Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes

Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well as the role of forkhead box...

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Publicado:	2019
Materias:	Connexin43 Diabetes FOXO1 Heart Intrauterine programming Matrix metalloproteinases collagen connexin 43 messenger RNA streptozocin transcription factor FKHR adult animal experiment animal model animal tissue Article cardiomyopathy cardiovascular parameters controlled study Ctgf gene enzyme activation extracellular matrix female gene gene targeting heart hyperglycemia hypertriglyceridemia insulinemia male maternal diabetes mellitus Mmp 2 gene nonhuman pathogenesis priority journal progeny protein function rat
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v479_n_p78_Musikant http://hdl.handle.net/20.500.12110/paper_03037207_v479_n_p78_Musikant
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03037207_v479_n_p78_Musikant
record_format	dspace
spelling	paper:paper_03037207_v479_n_p78_Musikant2023-06-08T15:29:13Z Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes Connexin43 Diabetes FOXO1 Heart Intrauterine programming Matrix metalloproteinases collagen connexin 43 messenger RNA streptozocin transcription factor FKHR adult animal experiment animal model animal tissue Article cardiomyopathy cardiovascular parameters controlled study Ctgf gene enzyme activation extracellular matrix female gene gene targeting heart hyperglycemia hypertriglyceridemia insulinemia male maternal diabetes mellitus Mmp 2 gene nonhuman pathogenesis priority journal progeny protein function rat Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well as the role of forkhead box transcription factor 1 (FOXO1) in the induction of these alterations. The heart from adult offspring from control and streptozotocin-induced diabetic rats was evaluated. Increased glycemia, triglyceridemia and insulinemia and markers of cardiomyopathy were found in the offspring from diabetic rats. In the heart, an increase in active FOXO1 and mRNA levels of its target genes, Mmp-2 and Ctgf, genes related to an altered extracellular matrix remodeling, together with an increase in collagen deposition and a decrease in the connexin43 levels, were found in the offspring from diabetic rats. Altogether, these results suggest an important role of FOXO1 activation in the cardiac alterations induced by intrauterine programming in maternal diabetes. © 2018 2019 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v479_n_p78_Musikant http://hdl.handle.net/20.500.12110/paper_03037207_v479_n_p78_Musikant
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Connexin43 Diabetes FOXO1 Heart Intrauterine programming Matrix metalloproteinases collagen connexin 43 messenger RNA streptozocin transcription factor FKHR adult animal experiment animal model animal tissue Article cardiomyopathy cardiovascular parameters controlled study Ctgf gene enzyme activation extracellular matrix female gene gene targeting heart hyperglycemia hypertriglyceridemia insulinemia male maternal diabetes mellitus Mmp 2 gene nonhuman pathogenesis priority journal progeny protein function rat
spellingShingle	Connexin43 Diabetes FOXO1 Heart Intrauterine programming Matrix metalloproteinases collagen connexin 43 messenger RNA streptozocin transcription factor FKHR adult animal experiment animal model animal tissue Article cardiomyopathy cardiovascular parameters controlled study Ctgf gene enzyme activation extracellular matrix female gene gene targeting heart hyperglycemia hypertriglyceridemia insulinemia male maternal diabetes mellitus Mmp 2 gene nonhuman pathogenesis priority journal progeny protein function rat Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes
topic_facet	Connexin43 Diabetes FOXO1 Heart Intrauterine programming Matrix metalloproteinases collagen connexin 43 messenger RNA streptozocin transcription factor FKHR adult animal experiment animal model animal tissue Article cardiomyopathy cardiovascular parameters controlled study Ctgf gene enzyme activation extracellular matrix female gene gene targeting heart hyperglycemia hypertriglyceridemia insulinemia male maternal diabetes mellitus Mmp 2 gene nonhuman pathogenesis priority journal progeny protein function rat
description	Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well as the role of forkhead box transcription factor 1 (FOXO1) in the induction of these alterations. The heart from adult offspring from control and streptozotocin-induced diabetic rats was evaluated. Increased glycemia, triglyceridemia and insulinemia and markers of cardiomyopathy were found in the offspring from diabetic rats. In the heart, an increase in active FOXO1 and mRNA levels of its target genes, Mmp-2 and Ctgf, genes related to an altered extracellular matrix remodeling, together with an increase in collagen deposition and a decrease in the connexin43 levels, were found in the offspring from diabetic rats. Altogether, these results suggest an important role of FOXO1 activation in the cardiac alterations induced by intrauterine programming in maternal diabetes. © 2018
title	Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes
title_short	Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes
title_full	Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes
title_fullStr	Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes
title_full_unstemmed	Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes
title_sort	altered foxo1 activation in the programming of cardiovascular alterations by maternal diabetes
publishDate	2019
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v479_n_p78_Musikant http://hdl.handle.net/20.500.12110/paper_03037207_v479_n_p78_Musikant
_version_	1768545599991316480

Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes

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