Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder
Objectives: To assess brain functional connectivity and variability in adults with attention deficit/hyperactivity disorder (ADHD) or euthymic bipolar disorder (BD) relative to a control (CT) group. Methods: Electroencephalography (EEG) was measured in 35 participants (BD = 11; ADHD = 9; CT = 15) du...
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2014
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paper:paper_0302282X_v69_n2_p65_Barttfeld2023-06-08T15:28:09Z Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder Attention deficit/hyperactivity disorder Bipolar disorder Electroencephalography Functional connectivity Intrinsic variability adult amnesia anxiety article attention deficit disorder bipolar disorder brain function brain functional connectivity brain variability clinical article clinical assessment clinical evaluation controlled study depression disease association educational status electroencephalography executive function female frontal lobe human hyperactivity impulsiveness male neuropsychological test priority journal attention deficit disorder bipolar disorder brain cognitive defect middle aged multivariate analysis nerve tract pathophysiology physiology psychology rest time Article comparative study electroencephalogram functional connectivity functional magnetic resonance imaging neurologic examination temporal variability Adult Anxiety Attention Deficit Disorder with Hyperactivity Bipolar Disorder Brain Cognition Disorders Depression Electroencephalography Humans Impulsive Behavior Male Middle Aged Multivariate Analysis Neural Pathways Neuropsychological Tests Rest Time Factors Objectives: To assess brain functional connectivity and variability in adults with attention deficit/hyperactivity disorder (ADHD) or euthymic bipolar disorder (BD) relative to a control (CT) group. Methods: Electroencephalography (EEG) was measured in 35 participants (BD = 11; ADHD = 9; CT = 15) during an eyes-closed 10-min rest period, and connectivity and graph theory metrics were computed. A coefficient of variation (CV) computed also the connectivity's temporal variability of EEG. Multivariate associations between functional connectivity and clinical and neuropsychological profiles were evaluated. Results: An enhancement of functional connectivity was observed in the ADHD (fronto-occipital connections) and BD (diffuse connections) groups. However, compared with CTs, intrinsic variability (CV) was enhanced in the ADHD group and reduced in the BD group. Graph theory metrics confirmed the existence of several abnormal network features in both affected groups. Significant associations of connectivity with symptoms were also observed. In the ADHD group, temporal variability of functional connections was associated with executive function and memory deficits. Depression, hyperactivity and impulsivity levels in the ADHD group were associated with abnormal intrinsic connectivity. In the BD group, levels of anxiety and depression were related to abnormal frontotemporal connectivity. Conclusions: In the ADHD group, we found that intrinsic variability was associated with deficits in cognitive performance and that connectivity abnormalities were related to ADHD symptomatology. The BD group exhibited less intrinsic variability and more diffuse long-range brain connections, and those abnormalities were related to interindividual differences in depression and anxiety. These preliminary results are relevant for neurocognitive models of abnormal brain connectivity in both disorders. © 2014 S. Karger AG, Basel. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0302282X_v69_n2_p65_Barttfeld http://hdl.handle.net/20.500.12110/paper_0302282X_v69_n2_p65_Barttfeld |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Attention deficit/hyperactivity disorder Bipolar disorder Electroencephalography Functional connectivity Intrinsic variability adult amnesia anxiety article attention deficit disorder bipolar disorder brain function brain functional connectivity brain variability clinical article clinical assessment clinical evaluation controlled study depression disease association educational status electroencephalography executive function female frontal lobe human hyperactivity impulsiveness male neuropsychological test priority journal attention deficit disorder bipolar disorder brain cognitive defect middle aged multivariate analysis nerve tract pathophysiology physiology psychology rest time Article comparative study electroencephalogram functional connectivity functional magnetic resonance imaging neurologic examination temporal variability Adult Anxiety Attention Deficit Disorder with Hyperactivity Bipolar Disorder Brain Cognition Disorders Depression Electroencephalography Humans Impulsive Behavior Male Middle Aged Multivariate Analysis Neural Pathways Neuropsychological Tests Rest Time Factors |
| spellingShingle |
Attention deficit/hyperactivity disorder Bipolar disorder Electroencephalography Functional connectivity Intrinsic variability adult amnesia anxiety article attention deficit disorder bipolar disorder brain function brain functional connectivity brain variability clinical article clinical assessment clinical evaluation controlled study depression disease association educational status electroencephalography executive function female frontal lobe human hyperactivity impulsiveness male neuropsychological test priority journal attention deficit disorder bipolar disorder brain cognitive defect middle aged multivariate analysis nerve tract pathophysiology physiology psychology rest time Article comparative study electroencephalogram functional connectivity functional magnetic resonance imaging neurologic examination temporal variability Adult Anxiety Attention Deficit Disorder with Hyperactivity Bipolar Disorder Brain Cognition Disorders Depression Electroencephalography Humans Impulsive Behavior Male Middle Aged Multivariate Analysis Neural Pathways Neuropsychological Tests Rest Time Factors Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder |
| topic_facet |
Attention deficit/hyperactivity disorder Bipolar disorder Electroencephalography Functional connectivity Intrinsic variability adult amnesia anxiety article attention deficit disorder bipolar disorder brain function brain functional connectivity brain variability clinical article clinical assessment clinical evaluation controlled study depression disease association educational status electroencephalography executive function female frontal lobe human hyperactivity impulsiveness male neuropsychological test priority journal attention deficit disorder bipolar disorder brain cognitive defect middle aged multivariate analysis nerve tract pathophysiology physiology psychology rest time Article comparative study electroencephalogram functional connectivity functional magnetic resonance imaging neurologic examination temporal variability Adult Anxiety Attention Deficit Disorder with Hyperactivity Bipolar Disorder Brain Cognition Disorders Depression Electroencephalography Humans Impulsive Behavior Male Middle Aged Multivariate Analysis Neural Pathways Neuropsychological Tests Rest Time Factors |
| description |
Objectives: To assess brain functional connectivity and variability in adults with attention deficit/hyperactivity disorder (ADHD) or euthymic bipolar disorder (BD) relative to a control (CT) group. Methods: Electroencephalography (EEG) was measured in 35 participants (BD = 11; ADHD = 9; CT = 15) during an eyes-closed 10-min rest period, and connectivity and graph theory metrics were computed. A coefficient of variation (CV) computed also the connectivity's temporal variability of EEG. Multivariate associations between functional connectivity and clinical and neuropsychological profiles were evaluated. Results: An enhancement of functional connectivity was observed in the ADHD (fronto-occipital connections) and BD (diffuse connections) groups. However, compared with CTs, intrinsic variability (CV) was enhanced in the ADHD group and reduced in the BD group. Graph theory metrics confirmed the existence of several abnormal network features in both affected groups. Significant associations of connectivity with symptoms were also observed. In the ADHD group, temporal variability of functional connections was associated with executive function and memory deficits. Depression, hyperactivity and impulsivity levels in the ADHD group were associated with abnormal intrinsic connectivity. In the BD group, levels of anxiety and depression were related to abnormal frontotemporal connectivity. Conclusions: In the ADHD group, we found that intrinsic variability was associated with deficits in cognitive performance and that connectivity abnormalities were related to ADHD symptomatology. The BD group exhibited less intrinsic variability and more diffuse long-range brain connections, and those abnormalities were related to interindividual differences in depression and anxiety. These preliminary results are relevant for neurocognitive models of abnormal brain connectivity in both disorders. © 2014 S. Karger AG, Basel. |
| title |
Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder |
| title_short |
Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder |
| title_full |
Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder |
| title_fullStr |
Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder |
| title_full_unstemmed |
Functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder |
| title_sort |
functional connectivity and temporal variability of brain connections in adults with attention deficit/hyperactivity disorder and bipolar disorder |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0302282X_v69_n2_p65_Barttfeld http://hdl.handle.net/20.500.12110/paper_0302282X_v69_n2_p65_Barttfeld |
| _version_ |
1768543799623024640 |