conversions of radiolabelled substrates were identified on the basis of reverse isotope dilution and crystallization to constant specific activity. 5. 5. The physiological significance of DOC and 11β-hydroxyandrostenedione biosynthesis in the gonads of Jenynsia lineata and its possible role in the reproductive process are viewed against similar findings in other fishes. © 1980. Fil:Tesone, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Charreau, E.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1980 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v65_n4_p631_Tesone http://hdl.handle.net/20.500.12110/paper_03050491_v65_n4_p631_Tesone
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	steroid biosynthesis endocrine system female genital system fish gonad male genital system
spellingShingle	steroid biosynthesis endocrine system female genital system fish gonad male genital system Tesone, Marta Charreau, Eduardo Hernán Steroid biosynthesis in the gonads of the teleost fish Jenynsia lineata
topic_facet	steroid biosynthesis endocrine system female genital system fish gonad male genital system
description	1. 1. A series of enzyme systems for steroid biosynthesis in the ovary and testis of Jenynsia lineata were demonstrated in vitro. In the ovary and testis of this teleost the following enzymic conversions of radiolabelled steroid substrates were observed in vitro: Pregnenolone → 17α-hydroxypregnenolone plus androstenedione and testosterone and Pregnenolone → 17α-hydroxyprogesterone plus androstenedione and testosterone. 2. 2. In addition, an unusual finding in the ovary and testes was the biosynthesis of 11-deoxycortisol (compound S) from the pregnenolone and progesterone substrates and the 21-hydroxylation of progesterone to form 11-deoxycorticosterone (DOC). 3. 3. The male gonad also exhibited 11β-hydroxylase activity and testosterone was converted to 11β-hydroxyandrostenedione. 4. 4. All conversions of radiolabelled substrates were identified on the basis of reverse isotope dilution and crystallization to constant specific activity. 5. 5. The physiological significance of DOC and 11β-hydroxyandrostenedione biosynthesis in the gonads of Jenynsia lineata and its possible role in the reproductive process are viewed against similar findings in other fishes. © 1980.
author	Tesone, Marta Charreau, Eduardo Hernán
author_facet	Tesone, Marta Charreau, Eduardo Hernán
author_sort	Tesone, Marta
title	Steroid biosynthesis in the gonads of the teleost fish Jenynsia lineata
title_short	Steroid biosynthesis in the gonads of the teleost fish Jenynsia lineata
title_full	Steroid biosynthesis in the gonads of the teleost fish Jenynsia lineata
title_fullStr	Steroid biosynthesis in the gonads of the teleost fish Jenynsia lineata
title_full_unstemmed	Steroid biosynthesis in the gonads of the teleost fish Jenynsia lineata
title_sort	steroid biosynthesis in the gonads of the teleost fish jenynsia lineata
publishDate	1980
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v65_n4_p631_Tesone http://hdl.handle.net/20.500.12110/paper_03050491_v65_n4_p631_Tesone
work_keys_str_mv	AT tesonemarta steroidbiosynthesisinthegonadsoftheteleostfishjenynsialineata AT charreaueduardohernan steroidbiosynthesisinthegonadsoftheteleostfishjenynsialineata
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Steroid biosynthesis in the gonads of the teleost fish Jenynsia lineata

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