Genetically modified mouse models in studies of luteinising hormone action
Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-α(Cα), luteinising hormone (LH)...
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2006
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v252_n1-2_p126_Huhtaniemi http://hdl.handle.net/20.500.12110/paper_03037207_v252_n1-2_p126_Huhtaniemi |
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paper:paper_03037207_v252_n1-2_p126_Huhtaniemi2023-06-08T15:29:05Z Genetically modified mouse models in studies of luteinising hormone action Choriongonadotrophin (hCG) Knockout mice LH receptor Luteinising hormone (LH) Pituitary-gonadal function Reproduction Sexual development Transgenic mice chorionic gonadotropin luteinizing hormone luteinizing hormone receptor DNA modification gene overexpression hormone action hypophysis function knockout mouse Leydig cell maturation nonhuman oocyte phenotype priority journal reproduction reverse transcription polymerase chain reaction review sexual development spermatogenesis transgenic mouse Animals Animals, Genetically Modified Female Luteinizing Hormone Male Mice Mice, Knockout Mice, Transgenic Ovary Receptors, LH Testis Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-α(Cα), luteinising hormone (LH) β and follicle-stimulating hormone (FSH) β subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+). © 2006 Elsevier Ireland Ltd. All rights reserved. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v252_n1-2_p126_Huhtaniemi http://hdl.handle.net/20.500.12110/paper_03037207_v252_n1-2_p126_Huhtaniemi |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Choriongonadotrophin (hCG) Knockout mice LH receptor Luteinising hormone (LH) Pituitary-gonadal function Reproduction Sexual development Transgenic mice chorionic gonadotropin luteinizing hormone luteinizing hormone receptor DNA modification gene overexpression hormone action hypophysis function knockout mouse Leydig cell maturation nonhuman oocyte phenotype priority journal reproduction reverse transcription polymerase chain reaction review sexual development spermatogenesis transgenic mouse Animals Animals, Genetically Modified Female Luteinizing Hormone Male Mice Mice, Knockout Mice, Transgenic Ovary Receptors, LH Testis |
| spellingShingle |
Choriongonadotrophin (hCG) Knockout mice LH receptor Luteinising hormone (LH) Pituitary-gonadal function Reproduction Sexual development Transgenic mice chorionic gonadotropin luteinizing hormone luteinizing hormone receptor DNA modification gene overexpression hormone action hypophysis function knockout mouse Leydig cell maturation nonhuman oocyte phenotype priority journal reproduction reverse transcription polymerase chain reaction review sexual development spermatogenesis transgenic mouse Animals Animals, Genetically Modified Female Luteinizing Hormone Male Mice Mice, Knockout Mice, Transgenic Ovary Receptors, LH Testis Genetically modified mouse models in studies of luteinising hormone action |
| topic_facet |
Choriongonadotrophin (hCG) Knockout mice LH receptor Luteinising hormone (LH) Pituitary-gonadal function Reproduction Sexual development Transgenic mice chorionic gonadotropin luteinizing hormone luteinizing hormone receptor DNA modification gene overexpression hormone action hypophysis function knockout mouse Leydig cell maturation nonhuman oocyte phenotype priority journal reproduction reverse transcription polymerase chain reaction review sexual development spermatogenesis transgenic mouse Animals Animals, Genetically Modified Female Luteinizing Hormone Male Mice Mice, Knockout Mice, Transgenic Ovary Receptors, LH Testis |
| description |
Numerous genetically modified mouse models have recently been developed for the study of the pituitary-gonadal interactions. They include spontaneous or engineered knockouts (KO) of the gonadotrophin-releasing hormone (GnRH) and its receptor, the gonadotrophin common-α(Cα), luteinising hormone (LH) β and follicle-stimulating hormone (FSH) β subunits, and the two gonadotrophin receptors (R), LHR and FSHR. In addition, there are also transgenic (TG) mice overexpressing gonadotrophin subunits and producing supraphysiological levels of these hormones. These models have offered relevant phenocopies for similar mutations in humans and to a great extent expanded our knowledge on normal and pathological functions of the hypothalamic-pituitary-gonadal (HPG) axis. The purpose of this article is to review some of our recent findings on two such mouse models, the LHR KO mouse (LuRKO), and the hCG overexpressing TG mouse (hCG+). © 2006 Elsevier Ireland Ltd. All rights reserved. |
| title |
Genetically modified mouse models in studies of luteinising hormone action |
| title_short |
Genetically modified mouse models in studies of luteinising hormone action |
| title_full |
Genetically modified mouse models in studies of luteinising hormone action |
| title_fullStr |
Genetically modified mouse models in studies of luteinising hormone action |
| title_full_unstemmed |
Genetically modified mouse models in studies of luteinising hormone action |
| title_sort |
genetically modified mouse models in studies of luteinising hormone action |
| publishDate |
2006 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03037207_v252_n1-2_p126_Huhtaniemi http://hdl.handle.net/20.500.12110/paper_03037207_v252_n1-2_p126_Huhtaniemi |
| _version_ |
1768542363451392000 |