Tumor-specific MAGE proteins as regulators of p53 function
Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms cont...
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paper:paper_03043835_v325_n1_p11_Ladelfa2023-06-08T15:29:18Z Tumor-specific MAGE proteins as regulators of p53 function Ladelfa, María Fátima Monte, Martín Anticancer therapies MAGE P53 Transcriptional inhibition etoposide histone deacetylase inhibitor melanoma antigen 1 protein Bax protein p53 survivin trichostatin A carcinogenesis cell proliferation drug cytotoxicity drug targeting gene expression regulation head and neck carcinoma human melanoma multiple myeloma nonhuman priority journal protein expression protein family protein function sequence homology short survey Animals Cell Growth Processes Humans Melanoma Melanoma-Specific Antigens Tumor Suppressor Protein p53 Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions. © 2012 Elsevier Ireland Ltd. Fil:Ladelfa, M.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Monte, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043835_v325_n1_p11_Ladelfa http://hdl.handle.net/20.500.12110/paper_03043835_v325_n1_p11_Ladelfa |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Anticancer therapies MAGE P53 Transcriptional inhibition etoposide histone deacetylase inhibitor melanoma antigen 1 protein Bax protein p53 survivin trichostatin A carcinogenesis cell proliferation drug cytotoxicity drug targeting gene expression regulation head and neck carcinoma human melanoma multiple myeloma nonhuman priority journal protein expression protein family protein function sequence homology short survey Animals Cell Growth Processes Humans Melanoma Melanoma-Specific Antigens Tumor Suppressor Protein p53 |
| spellingShingle |
Anticancer therapies MAGE P53 Transcriptional inhibition etoposide histone deacetylase inhibitor melanoma antigen 1 protein Bax protein p53 survivin trichostatin A carcinogenesis cell proliferation drug cytotoxicity drug targeting gene expression regulation head and neck carcinoma human melanoma multiple myeloma nonhuman priority journal protein expression protein family protein function sequence homology short survey Animals Cell Growth Processes Humans Melanoma Melanoma-Specific Antigens Tumor Suppressor Protein p53 Ladelfa, María Fátima Monte, Martín Tumor-specific MAGE proteins as regulators of p53 function |
| topic_facet |
Anticancer therapies MAGE P53 Transcriptional inhibition etoposide histone deacetylase inhibitor melanoma antigen 1 protein Bax protein p53 survivin trichostatin A carcinogenesis cell proliferation drug cytotoxicity drug targeting gene expression regulation head and neck carcinoma human melanoma multiple myeloma nonhuman priority journal protein expression protein family protein function sequence homology short survey Animals Cell Growth Processes Humans Melanoma Melanoma-Specific Antigens Tumor Suppressor Protein p53 |
| description |
Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions. © 2012 Elsevier Ireland Ltd. |
| author |
Ladelfa, María Fátima Monte, Martín |
| author_facet |
Ladelfa, María Fátima Monte, Martín |
| author_sort |
Ladelfa, María Fátima |
| title |
Tumor-specific MAGE proteins as regulators of p53 function |
| title_short |
Tumor-specific MAGE proteins as regulators of p53 function |
| title_full |
Tumor-specific MAGE proteins as regulators of p53 function |
| title_fullStr |
Tumor-specific MAGE proteins as regulators of p53 function |
| title_full_unstemmed |
Tumor-specific MAGE proteins as regulators of p53 function |
| title_sort |
tumor-specific mage proteins as regulators of p53 function |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043835_v325_n1_p11_Ladelfa http://hdl.handle.net/20.500.12110/paper_03043835_v325_n1_p11_Ladelfa |
| work_keys_str_mv |
AT ladelfamariafatima tumorspecificmageproteinsasregulatorsofp53function AT montemartin tumorspecificmageproteinsasregulatorsofp53function |
| _version_ |
1768545600171671552 |