H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1

The aim of the present study was to evaluate cell cycle regulation by scavenging H2O2 in tumor cells. A significant arrest in the G1 phase of the cell cycle was demonstrated in CH72-T4 carcinoma cells exposed to catalase, associated with a decrease in cyclin D1 and an increase in the CDK inhibitory...

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Detalles Bibliográficos
Autores principales: Policastro, Lucía Laura, Palmieri, Mónica Alejandra, Molinari de Rey, Beatriz, Durán, Hebe Alicia
Publicado: 2011
Materias:
Cancer cells
Cell cycle
Cyclin D1
Hydrogen peroxide
P27kip1
Proliferation
catalase
cyclin D1
cyclin dependent kinase inhibitor 1B
hydrogen peroxide
reactive oxygen metabolite
scavenger
animal cell
animal experiment
animal model
animal tissue
antineoplastic activity
article
cancer inhibition
carcinoma cell
cell cycle arrest
cell cycle G1 phase
cell cycle regulation
cell cycle S phase
cell level
cell nucleus
cell proliferation
cellular distribution
controlled study
cytoplasm
female
in vitro study
in vivo study
intracellular space
mouse
nonhuman
priority journal
protein analysis
protein localization
protein modification
squamous cell carcinoma
active transport
animal
drug effect
fluorescent antibody technique
metabolism
nude mouse
sensitive to carcinogenesis mouse
tumor cell line
Western blotting
Active Transport, Cell Nucleus
Animals
Blotting, Western
Catalase
Cell Line, Tumor
Cell Nucleus
Cyclin-Dependent Kinase Inhibitor p27
Female
Fluorescent Antibody Technique
Free Radical Scavengers
G1 Phase
Hydrogen Peroxide
Mice
Mice, Inbred SENCAR
Mice, Nude
Reactive Oxygen Species
S Phase
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03043835_v305_n1_p58_Ibanez
http://hdl.handle.net/20.500.12110/paper_03043835_v305_n1_p58_Ibanez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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