Regulation of heme pathway in regenerating mouse liver
1. 1. δ-Aminolevulinic acid synthetase (ALA-S), rhodanese and microsomal heme oxygenase (MHO), were quantitated in Cl4C induced regenerating mouse liver. 2. 2. Maximal hepatomegalia was observed at 48 hr after i.p. injection of a single dose of the toxin. 3. 3. ALA-S activity decreased on day 2, and...
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1992
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v101_n1-2_p243_Polo http://hdl.handle.net/20.500.12110/paper_03050491_v101_n1-2_p243_Polo |
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paper:paper_03050491_v101_n1-2_p243_Polo2023-06-08T15:30:16Z Regulation of heme pathway in regenerating mouse liver Vázquez, Elba Susana 5 aminolevulinate synthase carbon tetrachloride heme oxygenase thiosulfate sulfurtransferase animal experiment animal tissue article liver regeneration liver toxicity mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carbon Tetrachloride Cytochrome P-450 Enzyme System Heme Heme Oxygenase (Decyclizing) Kinetics Liver Liver Regeneration Mice Microsomes, Liver Porphyrins Support, Non-U.S. Gov't Thiosulfate Sulfurtransferase 1. 1. δ-Aminolevulinic acid synthetase (ALA-S), rhodanese and microsomal heme oxygenase (MHO), were quantitated in Cl4C induced regenerating mouse liver. 2. 2. Maximal hepatomegalia was observed at 48 hr after i.p. injection of a single dose of the toxin. 3. 3. ALA-S activity decreased on day 2, and then significantly increased (50%) between days 3 and 7, returning afterwards to control values. 4. 4. Cytoplasmic rhodanese, as well as MHO activities, exhibited a clear correlation as compared with the ALA-S activity profile. 5. 5. Porphyrin biosynthesis from precursor δ-aminolevulinic acid (ALA) was significantly increased even after 15 days of intoxication. 6. 6. Present results would indicate that Cl4C is acting in a dual fashion. © 1992. Fil:Vazquez, E.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1992 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v101_n1-2_p243_Polo http://hdl.handle.net/20.500.12110/paper_03050491_v101_n1-2_p243_Polo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
5 aminolevulinate synthase carbon tetrachloride heme oxygenase thiosulfate sulfurtransferase animal experiment animal tissue article liver regeneration liver toxicity mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carbon Tetrachloride Cytochrome P-450 Enzyme System Heme Heme Oxygenase (Decyclizing) Kinetics Liver Liver Regeneration Mice Microsomes, Liver Porphyrins Support, Non-U.S. Gov't Thiosulfate Sulfurtransferase |
| spellingShingle |
5 aminolevulinate synthase carbon tetrachloride heme oxygenase thiosulfate sulfurtransferase animal experiment animal tissue article liver regeneration liver toxicity mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carbon Tetrachloride Cytochrome P-450 Enzyme System Heme Heme Oxygenase (Decyclizing) Kinetics Liver Liver Regeneration Mice Microsomes, Liver Porphyrins Support, Non-U.S. Gov't Thiosulfate Sulfurtransferase Vázquez, Elba Susana Regulation of heme pathway in regenerating mouse liver |
| topic_facet |
5 aminolevulinate synthase carbon tetrachloride heme oxygenase thiosulfate sulfurtransferase animal experiment animal tissue article liver regeneration liver toxicity mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carbon Tetrachloride Cytochrome P-450 Enzyme System Heme Heme Oxygenase (Decyclizing) Kinetics Liver Liver Regeneration Mice Microsomes, Liver Porphyrins Support, Non-U.S. Gov't Thiosulfate Sulfurtransferase |
| description |
1. 1. δ-Aminolevulinic acid synthetase (ALA-S), rhodanese and microsomal heme oxygenase (MHO), were quantitated in Cl4C induced regenerating mouse liver. 2. 2. Maximal hepatomegalia was observed at 48 hr after i.p. injection of a single dose of the toxin. 3. 3. ALA-S activity decreased on day 2, and then significantly increased (50%) between days 3 and 7, returning afterwards to control values. 4. 4. Cytoplasmic rhodanese, as well as MHO activities, exhibited a clear correlation as compared with the ALA-S activity profile. 5. 5. Porphyrin biosynthesis from precursor δ-aminolevulinic acid (ALA) was significantly increased even after 15 days of intoxication. 6. 6. Present results would indicate that Cl4C is acting in a dual fashion. © 1992. |
| author |
Vázquez, Elba Susana |
| author_facet |
Vázquez, Elba Susana |
| author_sort |
Vázquez, Elba Susana |
| title |
Regulation of heme pathway in regenerating mouse liver |
| title_short |
Regulation of heme pathway in regenerating mouse liver |
| title_full |
Regulation of heme pathway in regenerating mouse liver |
| title_fullStr |
Regulation of heme pathway in regenerating mouse liver |
| title_full_unstemmed |
Regulation of heme pathway in regenerating mouse liver |
| title_sort |
regulation of heme pathway in regenerating mouse liver |
| publishDate |
1992 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v101_n1-2_p243_Polo http://hdl.handle.net/20.500.12110/paper_03050491_v101_n1-2_p243_Polo |
| work_keys_str_mv |
AT vazquezelbasusana regulationofhemepathwayinregeneratingmouseliver |
| _version_ |
1768545094250528768 |