Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro
Rat pineal glands incubated in vitro with 10 or 100 μM norepinephrine (NE) released 51% and 415% more prostaglandin E2 (PGE2) to the medium than in the absence of NE. Phentolamine (10 μM) prevented fully the effect of NE at both concentrations, whereas propranolol failed to affect it significantly....
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1982
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v31_n3_p307_Ritta http://hdl.handle.net/20.500.12110/paper_03043940_v31_n3_p307_Ritta |
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paper:paper_03043940_v31_n3_p307_Ritta |
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paper:paper_03043940_v31_n3_p307_Ritta2023-06-08T15:29:30Z Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro adrenergic supersensitivity norepinephrine pineal gland prostaglandins superior cervical ganglion α-adrenoceptors alpha adrenergic receptor noradrenalin phentolamine propranolol prostaglandin prostaglandin e2 animal experiment endocrine system in vitro study pineal body rat Adrenergic Fibers Animal Denervation Dinoprostone Dose-Response Relationship, Drug Ganglia, Sympathetic Male Norepinephrine Pineal Gland Prostaglandins E Radioimmunoassay Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Support, Non-U.S. Gov't Rat pineal glands incubated in vitro with 10 or 100 μM norepinephrine (NE) released 51% and 415% more prostaglandin E2 (PGE2) to the medium than in the absence of NE. Phentolamine (10 μM) prevented fully the effect of NE at both concentrations, whereas propranolol failed to affect it significantly. After superior cervical ganglionectomy (SCGx), NE-induced PGE2 release was significantly higher than in sham-operated controls - an effect also blocked by phentolamine but not by oropranolol. These results suggest that NE releases PGE2 in rat pineals via α-adrenoceptors, acting at a post-synaptic site, and that SCGx induces α-adrenergic supersensitivity in the pinealocytes. © 1982. 1982 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v31_n3_p307_Ritta http://hdl.handle.net/20.500.12110/paper_03043940_v31_n3_p307_Ritta |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adrenergic supersensitivity norepinephrine pineal gland prostaglandins superior cervical ganglion α-adrenoceptors alpha adrenergic receptor noradrenalin phentolamine propranolol prostaglandin prostaglandin e2 animal experiment endocrine system in vitro study pineal body rat Adrenergic Fibers Animal Denervation Dinoprostone Dose-Response Relationship, Drug Ganglia, Sympathetic Male Norepinephrine Pineal Gland Prostaglandins E Radioimmunoassay Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Support, Non-U.S. Gov't |
| spellingShingle |
adrenergic supersensitivity norepinephrine pineal gland prostaglandins superior cervical ganglion α-adrenoceptors alpha adrenergic receptor noradrenalin phentolamine propranolol prostaglandin prostaglandin e2 animal experiment endocrine system in vitro study pineal body rat Adrenergic Fibers Animal Denervation Dinoprostone Dose-Response Relationship, Drug Ganglia, Sympathetic Male Norepinephrine Pineal Gland Prostaglandins E Radioimmunoassay Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Support, Non-U.S. Gov't Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro |
| topic_facet |
adrenergic supersensitivity norepinephrine pineal gland prostaglandins superior cervical ganglion α-adrenoceptors alpha adrenergic receptor noradrenalin phentolamine propranolol prostaglandin prostaglandin e2 animal experiment endocrine system in vitro study pineal body rat Adrenergic Fibers Animal Denervation Dinoprostone Dose-Response Relationship, Drug Ganglia, Sympathetic Male Norepinephrine Pineal Gland Prostaglandins E Radioimmunoassay Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Support, Non-U.S. Gov't |
| description |
Rat pineal glands incubated in vitro with 10 or 100 μM norepinephrine (NE) released 51% and 415% more prostaglandin E2 (PGE2) to the medium than in the absence of NE. Phentolamine (10 μM) prevented fully the effect of NE at both concentrations, whereas propranolol failed to affect it significantly. After superior cervical ganglionectomy (SCGx), NE-induced PGE2 release was significantly higher than in sham-operated controls - an effect also blocked by phentolamine but not by oropranolol. These results suggest that NE releases PGE2 in rat pineals via α-adrenoceptors, acting at a post-synaptic site, and that SCGx induces α-adrenergic supersensitivity in the pinealocytes. © 1982. |
| title |
Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro |
| title_short |
Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro |
| title_full |
Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro |
| title_fullStr |
Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro |
| title_full_unstemmed |
Involvement of α-adrenoceptors in norepinephrine-induced prostaglandin E2 release by rat pineal gland in vitro |
| title_sort |
involvement of α-adrenoceptors in norepinephrine-induced prostaglandin e2 release by rat pineal gland in vitro |
| publishDate |
1982 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043940_v31_n3_p307_Ritta http://hdl.handle.net/20.500.12110/paper_03043940_v31_n3_p307_Ritta |
| _version_ |
1768542081407516672 |