Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats

The response of female BDVI rats bearing diethylnitrosamine (DENA)-induced hepatic tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. (1) The heme pathway operates in these tumors but they were less affected by HCB than the liver. (2) Tumors did not accumulate porphyrins al...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wainstok de Calmanovici, Rosa, Cochón, Adriana Cristina, San Martín de Viale, Leonor Carmen
Publicado:	1991
Materias:	diethylnitrosamine hepatocarcinoma hexachlorobenzene porphyria porphyrins animal model article controlled study liver tumor priority journal rat 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carcinoma, Hepatocellular Cytochrome P-450 Enzyme System Diethylnitrosamine Female Ferrochelatase Hexachlorobenzene Liver Liver Neoplasms Porphobilinogen Porphyria Porphyrins Rats Support, Non-U.S. Gov't
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043835_v58_n3_p225_WainstokdeCalmanovici http://hdl.handle.net/20.500.12110/paper_03043835_v58_n3_p225_WainstokdeCalmanovici
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03043835_v58_n3_p225_WainstokdeCalmanovici
record_format	dspace
spelling	paper:paper_03043835_v58_n3_p225_WainstokdeCalmanovici2023-06-08T15:29:19Z Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats Wainstok de Calmanovici, Rosa Cochón, Adriana Cristina San Martín de Viale, Leonor Carmen diethylnitrosamine hepatocarcinoma hexachlorobenzene porphyria porphyrins diethylnitrosamine hexachlorobenzene animal model article controlled study liver tumor porphyria priority journal rat 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carcinoma, Hepatocellular Cytochrome P-450 Enzyme System Diethylnitrosamine Female Ferrochelatase Hexachlorobenzene Liver Liver Neoplasms Porphobilinogen Porphyria Porphyrins Rats Support, Non-U.S. Gov't The response of female BDVI rats bearing diethylnitrosamine (DENA)-induced hepatic tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. (1) The heme pathway operates in these tumors but they were less affected by HCB than the liver. (2) Tumors did not accumulate porphyrins although the surrounding liver accumulated more porphyrins than livers treated with HCB. (3) DENA HCB livers which developed a well defined tumor showed slightly less porphyrinogen carboxylyase inhibition and δ-aminolaevulinate synthase induction than HCB rats. (4) The results of the present work suggest that endogenously formed porphyrins would be unable to be accumulated by DENA-induced tumors when the tumoral development precedes the onset of the porphyria. © 1991. Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cochón, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martín de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1991 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043835_v58_n3_p225_WainstokdeCalmanovici http://hdl.handle.net/20.500.12110/paper_03043835_v58_n3_p225_WainstokdeCalmanovici
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	diethylnitrosamine hepatocarcinoma hexachlorobenzene porphyria porphyrins diethylnitrosamine hexachlorobenzene animal model article controlled study liver tumor porphyria priority journal rat 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carcinoma, Hepatocellular Cytochrome P-450 Enzyme System Diethylnitrosamine Female Ferrochelatase Hexachlorobenzene Liver Liver Neoplasms Porphobilinogen Porphyria Porphyrins Rats Support, Non-U.S. Gov't
spellingShingle	diethylnitrosamine hepatocarcinoma hexachlorobenzene porphyria porphyrins diethylnitrosamine hexachlorobenzene animal model article controlled study liver tumor porphyria priority journal rat 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carcinoma, Hepatocellular Cytochrome P-450 Enzyme System Diethylnitrosamine Female Ferrochelatase Hexachlorobenzene Liver Liver Neoplasms Porphobilinogen Porphyria Porphyrins Rats Support, Non-U.S. Gov't Wainstok de Calmanovici, Rosa Cochón, Adriana Cristina San Martín de Viale, Leonor Carmen Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats
topic_facet	diethylnitrosamine hepatocarcinoma hexachlorobenzene porphyria porphyrins diethylnitrosamine hexachlorobenzene animal model article controlled study liver tumor porphyria priority journal rat 5-Aminolevulinate Synthetase Aminolevulinic Acid Animal Carcinoma, Hepatocellular Cytochrome P-450 Enzyme System Diethylnitrosamine Female Ferrochelatase Hexachlorobenzene Liver Liver Neoplasms Porphobilinogen Porphyria Porphyrins Rats Support, Non-U.S. Gov't
description	The response of female BDVI rats bearing diethylnitrosamine (DENA)-induced hepatic tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. (1) The heme pathway operates in these tumors but they were less affected by HCB than the liver. (2) Tumors did not accumulate porphyrins although the surrounding liver accumulated more porphyrins than livers treated with HCB. (3) DENA HCB livers which developed a well defined tumor showed slightly less porphyrinogen carboxylyase inhibition and δ-aminolaevulinate synthase induction than HCB rats. (4) The results of the present work suggest that endogenously formed porphyrins would be unable to be accumulated by DENA-induced tumors when the tumoral development precedes the onset of the porphyria. © 1991.
author	Wainstok de Calmanovici, Rosa Cochón, Adriana Cristina San Martín de Viale, Leonor Carmen
author_facet	Wainstok de Calmanovici, Rosa Cochón, Adriana Cristina San Martín de Viale, Leonor Carmen
author_sort	Wainstok de Calmanovici, Rosa
title	Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats
title_short	Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats
title_full	Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats
title_fullStr	Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats
title_full_unstemmed	Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats
title_sort	influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats
publishDate	1991
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043835_v58_n3_p225_WainstokdeCalmanovici http://hdl.handle.net/20.500.12110/paper_03043835_v58_n3_p225_WainstokdeCalmanovici
work_keys_str_mv	AT wainstokdecalmanovicirosa influenceofhepatictumorscausedbydiethylnitrosamineonhexachlorobenzeneinducedporphyriainrats AT cochonadrianacristina influenceofhepatictumorscausedbydiethylnitrosamineonhexachlorobenzeneinducedporphyriainrats AT sanmartindevialeleonorcarmen influenceofhepatictumorscausedbydiethylnitrosamineonhexachlorobenzeneinducedporphyriainrats
_version_	1768543559976222720

Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats

Ejemplares similares