Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid
1. 1. Using different doses of free and liposome encapsulated aminolevulinic acid (ALA) (between 2 and 8 mg/animal), given i.p., s.c. and intra-tumoural (i.t.), in vivo porphyrin synthesis by tumour, red blood cells (RBC) and different organs from tumour-bearing mice (TBM) and normal mice (NM) at di...
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1992
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v102_n2_p433_Fukuda http://hdl.handle.net/20.500.12110/paper_03050491_v102_n2_p433_Fukuda |
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paper:paper_03050491_v102_n2_p433_Fukuda2023-06-08T15:30:17Z Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid Fukuda, Haydeé Paredes, Sergio Raúl aminolevulinic acid liposome porphyrin animal experiment animal tissue article cancer controlled study encapsulation intraperitoneal drug administration intratumoral drug administration mouse nonhuman priority journal subcutaneous drug administration tissue distribution tumor Aminolevulinic Acid Animal Drug Carriers Liposomes Male Mice Mice, Inbred BALB C Neoplasms, Experimental Organ Specificity Porphyrins Support, Non-U.S. Gov't Animalia 1. 1. Using different doses of free and liposome encapsulated aminolevulinic acid (ALA) (between 2 and 8 mg/animal), given i.p., s.c. and intra-tumoural (i.t.), in vivo porphyrin synthesis by tumour, red blood cells (RBC) and different organs from tumour-bearing mice (TBM) and normal mice (NM) at different times, up to 24 hr after ALA administration, was examined. 2. 2. It was found that by giving entrapped ALA, at a dose of 6 mg/animal (or 200 mg/kg wt), after 10 hr, a high level of porphyrin accumulation in the tumour was produced (7 μg/g tissue). Low synthesis occurred in muscle, lung, brain, RBC and skin; in spleen, kidney and liver synthesis is significant after 10 hr, but after 24 hr returned to normal values in the spleen and to about 2-3 μg/g tissue in the kidney and liver. 3. 3. The tumour/skin porphyrin concentration ratio after 10 hr was nearly 30, the highest so far reported. 4. 4. These results support our previous in vitro findings, indicating that free or encapsulated ALA might be used for early diagnosis of cancer and in photodynamic therapy. © 1992. Fil:Fukuda, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Paredes, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1992 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v102_n2_p433_Fukuda http://hdl.handle.net/20.500.12110/paper_03050491_v102_n2_p433_Fukuda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
aminolevulinic acid liposome porphyrin animal experiment animal tissue article cancer controlled study encapsulation intraperitoneal drug administration intratumoral drug administration mouse nonhuman priority journal subcutaneous drug administration tissue distribution tumor Aminolevulinic Acid Animal Drug Carriers Liposomes Male Mice Mice, Inbred BALB C Neoplasms, Experimental Organ Specificity Porphyrins Support, Non-U.S. Gov't Animalia |
| spellingShingle |
aminolevulinic acid liposome porphyrin animal experiment animal tissue article cancer controlled study encapsulation intraperitoneal drug administration intratumoral drug administration mouse nonhuman priority journal subcutaneous drug administration tissue distribution tumor Aminolevulinic Acid Animal Drug Carriers Liposomes Male Mice Mice, Inbred BALB C Neoplasms, Experimental Organ Specificity Porphyrins Support, Non-U.S. Gov't Animalia Fukuda, Haydeé Paredes, Sergio Raúl Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid |
| topic_facet |
aminolevulinic acid liposome porphyrin animal experiment animal tissue article cancer controlled study encapsulation intraperitoneal drug administration intratumoral drug administration mouse nonhuman priority journal subcutaneous drug administration tissue distribution tumor Aminolevulinic Acid Animal Drug Carriers Liposomes Male Mice Mice, Inbred BALB C Neoplasms, Experimental Organ Specificity Porphyrins Support, Non-U.S. Gov't Animalia |
| description |
1. 1. Using different doses of free and liposome encapsulated aminolevulinic acid (ALA) (between 2 and 8 mg/animal), given i.p., s.c. and intra-tumoural (i.t.), in vivo porphyrin synthesis by tumour, red blood cells (RBC) and different organs from tumour-bearing mice (TBM) and normal mice (NM) at different times, up to 24 hr after ALA administration, was examined. 2. 2. It was found that by giving entrapped ALA, at a dose of 6 mg/animal (or 200 mg/kg wt), after 10 hr, a high level of porphyrin accumulation in the tumour was produced (7 μg/g tissue). Low synthesis occurred in muscle, lung, brain, RBC and skin; in spleen, kidney and liver synthesis is significant after 10 hr, but after 24 hr returned to normal values in the spleen and to about 2-3 μg/g tissue in the kidney and liver. 3. 3. The tumour/skin porphyrin concentration ratio after 10 hr was nearly 30, the highest so far reported. 4. 4. These results support our previous in vitro findings, indicating that free or encapsulated ALA might be used for early diagnosis of cancer and in photodynamic therapy. © 1992. |
| author |
Fukuda, Haydeé Paredes, Sergio Raúl |
| author_facet |
Fukuda, Haydeé Paredes, Sergio Raúl |
| author_sort |
Fukuda, Haydeé |
| title |
Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid |
| title_short |
Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid |
| title_full |
Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid |
| title_fullStr |
Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid |
| title_full_unstemmed |
Tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid |
| title_sort |
tumour-localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolevulinic acid |
| publishDate |
1992 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v102_n2_p433_Fukuda http://hdl.handle.net/20.500.12110/paper_03050491_v102_n2_p433_Fukuda |
| work_keys_str_mv |
AT fukudahaydee tumourlocalizingpropertiesofporphyrinsinvivostudiesusingfreeandliposomeencapsulatedaminolevulinicacid AT paredessergioraul tumourlocalizingpropertiesofporphyrinsinvivostudiesusingfreeandliposomeencapsulatedaminolevulinicacid |
| _version_ |
1768544912692740096 |