Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS)
Ovarian hyperstimulation syndrome (OHSS) is a disorder associated with ovarian stimulation. OHSS features are ovarian enlargement with fluid shifting to the third space. Disturbances in the vasculature are considered the main changes that lead to OHSS. Our aim was to analyze the levels of angiopoiet...
Guardado en:
| Publicado: |
2013
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v365_n2_p223_Scotti http://hdl.handle.net/20.500.12110/paper_03037207_v365_n2_p223_Scotti |
| Aporte de: |
| id |
paper:paper_03037207_v365_n2_p223_Scotti |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_03037207_v365_n2_p223_Scotti2023-06-08T15:29:09Z Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS) Angiogenesis Angiopoietins OHSS Ovary angiopoietin 1 angiopoietin 2 angiopoietin receptor chorionic gonadotropin neutralizing antibody platelet derived growth factor B platelet derived growth factor beta receptor platelet derived growth factor D adult animal experiment animal tissue article cell migration controlled study endothelium cell female granulosa cell human human cell luteal cell major clinical study nonhuman ovary follicle fluid ovary hyperstimulation priority journal protein function rat risk factor Adult Angiopoietin-1 Angiopoietin-2 Animals Antibodies Case-Control Studies Cell Movement Cells, Cultured Female Follicular Fluid Humans Luteal Cells Ovarian Hyperstimulation Syndrome Ovary Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor beta Receptor, TIE-2 Ovarian hyperstimulation syndrome (OHSS) is a disorder associated with ovarian stimulation. OHSS features are ovarian enlargement with fluid shifting to the third space. Disturbances in the vasculature are considered the main changes that lead to OHSS. Our aim was to analyze the levels of angiopoietins 1 and 2 (ANGPT1 and 2) and their soluble and membrane receptors (s/mTie-2) in follicular fluid (FF) and in granulosa-lutein cells culture (GLCs) from women at risk of developing OHSS. We also evaluated the effect of ANGPT1 on endothelial cell migration. In ovaries from an OHSS rat model, we analyzed the protein concentration of ANGPTs, their mTie-2 receptor, and platelet-derived growth factor PDGF-B, -D and PDGFR-β. ANGPT1 levels were increased in both FF and GLCs from women at risk of OHSS. Incubation of these FF with an ANGPT1 neutralizing antibody decreased endothelial cell migration. In the ovaries of OHSS rat model, mTie-2 protein levels increased and PDGF-B and -D decreased. In summary, these results suggest that ANGPT1 could be another mediator in the development of OHSS. © 2012 Elsevier Ireland Ltd. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v365_n2_p223_Scotti http://hdl.handle.net/20.500.12110/paper_03037207_v365_n2_p223_Scotti |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiogenesis Angiopoietins OHSS Ovary angiopoietin 1 angiopoietin 2 angiopoietin receptor chorionic gonadotropin neutralizing antibody platelet derived growth factor B platelet derived growth factor beta receptor platelet derived growth factor D adult animal experiment animal tissue article cell migration controlled study endothelium cell female granulosa cell human human cell luteal cell major clinical study nonhuman ovary follicle fluid ovary hyperstimulation priority journal protein function rat risk factor Adult Angiopoietin-1 Angiopoietin-2 Animals Antibodies Case-Control Studies Cell Movement Cells, Cultured Female Follicular Fluid Humans Luteal Cells Ovarian Hyperstimulation Syndrome Ovary Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor beta Receptor, TIE-2 |
| spellingShingle |
Angiogenesis Angiopoietins OHSS Ovary angiopoietin 1 angiopoietin 2 angiopoietin receptor chorionic gonadotropin neutralizing antibody platelet derived growth factor B platelet derived growth factor beta receptor platelet derived growth factor D adult animal experiment animal tissue article cell migration controlled study endothelium cell female granulosa cell human human cell luteal cell major clinical study nonhuman ovary follicle fluid ovary hyperstimulation priority journal protein function rat risk factor Adult Angiopoietin-1 Angiopoietin-2 Animals Antibodies Case-Control Studies Cell Movement Cells, Cultured Female Follicular Fluid Humans Luteal Cells Ovarian Hyperstimulation Syndrome Ovary Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor beta Receptor, TIE-2 Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS) |
| topic_facet |
Angiogenesis Angiopoietins OHSS Ovary angiopoietin 1 angiopoietin 2 angiopoietin receptor chorionic gonadotropin neutralizing antibody platelet derived growth factor B platelet derived growth factor beta receptor platelet derived growth factor D adult animal experiment animal tissue article cell migration controlled study endothelium cell female granulosa cell human human cell luteal cell major clinical study nonhuman ovary follicle fluid ovary hyperstimulation priority journal protein function rat risk factor Adult Angiopoietin-1 Angiopoietin-2 Animals Antibodies Case-Control Studies Cell Movement Cells, Cultured Female Follicular Fluid Humans Luteal Cells Ovarian Hyperstimulation Syndrome Ovary Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor beta Receptor, TIE-2 |
| description |
Ovarian hyperstimulation syndrome (OHSS) is a disorder associated with ovarian stimulation. OHSS features are ovarian enlargement with fluid shifting to the third space. Disturbances in the vasculature are considered the main changes that lead to OHSS. Our aim was to analyze the levels of angiopoietins 1 and 2 (ANGPT1 and 2) and their soluble and membrane receptors (s/mTie-2) in follicular fluid (FF) and in granulosa-lutein cells culture (GLCs) from women at risk of developing OHSS. We also evaluated the effect of ANGPT1 on endothelial cell migration. In ovaries from an OHSS rat model, we analyzed the protein concentration of ANGPTs, their mTie-2 receptor, and platelet-derived growth factor PDGF-B, -D and PDGFR-β. ANGPT1 levels were increased in both FF and GLCs from women at risk of OHSS. Incubation of these FF with an ANGPT1 neutralizing antibody decreased endothelial cell migration. In the ovaries of OHSS rat model, mTie-2 protein levels increased and PDGF-B and -D decreased. In summary, these results suggest that ANGPT1 could be another mediator in the development of OHSS. © 2012 Elsevier Ireland Ltd. |
| title |
Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS) |
| title_short |
Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS) |
| title_full |
Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS) |
| title_fullStr |
Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS) |
| title_full_unstemmed |
Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS) |
| title_sort |
involvement of the angpts/tie-2 system in ovarian hyperstimulation syndrome (ohss) |
| publishDate |
2013 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v365_n2_p223_Scotti http://hdl.handle.net/20.500.12110/paper_03037207_v365_n2_p223_Scotti |
| _version_ |
1768542789680758784 |